Controlled release of doxorubicin from polyethylene glycol functionalized melanin nanoparticles for breast cancer therapy: Part I. Production and drug release performance of the melanin nanoparticles

Ozlu, Busra; Kabay, Gözde; Bocek, Ilyas; Yılmaz, Merve; Pişkin, A. Kevser; Shim, Bong Sup; Mutlu, Mehmet

doi:10.1016/j.ijpharm.2019.118613

Cited by 29 publications

(20 citation statements)

References 19 publications

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“…The characteristic peak at 490 nm for Doxo was observed in the UV-Vis spectra, indicating the successful loading of Doxo onto PheoA-MNPs ( Figure 2 B). The maximum drug loading capacity was found to be 35% (Doxo:MNPs, w:w), consistent with that found in the previously reported literature [ 20 , 21 , 22 , 23 ]. For instance, Du et al developed polydopamine nanoparticles conjugated with 33 wt% of Doxo to be used as nanotheranostics for multimodal imaging-guided cancer therapy [ 20 , 24 ].…”

Section: Resultssupporting

confidence: 90%

“…It was previously shown that melanin-like nanoparticles have the ability to bind to drugs with aromatic structures via hydrogen bonding or π-π stacking [ 21 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. In this study, it was also shown that chemotherapeutic drugs with tetra- and pentacyclic rings, can be successfully loaded onto the surface of MNPs.…”

Section: Resultsmentioning

confidence: 99%

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T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

et al. 2020

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In this study, we designed near-infrared (NIR)-responsive Mn2+-doped melanin-like poly(L-DOPA) nanoparticles (MNPs), which act as multifunctional nano-platforms for cancer therapy. MNPs, exhibited favorable π-π stacking, drug loading, dual stimuli (NIR and glutathione) responsive drug release, photothermal and photodynamic therapeutic activities, and T1-positive contrast for magnetic resonance imaging (MRI). First, MNPs were fabricated via KMnO4 oxidation, where the embedded Mn2+ acted as a T1-weighted contrast agent. MNPs were then modified using a photosensitizer, Pheophorbide A, via a reducible disulfide linker for glutathione-responsive intracellular release, and then loaded with doxorubicin through π-π stacking and hydrogen bonding. The therapeutic potential of MNPs was further explored via targeted design. MNPs were conjugated with folic acid (FA) and loaded with SN38, thereby demonstrating their ability to bind to different anti-cancer drugs and their potential as a versatile platform, integrating targeted cancer therapy and MRI-guided photothermal and chemotherapeutic therapy. The multimodal therapeutic functions of MNPs were investigated in terms of T1-MR contrast phantom study, photothermal and photodynamic activity, stimuli-responsive drug release, enhanced cellular uptake, and in vivo tumor ablation studies.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

et al. 2020

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“…Further studies on HMPDA was carried out by Tran et al who showed that silica cores could be simply removed in water and, in particular, that the time needed for the removal is dependent on temperature and duration of the PDA coating process [150]. Similarly, Ozlu et al developed polyethylene glycol (PEG) conjugated PDA for DOX delivery, demonstrating that PEG covalent surface modification led to an increased stability in blood circulation, and to a dramatic reduction on NP dimensions (15 ± 2.2 nm) in comparison with other studies [151]. DOX delivery resulted to be diffusion controlled.…”

Section: Mnp For the Delivery Of Anti-cancer Drugsmentioning

confidence: 97%

“…Most recent research is focused on the development of nanocarriers which can effectively deliver the therapeutic agents on the target site, without early leakage, and consequently release upon a specific stimuli, such as NIR irradiation also in combination with pH [41]. This behavior can be achieved by simple or modified MNP [151,185]. Combining drug binding capacity of MNP with their innate PTT efficacy, Zhang et al developed an outstanding synergistic PTT-CT cancer treatment [186].…”

Section: Ptt-chemotherapymentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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“…Therefore, more doses of the drug are needed to maintain plasma balance, causing discomfort to the patient. Scientists are working hard to develop novel drug delivery systems in order to provide appropriate drug concentrations to meet therapeutic needs [163]. The ideal drug release is rapid, at a constant rate, and sustained so that the drug be immediately effective while achieving a long effect [164].…”

Section: Controlled Drug Deliverymentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

514

260

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Controlled release of doxorubicin from polyethylene glycol functionalized melanin nanoparticles for breast cancer therapy: Part I. Production and drug release performance of the melanin nanoparticles

Cited by 29 publications

References 19 publications

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Chitosan Derivatives and Their Application in Biomedicine

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