Controlled release of doxorubicin from amphiphilic depsipeptide–PDO–PEG-based copolymer nanosized microspheres

Zhang, Li; Feng, Yakai; Tian, Hong; Shi, Changcan; Zhao, Miao; Guo, Jintang

doi:10.1016/j.reactfunctpolym.2013.06.012

Cited by 15 publications

(11 citation statements)

References 56 publications

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“…We selected hydrophobic copolymers from a depsipeptide and dilactide to covalently link low molecular weight PEIs as depsipeptide based copolymers are biodegradable with benefi cial biocompatibility during degradation. [48][49][50][51][52] Our strategy consists of the synthesis of biodegradable block copolymers based on PEI (1 800 g mol −1 ) and poly[(L-lactide)-co -(3( S )-methyl-2,5-morpholinedione)] (P(LA-co -MMD)) blocks, and the formation of nanoparticles thereof by self-assembly. [53][54][55] In our previous study, we have prepared microparticles from mPEG-b-P(MMD-co-GA)-g-PEI.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Shi

Zhang

et al. 2015

Adv Healthcare Materials

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Amphiphilic block copolymers containing biodegradable hydrophobic segments of depsipeptide based copolymers have been synthesized and explored as gene carriers for enhancing proliferation of endothelial cells in vitro. These polymers form nanoparticles (NPs) with positive charges on their surface, which could condense recombinant plasmids of enhanced green fluorescent protein plasmid and ZNF580 gene (pEGFP-ZNF580) and protect them against DNase I. ZNF580 gene is efficiently transported into EA.hy926 cells to promote their proliferation, whereby the transfection efficiency of NPs/pEGFP-ZNF580 is approximately similar to that of Lipofectamine 2000. These results indicate that the NPs might have potential as a carrier for pEGFP-ZNF580, which could support endothelialization of cardiovascular implants.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Shi

Zhang

et al. 2015

Adv Healthcare Materials

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“…The modified electrospray method employed here allows for comparable or increased encapsulation of PDO (>70%) and PLGA (>80%), respectively, where traditional emulsion methods exhibit encapsulation efficiencies of 60–80% for PLGA . With respect to PDO, due to the material's relative insolubility, alternative methods for the fabrication of sustained delivery devices have been employed to include melt extrusion and thin film fabrication along with traditional emulsion techniques exhibiting encapsulation efficiencies of 26–62% for pure and copolymeric systems . In addition, release profiles of synthesized PDO/PLGA nanospheres (Figure ) revealed a minimized burst release within the first 8 h of incubation for both nanospheres and steady release to 18 days (PDO) and 6 days (PLGA), respectively.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic biphasic 3‐D nanocomposite scaffold for osteochondral regeneration

2013

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Scaffold-based interfacial tissue engineering aims to not only provide the structural and mechanical framework for cellular growth and tissue regeneration, but also direct cell behavior. Due to the disparity in composition of the osteochondral (cartilage and bone) interface, this work has developed a novel biomimetic biphasic nanocomposite scaffold integrating two biocompatible polymers containing tissue-specific growth factor-encapsulated core-shell nanospheres. Specifically, a poly(caprolactone) (PCL)-based bone layer was successfully integrated with a poly(ethylene glycol) (PEG) hydrogel cartilage layer. In addition, a novel nanosphere fabrication technique for efficient growth factor encapsulation and sustained delivery via a wet coaxial electrospray technique was developed. Human bone marrow mesenchymal stem cell (hMSC) adhesion, osteogenic, and chondrogenic differentiation were evaluated. Our in vitro results showed significantly improved hMSC adhesion and differentiation in bone and cartilage layers, respectively. Studies have demonstrated promising results with novel biphasic nanocomposite scaffold for osteochondral tissue regeneration, thus, warranting further studies.

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“…Meanwhile, the copolymers synthesized from MMD shows different crystallization degrees owing to the optical activity of the monomer [35,40,41]. Moreover, the degradation products of MMD including L-amino acids can stimulate the proliferation of endothelial cells via a signal pathway and be properly metabolized by living tissues [42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, polydepsipeptides have been widely accepted as a valuable class of synthetic biodegradable polymers because the strong intermolecular hydrogen-bond interaction between the amide groups can achieve a higher reactivity in ring-opening polymerization (ROP), and the presence of easily hydrolysable ester linkages and amide-bonds can ensure high degradability [ 32 , 33 , 34 , 35 ]. In 1985, Helder et al synthesized polydepsipeptides by ROP of morpholine-2,5-dione derivatives for the first time [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, 3( S )-methyl-morpholine-2,5-dione (MMD), which possesses a better performance of polymerization than other morpholine-2,5-dione derivatives with large substitutes, has been a promising derivative to develop biodegradable drug delivery systems [ 35 ]. Meanwhile, the copolymers synthesized from MMD shows different crystallization degrees owing to the optical activity of the monomer [ 35 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

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Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) Nanofibrous Scaffolds for Tissue Engineering

et al. 2016

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Biomimetic scaffolds have been investigated in vascular tissue engineering for many years. Excellent biodegradable materials are desired as temporary scaffolds to support cell growth and disappear gradually with the progress of guided tissue regeneration. In the present paper, a series of biodegradable copolymers were synthesized and used to prepared micro/nanofibrous scaffolds for vascular tissue engineering. Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) [P(LA-co-GA-co-MMD)] copolymers with different L-lactide (LA), glycolide (GA), and 3(S)-methyl-2,5-morpholinedione (MMD) contents were synthesized using stannous octoate as a catalyst. Moreover, the P(LA-co-GA-co-MMD) nanofibrous scaffolds were prepared by electrospinning technology. The morphology of scaffolds was analyzed by scanning electron microscopy (SEM), and the results showed that the fibers are smooth, regular, and randomly oriented with diameters of 700˘100 nm. The weight loss of scaffolds increased significantly with the increasing content of MMD, indicating good biodegradable property of the scaffolds. In addition, the cytocompatibility of electrospun nanofibrous scaffolds was tested by human umbilical vein endothelial cells. It is demonstrated that the cells could attach and proliferate well on P(LA-co-GA-co-MMD) scaffolds and, consequently, form a cell monolayer fully covering on the scaffold surface. Furthermore, the P(LA-co-GA-co-MMD) scaffolds benefit to excellent cell infiltration after subcutaneous implantation. These results indicated that the P(LA-co-GA-co-MMD) nanofibrous scaffolds could be potential candidates for vascular tissue engineering.

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Controlled release of doxorubicin from amphiphilic depsipeptide–PDO–PEG-based copolymer nanosized microspheres

Cited by 15 publications

References 56 publications

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Biomimetic biphasic 3‐D nanocomposite scaffold for osteochondral regeneration

Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) Nanofibrous Scaffolds for Tissue Engineering

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