Controlled Release of Dexamethasone from Microcapsules Produced by Polyelectrolyte Layer-by-Layer Nanoassembly

Pargaonkar, Nikhil; Lvov, Yuri; Li, Ning; Steenekamp, Jan; Villiers, Melgardt M. de

doi:10.1007/s11095-005-2600-0

Cited by 100 publications

(84 citation statements)

References 25 publications

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“…Ocular delivery [ 193 ] Drug crystals Poly(allylamine hydrochloride), protamine sulfate and BSA Solid Curcumin LbL coating led to high surface potential and stabilization of drug nanocolloids. Polyelectrolyte LBL encapsulation allowed sustained release of poorly water soluble drug for 10-20 h…”

Section: Controlled Drug Deliverymentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Controlled Drug Deliverymentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…2,3 The spontaneous sequential adsorption of dissolved cationic and anionic polyelectrolytes on the substrate leads to the formation of ordered multilayer assemblies on the solid substrate surface. 4 These multilayers are widely used in biotechnology as controlled release systems, cell growth surfaces, anti-adhesive coatings and stimuli responsive surfaces. As the system is composed of charged molecules, it is ideal to control the release of charged bioactive agents such as cytokines and the strength of electrostatic interactions between the film and the cytokine should be a key parameter to determine the rate of release.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings

et al. 2016

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(2016) Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings. Biomacromolecules, 17 (6). pp. 2189 -2198 . ISSN 1525 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/34683/1/Knopf-Marques%20et%20al%202016%20Revised %20final.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. . Moreover, we demonstrate that crosslinking PLL/HA film using HA-aldehyde is already effective by itself to limit inflammatory processes.Finally, this functionalized self-crosslinked PLL/HA-aldehyde films constitutes an innovative and efficient candidate for immunomodulation of any kind of implants of various architecture and properties.

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“…The first approach directly used proteins, for instance, as the depositing species to prepare bioactive core-shell particles [17][18][19]. The second approach involved direct coverage of drug microcrystals, such as ibuprofen (IBU) [20,21], furosemide [22], vitamin K 3 [23], insulin [23], dexamethasone [24,25], and indomethacin [26][27][28] with polyelectrolyte multilayer films for prolonged release. The third approach demonstrated fabricating hollow microcapsules with polyelectrolyte multilayer walls by removing the template cores and loading drugs, enzymes, and proteins into the capsules for delivery [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Microcapsules for controlled release fabricated via layer-by-layer self-assembly of polyelectrolytes

Wang

Sun

et al. 2008

Journal of Experimental Nanoscience

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Layer-by-layer (LbL) self-assembly of oppositely charged polyelectrolytes on different templates by alternating deposition is a versatile method enabling the construction of ultrathin multilayer films with tunable thickness, composition, and functions. The principal driving force for the LbL self-assembly is dominantly the electrostatic attraction between the polyelectrolyte components accompanied with other associative interactions, such as hydrogen-bonding, hydrophobic interaction, charge-transfer and so on. The LbL self-assembly technique has been a powerful tool for micro/nano-encapsulation. Our strategy is to fabricate the nano-multilayer wall for micro-and sub-microcapsules by the LbL of polyelectrolytes, particularly natural polymers chitosan (CHI) and alginate (ALG) for drug controlled release. Our recent work following this strategy is reviewed in the present article. After determining the charge density threshold for the LbL assembly, we immobilised enzymes of urease and superoxide dismutase on polystyrene nanoparticles through the LbL and found the decrease in enzyme bioactivity but an increase in their storage stability. We successfully fabricated the nanocapsules from natural polysaccharides of CHI and ALG multilayers by the LbL for drug release. The LbL self-assembly of CHI and ALG was used directly on indomethacin (IDM) microcrystals to reduce the release rate. We observed that increasing deposition temperature would produce a more perfect multilayer film with higher thickness and reduced the release rate efficiently. Water soluble protein insulin was spontaneously loaded into the LbL CHI/ALG microcapsules due to the electrostatic attraction and a two-temperature loading procedure was suggested to increase the loading capacity and to reduce the release rate. The LbL multilayers have been used to encapsulate the drug-loading microparticles made from solvent evaporation or adsorption with porous CaCO 3 microparticles to enhance the loading capacity and suppress the initial burst. Increasing the layer number, raising the deposition temperature, and cross-linking the neighboring layers were confirmed to slow down the enzymatic desorption of polyelectrolyte multilayer films and the release rate of encapsulated drug effectively.

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Controlled Release of Dexamethasone from Microcapsules Produced by Polyelectrolyte Layer-by-Layer Nanoassembly

Abstract: Direct surface modification of dexamethasone microcrystals via the LbL process produced monodispersed suspensions with diffusion-controlled sustained drug release via the polyelectrolyte multilayer shell.

Cited by 100 publications

References 25 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings

Microcapsules for controlled release fabricated via layer-by-layer self-assembly of polyelectrolytes

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