Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings

Knopf‐Marques, Helena; Singh, Sonali; Htwe, Su Su; Wolfová, Lucie; Buffa, Radovan; Bacharouche, Jalal; Francius, Grégory; Voegel, Jean‐Claude; Schaaf, Pierre; Ghaemmaghami, Amir M.; Vrana, Nihal Engin; Lavalle, Philippe

doi:10.1021/acs.biomac.6b00429

Cited by 31 publications

(29 citation statements)

References 46 publications

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“…One of the most widely used L‐b‐L film formulation with HA is based on poly‐L‐Lysine (PLL, polycation) and HA (polyanion) which was first developed in our laboratory, as shown in Figure c–e. A large and continuous green fluorescent zone demonstrates that the PLL has diffused within the whole film.…”

Section: Use Of Ha and Its Derivatives In Coatings Polyelectrolyte Mmentioning

confidence: 99%

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

Knopf‐Marques

Pravda

Wolfová

et al. 2016

Adv Healthcare Materials

Self Cite

171

159

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epithelial, connective, and nerve tissues of vertebrates. It is designated as a glycosaminoglycan. [1] Glycosaminoglycans are composed of disaccharide blocks of N-acetylgalactosamine or N-acetylglucosamine, (amino sugars) and uronic sugars such as glucuronic acid, iduronic acid or galactose. This group of heteropolysaccharides comprises HA, chondroitin sulfates, dermatan sulfate, heparin and heparin sulfates whose sulfation degree is less than that of heparin. Unlike other glycosaminoglycans, hyaluronan is not sulfated and it is self-standing, i.e. without an association with a core protein. [2] It was isolated in 1934 by Meyer and Palmer from bovine vitreous humor. [3] The polymer chain of hyaluronan comprises repeating disaccharide units where the pyranose rings are connected by β-1,3 bonds. The repeating units are bonded with a β-1,4 glycosidic bond within the chain between N-acetyl-D-glucosamine and D-glucuronic acid. At physiological pH each glucuronate unit, associated with its carboxylate group, carries an anionic charge. The hundreds of negative charges are fixed to each chain. These anionic groups are balanced with mobile cations such as Na + , K + , Ca 2+ and Mg 2+ . During ionization of D-glucuronic acid with the carboxylic groups, the charges influence the organization of the chains and their interactions with their surroundings. In turn, they are affected by pH and ionic strength. The chain organization and charge directly affect the solubility in water, since hyaluronan is water-insoluble when convertedAs an Extracellular Matrix (ECM) component, Hyaluronic acid (HA) plays a multi-faceted role in cell migration, proliferation and differentiation at micro level and system level events such as tissue water homeostasis. Among its biological functions, it is known to interact with cytokines and contribute to their retention in ECM microenvironment. In addition to its biological functions, it has advantageous physical properties which result in the industrial endeavors in the synthesis and extraction of HA for variety of applications ranging from medical to cosmetic. Recently, HA and its derivatives have been the focus of active research for applications in biomedical device coatings, drug delivery systems and in the form of scaffolds or cell-laden hydrogels for tissue engineering. A specific reason for the increase in use of HA based structures is their immunomodulatory and regeneration inducing capacities. In this context, this article reviews recent literature on modulation of the implantable biomaterial microenvironment by systems based on HA and its derivatives, particularly hydrogels and microscale coatings that are able to deliver cytokines in order to reduce the adverse immune reactions and promote tissue healing.

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Section: Use Of Ha and Its Derivatives In Coatings Polyelectrolyte Mmentioning

confidence: 99%

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

Knopf‐Marques

Pravda

Wolfová

et al. 2016

Adv Healthcare Materials

Self Cite

171

159

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“…More attention has been dedicated to the electrical stimulation parameters of these neurostimulators since they are relatively biocompatible. Nonetheless, further modifications to electrode surfaces, such as cross-linking polyelectrolyte films, 88 neural stem cell-seeded electrodes, and fibrin hydrogel coatings, have been tested to varying degrees of efficacy in improving the stimulation, recording, and biocompatibility profiles of neurostimulators. 89 Efforts to improve the biocompatibility of implantable electrodes are ongoing, and range from developing new electrode materials, substrates, and coatings that can enhance electrode longevity and functionality.…”

Section: )mentioning

confidence: 99%

Functional and Histological Effects of Chronic Neural Electrode Implantation

Sahyouni

Chang

Moshtaghi

et al. 2017

Laryngoscope Investig Oto

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ObjectivesPermanent injury to the cranial nerves can often result in a substantial reduction in quality of life. Novel and innovative interventions can help restore form and function in nerve paralysis, with bioelectric interfaces among the more promising of these approaches. The foreign body response is an important consideration for any bioelectric device as it influences the function and effectiveness of the implant. The purpose of this review is to describe tissue and functional effects of chronic neural implantation among the different categories of neural implants and highlight advances in peripheral and cranial nerve stimulation. Data Sources: PubMed, IEEE, and Web of Science literature search. Review Methods: A review of the current literature was conducted to examine functional and histologic effects of bioelectric interfaces for neural implants.ResultsBioelectric devices can be characterized as intraneural, epineural, perineural, intranuclear, or cortical depending on their placement relative to nerves and neuronal cell bodies. Such devices include nerve‐specific stimulators, neuroprosthetics, brainstem implants, and deep brain stimulators. Regardless of electrode location and interface type, acute and chronic histological, macroscopic and functional changes can occur as a result of both passive and active tissue responses to the bioelectric implant.ConclusionA variety of chronically implantable electrodes have been developed to treat disorders of the peripheral and cranial nerves, to varying degrees of efficacy. Consideration and mitigation of detrimental effects at the neural interface with further optimization of functional nerve stimulation will facilitate the development of these technologies and translation to the clinic.Level of Evidence3.

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“…While this vein of research has garnered interest for particulate systems (see Section 3), interest in the tissue engineering field is just arising over the past few years. New studies are investigating how shape, composition, and charge of tissue engineering constructs impact the immune response . For example, polymeric scaffolds have been synthesized by electrospinning polycaprolactone, then the resulting fibers were modified to exhibit different shapes .…”

Section: Tissue Engineering Constructs Exhibit Intrinsic Immunogenicitymentioning

confidence: 99%

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

Andorko

Jewell

2017

Bioengineering & Transla Med

158

123

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Recent research in the vaccine and immunotherapy fields has revealed that biomaterials have the ability to activate immune pathways, even in the absence of other immune‐stimulating signals. Intriguingly, new studies reveal these responses are influenced by the physicochemical properties of the material. Nearly all of this work has been done in the vaccine and immunotherapy fields, but there is tremendous opportunity to apply this same knowledge to tissue engineering and regenerative medicine. This review discusses recent findings that reveal how material properties—size, shape, chemical functionality—impact immune response, and links these changes to emerging opportunities in tissue engineering and regenerative medicine. We begin by discussing what has been learned from studies conducted in the contexts of vaccines and immunotherapies. Next, research is highlighted that elucidates the properties of materials that polarize innate immune cells, including macrophages and dendritic cells, toward either inflammatory or wound healing phenotypes. We also discuss recent studies demonstrating that scaffolds used in tissue engineering applications can influence cells of the adaptive immune system—B and T cell lymphocytes—to promote regenerative tissue microenvironments. Through greater study of the intrinsic immunogenic features of implantable materials and scaffolds, new translational opportunities will arise to better control tissue engineering and regenerative medicine applications.

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Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings

Cited by 31 publications

References 46 publications

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

Functional and Histological Effects of Chronic Neural Electrode Implantation

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

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