Controlled release of copper from an intrauterine device using a biodegradable polymer

Ramakrishnan, Reshmi; Bharaniraja, B; Aprem, Abi Santhosh

doi:10.1016/j.contraception.2015.08.014

Cited by 22 publications

(3 citation statements)

References 19 publications

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“…The risk of copper‐induced toxicity can be reduced by slowing the release of copper ions. [ 25,31,32 ] Coating with materials such as metal‐organic frameworks (MOFs) and polymers could be the best approach to reducing its toxicity while maintaining antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Copper@ZIF‐8 Core‐Shell Nanowires for Reusable Antimicrobial Face Masks

Kumar

Sharma

Chen

et al. 2020

Adv Funct Materials

117

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SARS‐CoV‐2 and other respiratory viruses spread via aerosols generated by infected people. Face masks can limit transmission. However, widespread use of disposable masks consumes tremendous resources and generates waste. Here, a novel material for treating blown polypropylene filtration media used in medical‐grade masks to impart antimicrobial activity is reported. To produce thin copper@ZIF‐8 core‐shell nanowires (Cu@ZIF‐8 NWs), Cu NWs are stabilized using a pluronic F‐127 block copolymer, followed by growth of ZIF‐8 to obtain uniform core‐shell structures. The Cu@ZIF‐8 NWs are applied to filtration media by dip coating. Aerosol filtration efficiency decreases upon exposure to ethanol (solvent for dip‐coating), but increases with addition of Cu@ZIF‐8 NWs. Cu@ZIF‐8 NWs shows enhanced antibacterial activity, compared to Cu NWs or ZIF‐8 alone, against Streptococcus mutans and Escherichia coli . Antiviral activity against SARS‐CoV‐2 is assayed using virus‐infected Vero E6 cells, demonstrating 55% inhibition of virus replication after 48 h by 1 µg of Cu@ZIF‐8 NWs per well. Cu@ZIF‐8 NWs’ cytotoxicity is tested against four cell lines, and their effect on inflammatory response in A549 cells is examined, demonstrating good biocompatibility. This low‐cost, scalable synthesis and straightforward deposition of Cu@ZIF‐8 NWs onto filter media has great potential to reduce disease transmission, resource consumption, and environmental impact of waste.

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Section: Introductionmentioning

confidence: 99%

Copper@ZIF‐8 Core‐Shell Nanowires for Reusable Antimicrobial Face Masks

Kumar

Sharma

Chen

et al. 2020

Adv Funct Materials

117

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“…When developing strategies to address this problem, technologies that avoid the use of pharmaceuticals or biologics are attractive to lower product development costs and reduce time to market. Of particular interest is the use of copper ion (Cu 2+ ), as it has been shown to stimulate angiogenesis and collagen deposition processes that lead to improved wound healing. − However, multiple applications of copper salts and copper oxide are necessary, increasing the risk of copper-induced toxicity to the patient. − However, the risk of copper ion toxicity can be reduced if the ion is slowly released. − …”

mentioning

confidence: 99%

Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes

et al. 2018

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The successful treatment of chronic nonhealing wounds requires strategies that promote angiogenesis, collagen deposition, and re-epithelialization of the wound. Copper ions have been reported to stimulate angiogenesis; however, several applications of copper salts or oxides to the wound bed are required, leading to variable outcomes and raising toxicity concerns. We hypothesized that copper-based metal-organic framework nanoparticles (Cu-MOF NPs), referred to as HKUST-1, which are rapidly degraded in protein solutions, can be modified to slowly release Cu, resulting in reduced toxicity and improved wound healing rates. Folic acid was added during HKUST-1 synthesis to generate folic-acid-modified HKUST-1 (F-HKUST-1). The effect of folic acid incorporation on NP stability, size, hydrophobicity, surface area, and copper ion release profile was measured. In addition, cytotoxicity and in vitro cell migration processes due to F-HKUST-1 and HKUST-1 were evaluated. Wound closure rates were assessed using the splinted excisional dermal wound model in diabetic mice. The incorporation of folic acid into HKUST-1 enabled the slow release of copper ions, which reduced cytotoxicity and enhanced cell migration in vitro. In vivo, F-HKUST-1 induced angiogenesis, promoted collagen deposition and re-epithelialization, and increased wound closure rates. These results demonstrate that folic acid incorporation into HKUST-1 NPs is a simple, safe, and promising approach to control Cu release, thus enabling the direct application of Cu-MOF NPs to wounds.

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“…PLGA is also used to coat copper intrauterine device, which participated in reduction of initial burst copper release compared to uncoated devices [19]. Another design of system is directed toward relieving the pain caused by insertion of copper intrauterine device.…”

Section: Intrauterine Device (Iud)mentioning

confidence: 99%

Applications of advanced biomaterials for the development of contraception

Ashraf,

El-Sawy

2024

ERU Research Journal

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Unplanned pregnancy incidence is currently a staggering number, which almost represents half of the total population worldwide according to what reported from the United Nation Population Fund (UNFPA) in 2022. Several factors could contribute to the unintended pregnancy including lack of reproductive health care and contraceptive options that don't suit all family circumstances, in addition to related side effects, menstrual disorder and lifelong infertility. Biomaterial-based contraception has gained much attention in the last few years due to its improved role in controlling drug delivery routes. In this mini review, we will discuss and mention the recent interventions and progress of conventional and advanced biomaterials-based contraceptives for long acting contraception goals. This includes subcutaneous implants, transdermal patches and microneedles, orally administered contraceptive loaded delivery systems, intravenous administration and intrauterine devices. In addition, the role of biomaterials in improving sterilization methods such as tubal ligation and vasectomy, has been also emphasized in this review.

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Controlled release of copper from an intrauterine device using a biodegradable polymer

Abstract: Coating a CuT380 IUD with biodegradable polymer reduced the initial copper release without affecting release at 1 year. Clinical trials are required to determine whether this could reduce side effects such as bleeding and pain associated with copper containing IUDs.

Cited by 22 publications

References 19 publications

Copper@ZIF‐8 Core‐Shell Nanowires for Reusable Antimicrobial Face Masks

Copper@ZIF‐8 Core‐Shell Nanowires for Reusable Antimicrobial Face Masks

Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes

Applications of advanced biomaterials for the development of contraception

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