Controlled release of bovine serum albumin from stimuli‐sensitive silk sericin based interpenetrating polymer network hydrogels

Wu, Wen; Wang, Dongsheng; Lian, Yuan

doi:10.1002/pi.4429

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…The BSA release experiments were conducted by immersing the BSA‐loaded hydrogel in 100 mL of the 0.2 mol L −1 phosphate buffered saline solution, and the solution was then placed in a shaking water bath. At desired time intervals during the in vitro release experiment, 4 mL buffer solution was taken from the release experiment and 4 mL fresh buffer solution was added back to maintain constant sample volume . The amount of BSA released from the BSA‐loaded hydrogel was determined with a UV − visible spectrophotometer.…”

Section: Methodsmentioning

confidence: 81%

“…At desired time intervals during the in vitro release experiment, 4 mL buffer solution was taken from the release experiment and 4 mL fresh buffer solution was added back to maintain constant sample volume. 51 The amount of BSA released from the BSA-loaded hydrogel was determined with a UV − visible spectrophotometer. The drug cumulative release was calculated using the equation…”

Section: In Vitro Release Of Bovine Serum Albumin (Bsa) From Hydrogelmentioning

confidence: 99%

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Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry

Sheng

Liu

et al. 2015

Polymer International

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A novel temperature responsive copolymer, poly[2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate-co-N-hydroxymethyl acrylamide] [P(MEO 2 MA-co-OEGMA-co-HMAM)], was synthesized by atom transfer radical polymerization. pH responsive poly(methacrylic acid) (PMAA) was synthesized by reversible addition-fragmentation chain transfer polymerization. After the hydroxyl groups on P(MEO 2 MA-co-OEGMA-co-HMAM) were transformed into azide groups and the carboxyl groups on PMAA were transformed into alkyne groups respectively, a novel temperature and pH responsive hydrogel was fabricated by click chemistry between the azide-P(MEO 2 MA-co-OEGMA-co-HMAM) and alkyne-PMAA in the presence of CuSO 4 and sodium ascorbate in aqueous solution. The rheological kinetics of gel formation demonstrated that gelation had commenced within 5 min at 25 ∘ C, since then the storage modulus (G ′ ) was higher than the loss modulus (G ′′ ). SEM images of hydrogel morphology and the swelling ratios of hydrogel at different temperatures and pH proved that the formed hydrogel had temperature and pH sensitivities. Bovine serum albumin was used as a model to evaluate the sustained release of the hydrogel; the results indicated that the hydrogel was a promising candidate for controlling protein drug delivery.

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Section: Methodsmentioning

confidence: 81%

Section: In Vitro Release Of Bovine Serum Albumin (Bsa) From Hydrogelmentioning

confidence: 99%

Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry

Sheng

Liu

et al. 2015

Polymer International

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“…In recent years, the use of stimuli-sensitive interpenetrating polymer network (IPN) hydrogels for the encapsulation and controlled release of protein drugs has received significant attention. Release of bovine serum albumin, a model drug, from a series of thermosensitive silk sericin poly (N-isopropylacrylamide) and pH-responsive sericin-poly(methacrylic acid) IPN hydrogels has been explored [54]. The pulsatile releasing behavior of IPN hydrogels reveals that they can be made into microcapsules or thermo-valves, which act as an on-off release control.…”

Section: (C) Hydrogelsmentioning

confidence: 99%

Silk Protein Sericin: Promising Biopolymer for Biological and Biomedical Applications

Nayak

Kundu

2016

Biomaterials From Nature for Advanced Devices and Therapies

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“…poly(N-isopropylacrylamide) IPN hydrogels [7]. A polyacrylamide grafted carrageenan and sodium alginate IPN was synthesized and represented a pH-responsive hydrogel used for targeting ketoprofen to the intestines [8].…”

Section: Introductionmentioning

confidence: 99%

A polymer hybrid film based on poly(vinyl cinnamate) and poly(2-hydroxy ethyl methacrylate) for controlled flurbiprofen release

Alokour

Yilmaz

2021

J Polym Res

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A crosslinked polymer hybrid film, ipn-poly(vinyl cinnamate-graft-2-hydroxy ethyl methacrylate)-v-poly(ethylene glycol dimethacrylate) was synthesized by UV initiation using poly(vinyl cinnamate) (polyVCi), 2-hydroxy ethyl methacrylate (HEMA) monomer and ethylene glycol dimethacrylate (EGDMA) crosslinker. Benzophenone (Ph 2 CO), was used as the photoinitiator. The synthesis was optimized by changing the concentration of HEMA, Ph 2 CO, EGDMA, and UV irradiation time. PolyVCi undergoes photocrosslinking by 2 + 2 photocylo addition while the monomer/crosslinker couple, HEMA/ EGDMA, undergoes free radical polymerization and crosslinking to form EGDMA crosslinked polyHEMA. Hence, simultaneous interpenetrating polymer network (IPN) formation occurs. The IPN consists of dual network of photocrosslinked polyVCi and EGDMA crosslinked polyHEMA chains. Grafting of HEMA/EGDMA chains on the polyVCi backbone also occur during network formation. The chemical functionalities present in the polyVCi/polyHEMA/polyEGDMA IPN films obtained were characterized by FTIR and SEM analysis. The contact angle measurements show enhanced wettability of the IPN film compared to polyVCi surface. TGA analysis confirms thermal stability of the films. Swelling behavior of the films examined in water and in ethanol reveals the effects of the chemical natures of polyVCi and polyHEMA as well as that of crosslinking on the hydrophilicity of the film. The films were tested as drug release matrices using flurbiprofen. The drug was loaded into the film matrix during IPN formation under UV irradiation. PolyVCi/polyHEMA/polyEGDMA IPN proved to be a suitable release matrix for flurbiprofen demonstrating controlled release behavior and zero-order release kinetics. The release mechanism was confirmed by its Ritger-Peppas "n" value (1.00 to 1.42), which indicates super case II release.

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Controlled release of bovine serum albumin from stimuli‐sensitive silk sericin based interpenetrating polymer network hydrogels

Cited by 8 publications

References 37 publications

Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry

Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry

Silk Protein Sericin: Promising Biopolymer for Biological and Biomedical Applications

A polymer hybrid film based on poly(vinyl cinnamate) and poly(2-hydroxy ethyl methacrylate) for controlled flurbiprofen release

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