Controlled release of BMP-2 from titanium with electrodeposition modification enhancing critical size bone formation

Teng, Fu-Yuan; Tai, I-Chun; Ho, Mei-Ling; Wang, Jhe-Wen; Weng, Li Wen; Wang, Yue Jun; Wang, Min-Wen; Tseng, Chun-Chieh

doi:10.1016/j.msec.2019.109879

Cited by 43 publications

(29 citation statements)

References 36 publications

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“…In addition, a sustained release over time from a confined compartment not only assures a long-term ongoing osteogenic activity, but also provides maximum efficacy (being the delivery system directed specifically to the targeted cell pools) as well as mimics the physiological mode Dental implant healing in an osteopenic environment of growth factor release from the bone matrix during bone remodelling (Liu et al, 2018;Liu et al, 2005). Other approaches to deal with the enhancement and acceleration of bone formation and implant osseointegration under osteopenic/osteoporotic conditions have been described, such as the local delivery of BMP-4 (Lai et al, 2011), the use of injectable tricalcium phosphate (TCP)-microspheres associated with BMP-2 (Chang et al, 2017), the local application of anti-cytokine antibodies (Yang et al, 2020) or the use of systemic sclerostin antibody treatment (Korn et al, 2019;Virdi et al, 2015). Another approach suggested relates to the presurgical injection of BMP-7 in a slow-release system [polyglycolic acid (PLGA)-microspheres] to initially build up local bone structure before implant placement (Phillips et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, they are currently used at very high dosages, being able, given their pleomorphic nature (common to many growth factors), to elicit opposite effects depending on the concentration at which they reach the target cells (James et al, 2016). Given such undesired effects, several slow drugrelease systems have been developed and applied for BMPs to reduce the concentrations of the drug and to prolong its effects in time (Gruber et al, 2009;Liu et al, 2006a;Maisani et al, 2018;Teng et al, 2019;Venkatesan et al, 2019). The present study used a BMP confined in a carrier that prevented the interaction with unintentionally targeted cell populations, thus EB Hunziker et al…”

Section: Experimental Implantmentioning

confidence: 98%

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The slow release of BMP-7 at a low dose accelerates dental implant healing in an osteopenic environment

Hunziker

Liu²,

Muff³

et al. 2021

eCM

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The aim of the present study was to investigate in vivo whether bone morphogenetic protein-7 (BMP-7) was able to promote and accelerate dental implant healing at a low dose in an osteopenic environment by using a delayed drug-release system. Skeletally mature Chinese goats, having physiologically osteopenic (osteoporotic-like) facial bones, served as an animal model. Dental implants were provided with a delayed-release drug-delivery system and BMP-7 was applied at three different dosages. The implants, inserted into healed extraction sockets, were removed 1, 2 and 3 weeks after surgery. Quantification of osseointegration and formation of new bone in the peri- implant space were measured histomorphometrically. Data revealed no evidence of any adverse drug effect at or near the implantation sites. After the first postoperative week, bone neoformation was minimal; after the second week, peri-implant bone formation appeared, particularly in the groups with low dosages of BMP-7. After 3 weeks, new-bone volume was the largest in the group with the lowest (near-physiological) dosage of BMP-7, also showing the highest efficacy of BMP-7. Other dosage or release modes were found to be significantly less effective. BMP-7 was highly efficacious in promoting and accelerating bone formation in the peri-implant space in a hostile osteopenic environment if released by a slow-mode mechanism over time at near physiological activities. Therefore, biological functionalisation of dental implants by a high-power osteogenic factor may improve their healing success in hostile bony environments (osteopenia, osteoporosis, bone atrophy etc.).

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Implantmentioning

confidence: 98%

The slow release of BMP-7 at a low dose accelerates dental implant healing in an osteopenic environment

Hunziker

Liu²,

Muff³

et al. 2021

eCM

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“…We identified 10 candidate genes (Figure 5 and Supplementary Table S5), including three brain and nerve development related genes (CCDC85A, LY6H, and TMEM424), four genes involved in bone formation (USP34, BMP2, CDH5, and STC1) and three genes associated with disease resistance (ETAA1, PLEK, and ZNF622). Interestingly, USP34 is required for osteogenic differentiation and bone formation (Guo et al, 2018), BMP2 encodes bone morphogenetic protein 2 and regulates osteoinduction both in vitro and in vivo (Wang D. et al, 2019;Teng et al, 2019), CDH5 in acetabular labrum cells may be involved in the pathogenesis of osteoarthritis Horizontal branch lengths are proportional to the amount of genetic drift that occurred on the branch. The scale bar shows 10 times the average standard error of the entries in the sample covariance matrix.…”

Section: Candidate Genes Under Selection For Body Size In Meishan Pigsmentioning

confidence: 99%

Genome Data Uncover Conservation Status, Historical Relatedness and Candidate Genes Under Selection in Chinese Indigenous Pigs in the Taihu Lake Region

Liu

Zhou

et al. 2020

Front. Genet.

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Chinese indigenous pig breeds in the Taihu Lake (TL) region of Eastern China are well documented by their exceptional prolificacy. There are seven breeds in this region including Meishan (MS), Erhualian (EHL), Jiaxing Black (JXB), Fengjing (FJ), Shawutou (SWT), Mi (MI), and Hongdenglong (HDL). At present, these breeds are facing a great threat of population decline, inbreeding depression and lineage admixture since Western commercial pigs have dominated in Chinese pig industry. To provide better conservation strategies and identify candidate genes under selection for these breeds, we explored genome-wide single nucleotide polymorphism (SNP) markers to uncover genetic variability and relatedness, population structure, historical admixture and genomic signature of selection of 440 pigs representing the most comprehensive lineages of these breeds in TL region in a context of 1228 pigs from 45 Eurasian breeds. We showed that these breeds were more closely related to each other as compared to other Eurasian breeds, defining one of the main ancestral lineages of Chinese indigenous pigs. These breeds can be divided into two subgroups, one including JXB and FJ, and the other comprising of EHL, MI, HDL, MS, and SWT. In addition, HDL was highly inbred whereas EHL and MS had more abundant genetic diversity owing to their multiple conservation populations. Moreover, we identified a list of candidate genes under selection for body size and prolificacy. Our results would benefit the conservation of these valuable breeds and improve our understanding of the genetic mechanisms of body size and fecundity in pigs.

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“…The vancomycin coating helps to prevent the bacteria colonization caused by the high surface area to volume ratio of porous Ti implants [ 82 ]. On the other hand, a high surface area/volume ratio is beneficial for drug sustained release, such as BMP-2 and silver nanoparticles [ 84 ].…”

Section: Metallic Nanomaterialsmentioning

confidence: 99%

Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration

Cui

Luo

et al. 2021

Nanomaterials

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Extensive bone defect repair remains a clinical challenge, since ideal implantable scaffolds require the integration of excellent biocompatibility, sufficient mechanical strength and high biological activity to support bone regeneration. The inorganic nanomaterial-based therapy is of great significance due to their excellent mechanical properties, adjustable biological interface and diversified functions. Calcium–phosphorus compounds, silica and metal-based materials are the most common categories of inorganic nanomaterials for bone defect repairing. Nano hydroxyapatites, similar to natural bone apatite minerals in terms of physiochemical and biological activities, are the most widely studied in the field of biomineralization. Nano silica could realize the bone-like hierarchical structure through biosilica mineralization process, and biomimetic silicifications could stimulate osteoblast activity for bone formation and also inhibit osteoclast differentiation. Novel metallic nanomaterials, including Ti, Mg, Zn and alloys, possess remarkable strength and stress absorption capacity, which could overcome the drawbacks of low mechanical properties of polymer-based materials and the brittleness of bioceramics. Moreover, the biodegradability, antibacterial activity and stem cell inducibility of metal nanomaterials can promote bone regeneration. In this review, the advantages of the novel inorganic nanomaterial-based therapy are summarized, laying the foundation for the development of novel bone regeneration strategies in future.

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Controlled release of BMP-2 from titanium with electrodeposition modification enhancing critical size bone formation

Cited by 43 publications

References 36 publications

The slow release of BMP-7 at a low dose accelerates dental implant healing in an osteopenic environment

The slow release of BMP-7 at a low dose accelerates dental implant healing in an osteopenic environment

Genome Data Uncover Conservation Status, Historical Relatedness and Candidate Genes Under Selection in Chinese Indigenous Pigs in the Taihu Lake Region

Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration

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