Controlled release of biologically active agents for purposes of agricultural crop management

Mogul, Marc Gregory; Akin, Hanife; Hasırcı, Nesrin; Trantolo, Debra J.; Gresser, Joseph D.; Wise, Donald L.

doi:10.1016/0921-3449(95)00063-1

Cited by 133 publications

(83 citation statements)

References 30 publications

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“…35 Several studies have demonstrated that the incorporation of essential oils into SLNs helps to increase their stability. 36,37 To investigate the capability of SLNs to prevent the rapid evaporation of FMO, six components that possess different boiling points according to the established GC spectrum were chosen as the indexed components.…”

Section: In Vitro Evaporation Releasementioning

confidence: 99%

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Shi

Zhao²,

Liu³

et al. 2012

IJN

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Abstract:The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of −16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.

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Section: In Vitro Evaporation Releasementioning

confidence: 99%

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Shi

Zhao²,

Liu³

et al. 2012

IJN

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“…Different studies have shown that the rapid evaporation, leaching, and degradation of some active substances can lead to a dramatic decrease of formulation performance. 33,34 For this reason pesticides have been encapsulated into different microcapsules or microspheres of different polymers. 33,34 Several studies have shown that the incorporation of volatile compounds into SLN prevents their rapid evaporation.…”

Section: In Vitro Releasementioning

confidence: 99%

Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization

et al. 2006

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The aim of this study was to formulate a new delivery system for ecological pesticides by the incorporation of Artemisia arborescens L essential oil into solid lipid nanoparticles (SLN). Two different SLN formulations were prepared following the high-pressure homogenization technique using Compritol 888 ATO as lipid and Poloxamer 188 or Miranol Ultra C32 as surfactants. The SLN formulation particle size was determined using Photon correlation spectroscopy (PCS) and laser diffraction analysis (LD). The change of particle charge was studied by zeta potential (ZP) measurements, while the melting and recrystallization behavior was studied using differential scanning calorimetry (DSC). In vitro release studies of the essential oil were performed at 35°C. Data showed a high physical stability for both formulations at various storage temperatures during 2 months of investigation. In particular, average diameter of Artemisia arborescens L essential oil-loaded SLN did not vary during storage and increased slightly after spraying the SLN dispersions. In vitro release experiments showed that SLN were able to reduce the rapid evaporation of essential oil if compared with the reference emulsions. Therefore, obtained results showed that the studied SLN formulations are suitable carriers in agriculture.

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“…It can be attributed mainly to residual pesticide in soils. Since controlled-release systems would not release the AI at once, this therefore lowers the pesticide residues in soil and thus reduces the phytotoxicity (Mogul et al 1996).…”

Section: Controlled-release Agrochemical Delivery Systems and Their Amentioning

confidence: 99%

Polysaccharides as safer release systems for agrochemicals

Campos

Oliveira

Fraceto

et al. 2014

Agron. Sustain. Dev.

277

197

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Agrochemicals are used to improve the production of crops. Conventional formulations of agrochemicals can contaminate the environment, in particular in the case of intensive cropping. Hence, there is a need for controlledrelease formulations of agrochemicals such as polysaccharides to reduce pollution and health hazards. Natural polysaccharides are hydrophilic, biodegradable polymers. This article reviews the use of polysaccharides in the form of micro-and nanoparticles, beads and hydrogels. The main points are: (1) slow release formulations minimize environmental impact by reducing agrochemical leaching, volatilization and degradation. For example, 50 % of the encapsulated insecticide chlorpyrifos is released in 5 days, whereas free chlorpyrifos is released in 1 day. (2) Slow release formulations increase the water-holding capacity of soil. (3) Slow release formulations better control weeds in the long run. (4) Polymer-clay formulations store ionic plant nutrients. (5) Polymer hydrogel formulations reduce compaction, erosion, and water run-off. They increase soil permeability and aeration, infiltration rates, and microbial activity, and, in turn, plant performance. In conclusion, polysaccharide formulations can be used for safer use of agrochemicals.

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Controlled release of biologically active agents for purposes of agricultural crop management

Cited by 133 publications

References 30 publications

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization

Polysaccharides as safer release systems for agrochemicals

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