Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: Analysis of drug and water diffusion processes with X-ray-based methods

Microparticles Formulation as a Targeting Drug Delivery System

“…In this case, the methylcellulose dissolves out of the film leaving small channels in the film through which drug can diffuse. The ethyl cellulose barrier left on the particle serves as restraining barrier to maintain constant diffusion area and constant diffusion path length [29][30][31][32].…”

“…With coated products, one can obtain pulsed dosing effects i.e., repeat action, by merely employing a small number of different thickness coated particles, or obtaining the more common sustained effect by utilizing a spectrum of different thickness coatings. Some granules within each group release the drug at intervals overlapping other groups, resulting in a smooth rather than discontinuous release, profile [29][30][31][32].…”

Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies

“…These droplets are subsequently cooled down by falling through a tempered cooling tower and gathered as spheres with narrow size distribution. Main drawback of HME and prilling is the requirement of higher processing temperatures, which are in general not suitable for thermo-labile compounds [Ceowley et al, 2007;Lang et al, 2014;Maniruzzaman et al, 2012;Pivette et al, 2012;Repka et al, 2007;Repka et al, 2012;Sequier et 4 al., 2014;Vervaeck et al, 2013]. Pharmaceutically approved lipids are excipients suitable for production of solid oral dosage forms by melting technologies, due to their biocompatibility, lowtoxicity, compatibility with many active compounds, moderate melting temperatures and low cost.…”

Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques

“…As lipid-based formulations can be processed using different techniques (direct compression, melt granulation, melt extrusion, molding, spray congealing/prilling, solid lipid extrusion, hot-melt coating), this paper evaluates the impact of 2 continuous processing techniques (prilling and solid lipid extrusion) on the characteristics of multiparticulate fatty acid-based formulations. In contrast to prilling where the entire lipid fraction must be molten to obtain a liquid with adequate viscosity for pumping through a calibrated nozzle to create droplets [8,9], solid lipid extrusion (SLE) operates below the melting point of the lipid component. Via a thermo-mechanical treatment at moderate pressure and temperature, the mass is sufficiently plasticized to mold it through the die of the extruder [1].…”