Controlled release of 5-fluorouracil to melanoma cells using a hydrogel/micelle composites based on deoxycholic acid and carboxymethyl chitosan

Pourmanouchehri, Zahra; Ebrahimi, Sayeh; Limoee, Mazdak; Jalilian, Fereshteh; Janfaza, Sajad; Vosoughi, Amirhossein; Behbood, Leila

doi:10.1016/j.ijbiomac.2022.02.096

Cited by 15 publications

(11 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43 Although CS multiscale delivery systems have not been investigated in IVD tissue engineering, delivery systems consisting of deoxycholic acid micelle particles and carboxymethyl chitosan (CMCS) hydrogels deliver controlled release of 5-fluorouracil into melanoma cells. 44 Huang et al 45 constructed multifunctional hydrogels based on poly-dopamine (PDA) and methacrylate-chitosan by incorporating fluorinated nanoparticles. The multifunctional hydrogel CS/HAp@PDA-F multiscale delivery system, which has anti-infective properties and provides timely and continuous oxygen to the IVDD microenvironment, allows bone marrow mesenchymal stem cells (BMSCs) to adhere and proliferate and maintains their osteogenic differentiation potential.…”

Section: Stimulus-responsive Composite Hydrogelsmentioning

confidence: 99%

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Gao

Zhang

et al. 2022

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Section: Stimulus-responsive Composite Hydrogelsmentioning

confidence: 99%

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Gao

Zhang

et al. 2022

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Meanwhile, since melanoma is located between the dermis and epidermis, high molecular weight and hydrophilic biomolecules have poor penetration into the skin’s stratum corneum—5-FU needs a desired, effective method to deliver therapeutic drugs to the site. To address this issue, Pourmanouchehri et al designed a pH-sensitive micellar hydrogel system based on deoxycholic acid micelles and carboxymethyl chitosanhydrogels to improve 5-FU efficacy against skin cancer and reduce its systemic side effects by enhancing its delivery to the skin [ 113 ].…”

Section: Cutaneous Melanomamentioning

confidence: 99%

Advances in the Application of Nanomaterials to the Treatment of Melanoma

Wang

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Melanoma can be divided into cutaneous melanoma, uveal melanoma, mucosal melanoma, etc. It is a very aggressive tumor that is prone to metastasis. Patients with metastatic melanoma have a poor prognosis and shorter survival. Although current melanoma treatments have been dramatically improved, there are still many problems such as systemic toxicity and the off-target effects of drugs. The use of nanoparticles may overcome some inadequacies of current melanoma treatments. In this review, we summarize the limitations of current therapies for cutaneous melanoma, uveal melanoma, and mucosal melanoma, as well as the adjunct role of nanoparticles in different treatment modalities. We suggest that nanomaterials may have an effective intervention in melanoma treatment in the future.

show abstract

“…Therefore, the maximum amount of drug retention in the lower layer of the skin is required to treat these skin diseases [ 3 ]. In managing topical lesions such as skin cancers and actinic keratosis, 5-fluorouracil (5-FU) is widely used [ 4 ]. One of the major problems of 5-FU is its poor permeability preventing the achievement of the therapeutic concentration via conventional dosage forms such as solutions, ointments or creams [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chitosan-Decorated Nanoemulsion Gel of 5-Fluorouracil for Topical Delivery

Nawaz

Latif

Alnuwaiser

et al. 2022

Gels

View full text Add to dashboard Cite

(1) Background: The present study aimed to prepare chitosan-coated nanoemulsion gel containing 5-fluorouracil for enhanced topical delivery. (2) Methods: To formulate the nanoemulsion gel, oleic acid was used as the oil phase and Carbopol 940 as a gelling agent. Chitosan was used as a coating agent to control the release of 5-FU. Drug–excipient compatibility was evaluated using ATR-FTIR. The prepared nanoemulsion formulations were characterized based on particle size distribution, zeta potential, % encapsulation efficiency and drug content. In vitro drug release, skin drug retention and ex vivo permeation profiles were performed across rat skin using a Franz diffusion cell. Skin irritation experiments were also conducted on rats to examine the irritation potential of the formulations. (3) Results: It was found that the drug and excipients were compatible and chitosan successfully coated 5-FU, as demonstrated by ATR-FTIR results. The introduction of chitosan increased the size and zeta potential of the nanoemulsion. The 5-FU release in vitro was significantly lowered in the case of chitosan-decorated nanoemulsion (5-FU-C-NE), whereas the permeation and skin drug retention were higher in the case of 5-FU-C-NE. The formulations were proven non-irritant to the skin of the rats. The optimized formulation of the nanoemulsion was introduced into 1% Carbopol 940 gel. Incorporating the nanoemulsion into the gel further reduced the drug release in vitro and ex vivo permeation, whereas the retention of the drug in the skin was significantly increased (ANOVA; p < 0.05). The increase in skin retention was due to the presence of chitosan and Carbopol 940. The in vitro and ex vivo results were also confirmed with in vivo studies. Incorporating nanoemulsion into gel has resulted in higher Tmax, longer half-life and greater skin drug retention. (4) Conclusion: The results suggest that chitosan-decorated nanoemulsion gel is safe and can potentially be used to promote 5-FU skin retention, which is ideal for skin diseases such as melanoma.

show abstract

Controlled release of 5-fluorouracil to melanoma cells using a hydrogel/micelle composites based on deoxycholic acid and carboxymethyl chitosan

Cited by 15 publications

References 61 publications

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Advances in the Application of Nanomaterials to the Treatment of Melanoma

Synthesis and Characterization of Chitosan-Decorated Nanoemulsion Gel of 5-Fluorouracil for Topical Delivery

Contact Info

Product

Resources

About