Controlled release from protein particles encapsulated by molecular layer deposition

Vasudevan, Siddarth A.; Xu, Yaolin; Karwal, Saurabh; Meesters, G.M.H.; Talebi, Mojgan; Sudhölter, Ernst J. R.; Ommen, J. Ruud van

doi:10.1039/c5cc03232f

Cited by 16 publications

(12 citation statements)

References 28 publications

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“…New organic components have also been developed for the purely organic MLD processes; the MLD material library already includes, besides the initially introduced polyimides [ 15,17–22,137–143 ] and polyamides, [ 15,23–28,144–149 ] many other polymers: polyurea, [ 29,30,37,38,51,150–164 ] polythiourea, [ 52 ] polyurethane, [ 165,166 ] polyazomethine, [ 167–172 ] poly(3,4‐ethylenedioxy‐thiophene), [ 173–177 ] polyimide–polyamide, [ 141 ] poly(ethylene terephthalate) (PET), [ 50,178–180 ] and others. [ 31,32,39–44,176,181–200 ] In recent years, the organic precursor library has been rapidly expanding. We have collected in Table 1 the organic precursors so far used in ALD/MLD processes, together with the heating temperatures employed for their evaporation in the corresponding process conditions; [ …”

Section: Organic Precursors In Ald/mldmentioning

confidence: 99%

Atomic/Molecular Layer Deposition for Designer's Functional Metal–Organic Materials

Multia

Karppinen

2022

Adv Materials Inter

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organic ligands act as bridges between the metal centers to form infinite 1D, 2D, or 3D structures. These materials are often referred to as coordination polymer (CP) [1] or metal-organic framework (MOF) [2] materials; the latter term is used when the metal-organic material is crystalline and highly porous. [3] The research field of CP-and MOF-type materials has grown tremendously over the last two decades. The structural and chemical diversity of these materials has served as a continuous source of scientific excitement; the same diversity has also triggered huge technological interest as these materials possess enormous potential to be tailored for a wide variety of applications ranging from gas capture, storage, and separation to sensing, catalysis, optics, electronics, and energy storage. [4][5][6][7] Most of the targeted application breakthroughs of metal-organics require that these materials can be produced as highquality thin films and coatings, which can be integrated with the other components in the actual device configuration. The possibility to deposit such thin films in an industry-feasible manner on the substrate types needed, would be a major step forward in the field. [8] Traditionally, solvent-based processes such as liquid-phase epitaxy, Langmuir-Blodgett, layer-by-layer, and electrochemical deposition techniques have been used for metal-organic thin films. [9][10][11] These are, however, incompatible with the requirements set by the possible integration of the materials in microelectronics. This is due to corrosion and contamination risks, and the problems in patterning and precise deposition on high-aspect-ratio features. Hence, it is vital to develop solventfree thin-film deposition routes for the metal-organic material family. In the optimal case, these deposition methods should allow conformal coatings on large-area and high-aspect-ratio substrates.The currently strongly emerging ALD/MLD technique is uniquely suited to address the challenge in a scientifically elegant yet industrially feasible way. This technique is derived from the two parent gas-phase thin-film techniques: ALD for inorganic materials (mostly binary metal oxides, sulfides, and nitrides), [12][13][14] and its counterpart MLD for purely organic thin films (e.g., polyimides and polyamides). [15] In both cases, the attractive film growth characteristics are derived from the unique way of separating the different precursor gas pulses. Currently, ALD is the standard thin-film technology in many Atomic layer deposition (ALD) for high-quality conformal inorganic thin films is one of the cornerstones of modern microelectronics, while molecular layer deposition (MLD) is its less-exploited counterpart for purely organic thin films. Currently, the hybrid of these two techniques, i.e., ALD/MLD, is strongly emerging as a state-of-the-art gas-phase route for designer's metal-organic thin films, e.g., for the next-generation energy technologies. The ALD/MLD literature comprises nearly 300 original journal papers covering most of the alkali...

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Section: Organic Precursors In Ald/mldmentioning

confidence: 99%

Atomic/Molecular Layer Deposition for Designer's Functional Metal–Organic Materials

Multia

Karppinen

2022

Adv Materials Inter

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“…Furthermore, colloidosomes with 3D superstructures can provide protected environments for tissue growth and allow rapid penetration of small macromolecules. The issue of encapsulation of a variety of ingredients such as vitamins, proteins, gas bubbles, flavors, or even living cells is becoming progressively significant in a wide range of applications and technologies . Double emulsion droplets that possess tunable properties impart a range of applications toward biomolecular conjugation, especially, biosensing, drug delivery, and tissue engineering.…”

Section: Applicationsmentioning

confidence: 99%

“…The nanoparticles can arrange themselves in two or three dimensions that results in the synthesis of active materials with high mechanical stability. Efficient encapsulation and controlled release of active ingredients, such as vitamins, proteins, drugs, flavors, gas bubbles, and often living cells in and from these assemblies, is becoming progressively significant for applications in diverse technologies, ranging from functional nutrients to drug release to therapeutic applications, and therefore, the application of this compatible chemistry is of great interest at the interface of materials science, chemistry, biology, and medicine.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly of Nanoparticles in 2D and 3D: Recent Advances and Future Trends

Ghosh

Böker

2019

Macro Chemistry & Physics

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For more than a century, it has been known that emulsions consisting of two immiscible liquids can be rendered from coalescence by means of solid particles, coined as Pickering emulsions. Based on this discovery, novel materials as a result of the formation of 2D and 3D assemblies of nanostructures at liquid–liquid interfaces have been synthesized. These materials have received considerable attention due to several unique attributes of the nanoscale materials within these assemblies and their utilization in a wide arena of niche applications. With the progressive advent of the synthetic strategies of the nanostructures, these assemblies can be engendered to create membranes and capsules with high mechanical strength and desirable porosity and even can be made stimuli‐responsive. The nanostructures, ranging from inorganic particles to proteins to polymeric architectures, possess their stabilizing effects due to excess attachment energies and lead to the maneuvering of exciting structural design, such as colloidosomes and yeastosomes. The ability of the different kind of particles at the nanoscale dimension to self‐assemble at the liquid–liquid interface into ordered superstructures has substantial potential toward the design of exotic electronic, catalytic, optical, magnetic, and biomimetic materials.

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“…Coating micron-sized protein particles with a polyester film by an MLD scheme resulted in serious agglomeration (Vasudevan et al, 2015) that compromised the fluidization of the powder. Implementing vibration and a microjet, and using long intermediate purging pulses with high flow-rates of N2, helped reestablish fluidization in the system.…”

Section: Agglomeration During Ald Processing Of Solidsmentioning

confidence: 99%

Advances in scalable gas-phase manufacturing and processing of nanostructured solids: A review

et al. 2017

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Although the gas-phase production of nanostructured solids has already been carried out in industry for decades, only in recent years has research interest in this topic begun to increase. Nevertheless, despite the remarkable scientific progress made recently, many long-established processes are still used in industry.Scientific advancements can potentially lead to the improvement of existing industrial processes, but also to the development of completely new routes. This paper aims to review state-of-the-art synthesis and processing technologies, as well as the recent developments academic research. Flame reactors that produce inorganic nanoparticles on industrial-and lab-scales are described, alongside a detailed overview of the different systems used for the production of carbon nanotubes and graphene. We discuss the problems of agglomeration and mixing of nanoparticles, which are strongly related to synthesis and processing. Finally, we focus on two promising processing techniques, namely nanoparticle fluidization and atomic layer deposition.

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Controlled release from protein particles encapsulated by molecular layer deposition

Cited by 16 publications

References 28 publications

Atomic/Molecular Layer Deposition for Designer's Functional Metal–Organic Materials

Atomic/Molecular Layer Deposition for Designer's Functional Metal–Organic Materials

Self‐Assembly of Nanoparticles in 2D and 3D: Recent Advances and Future Trends

Advances in scalable gas-phase manufacturing and processing of nanostructured solids: A review

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