Controlled Release Formulation of Indomethacin Prepared With Bee Glue Extracts

Honary, Soheila; Ebrahimi, Parvaneh; Naghibi, F; Chaigani, M

doi:10.4314/tjpr.v10i5.2

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Propolis powder was passed through a sieve with an aperture of 850 μm as this is the ideal measure of particle size. 25 The propolis powder was transferred into the semi-automated encapsulating machine (Njp200c, China) to punch into size one capsules. Then, the capsules were cleaned and polished using a gauze or cloth.…”

Section: Capsule Fillingmentioning

confidence: 99%

Encapsulation of Freeze-dried Propolis Powder: Study of in vitro Disintegration and Dissolution

Zainal¹,

Enidran²,

Ganesan³

2021

IJPER

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Propolis is a resinous material collected by bees from various plant sources. Propolis has been used since ancient times for medicinal purposes. In this study, the propolis extracts were dried using a freeze-drying technique to preserve its medicinal properties. The effect of different freezing temperatures on the yield and propolis powder flow ability characteristics was evaluated. The potential of propolis powder to be encapsulated in hard gelatin capsules and hard hydroxypropyl methylcellulose (HPMC) capsules were investigated. The mass uniformity, in vitro disintegration and dissolution performance of the propolis powder in hard gelatine capsules and hard HPMC capsules were determined after encapsulation. The amount of propolis powder produced after freeze-drying decreased with decreasing of freezing temperature from -50°C to -80°C. Propolis powder obtained at -80°C of freezing temperature showed excellent flow ability characteristics. The average mass of propolis powder in hard gelatine capsules and the propolis powder in hard HPMC capsules was 0.5578 ± 0.019g and 0.5559 ± 0.020 g, respectively. In vitro disintegration test showed that the propolis powder that was loaded into the hard gelatine capsules disintegrated faster than the propolis powder loaded into the hard HPMC capsules, which were 1.7 to 7.8 min and 3.7 to 8.4 min in all four media solutions. Among the dissolution media tested, 1 % SLS in water showed the highest release of flavonoid. The studies of an encapsulated form of propolis powder are recommended prior to the release of a dietary supplement or clinical trial investigational product to ensure its efficacy.

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Section: Capsule Fillingmentioning

confidence: 99%

Encapsulation of Freeze-dried Propolis Powder: Study of in vitro Disintegration and Dissolution

Zainal¹,

Enidran²,

Ganesan³

2021

IJPER

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“…When they provide sustained drug release in the gastrointestinal track, risk of systemic side effects of drugs can be minimized by administering lower daily dose to the patients. Matrix tablets also relatively easy and cost-effective to produce with high reproducibility, unlike conventional tablets for rapid drug release [5,6].…”

Section: Introductionmentioning

confidence: 99%

Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

Yener¹,

Ayçiçek²,

Üner³

et al. 2017

Trop. J. Pharm Res

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Formulation and Evaluation of Drug Release Profile of Hydrophilic Polymer Based Indomethacin Prolong Release Matrix Tablets

Gaja¹,

Beyatricks²,

Monisha³

2021

ijsr

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An oral modied release dosage forms have always been more effective therapeutic alternative to conventional dosage forms. The present invention is directed to a modied release pharmaceutical composition of indomethacin by using hydrophilic release retardant polymers like HPMC K15M, Na CMC alone or in combination. Matrix embedded prolong release tablet formulations of Indomethacin were prepared by wet granulation technique and evaluated for tablet properties such as the thickness, hardness, friability, weight variation, drug content, drug release kinetics and in vitro release studies. The inuence of drug polymer ratio on drug release was studied by dissolution test. The FTIR studies showed no interactions among drug and polymers. The tablets formulation (F7 and F8) containing combined polymers of HPMC K15M and Na CMC resulted in slower drug release rate form the matrix. So, it can be concluded that Indomethacin prolong release tablets using HPMC K15M and Na CMC as the retardant has successfully extended the release of indomethacin from its formulations. The mixing of two cellulose polymers, ionic and non-ionic, for the formulation of hydrophilic matrices, resulted in a valuable decrease in drug release rate. All the formulations showed KorsmeyerPeppa’s model as a best t.

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Controlled Release Formulation of Indomethacin Prepared With Bee Glue Extracts

Abstract: Purpose: To prepare and evaluate new sustained release formulations of indomethacin based on extracts of propolis (bee glue)

Cited by 3 publications

References 16 publications

Encapsulation of Freeze-dried Propolis Powder: Study of in vitro Disintegration and Dissolution

Encapsulation of Freeze-dried Propolis Powder: Study of in vitro Disintegration and Dissolution

Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

Formulation and Evaluation of Drug Release Profile of Hydrophilic Polymer Based Indomethacin Prolong Release Matrix Tablets

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