Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

Yener, Gülgün; Ayçiçek, Evin; Üner, Melike; Altuntaş, Ebru

doi:10.4314/tjpr.v15i12.3

Cited by 1 publication

(3 citation statements)

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“…Hausner ratio = (Tapped density) / (Bulk density) Physical Characterization of Tablets: [19][20][21] Drug Content: The matrix tablets were triturated and powdered. An amount of powder equivalent to 40 mg propranolol hydrochloride was taken for the drug content analysis.…”

Section: Measures Of Powder Compressibilitymentioning

confidence: 99%

“…After 20 min tablets were removed, and it was dedusted. The final weights of the tablets were recorded and the friability in percentage (F) was calculated using the following equation 20,21 .…”

Section: Friabilitymentioning

confidence: 99%

“…The disintegration test was carried out by the use of USP-type apparatus model number ED-2AL. In the disintegration apparatus, 6 tablets in each station were placed, and the test was carried out for the time taken to completely disintegrate; the tablets were recorded 20,21 .…”

Section: Friabilitymentioning

confidence: 99%

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2021

IJPSR

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Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix tablets of anti-hypertensive drug, Propranolol HCL were prepared and evaluated. The HPMC was used as a rate retarding polymer, whereas Talc was used as filler, and magnesium stearate was used as a lubricant. The present study results point out that the rate of propranolol HCL release from HPMC matrices is mainly controlled by the drug: HPMC ratio. When the concentration of HPMC was enhanced, the release of the drug from the matrix tablet was retarded. The prepared hydrogel matrix tablets were evaluated for various parameters like Angle of Repose, Bulk Density, Tapped Density, Carr's Index, hardness, friability, uniformity of weight, uniformity of drug content, and disintegration studies. The drug-polymer interaction studies were carried out by FTIR studies where it showed that there was no significant interaction. The in-vitro drug release was carried out for all the formulations, and formulation F1 showed about 96% drug release at 12 h. It was concluded that the hydrogel matrix tablet of Propranolol HCL by using HPMC can be prepared to get the desired release of the drug up to 12 h.

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Section: Measures Of Powder Compressibilitymentioning

confidence: 99%

Section: Friabilitymentioning

confidence: 99%