Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite

Ho, Mei-Ling; Fu, Yaw-Syan; Wang, Gwo Jaw; Chen, Hui Ting; Chang, Jyh-Jong; Tsai, Tsung Hsien; Wang, Chih Kuang

doi:10.1016/j.jconrel.2008.02.012

Cited by 91 publications

(47 citation statements)

References 23 publications

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“…The binding capacity of NPs to HAp was evaluated using a method similar to that described in some previous reports. 26,27 In brief, NPs loaded with the hydrophobic fluorescent dye ODA-FITC were used at a dilution of 4 mL (0. …”

Section: Alizarin Red S Assaymentioning

confidence: 99%

Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

Wang¹,

Liu²,

Tao³

et al. 2015

IJN

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Purpose Nanoparticles (NPs) that target bone tissue were developed using poly(lactic-co-glycolic acid) (PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties. These NPs are expected to enable the transport of drugs, such as simvastatin (SIM), for the treatment of osteoporosis. Methods The molecular structures of TC–PLGA were validated by 1 H-NMR, and the SIM-loaded NPs were prepared using the solvent emulsification method. The surface properties, cytotoxicity, cellular uptake, cell mineralization, bone targeting potential, and animal pharmacodynamics of the TC–PLGA NPs were evaluated and compared to those of PLGA NPs. Results It was confirmed that the average particle size of the NPs was approximately 220 nm. In phosphate-buffered saline (PBS, pH 7.4), the SIM-loaded NPs exhibited a cumulative release of up to 80% within 72 hours. An in vitro cell evaluation indicated that the NPs had an excellent cellular uptake capacity and showed great biocompatibility with MC3T3-E1 cells, thereby reducing the cytotoxic effects of SIM. The cell mineralization assay showed that the SIM-loaded NPs induced osteogenic differentiation and mineralized nodule formation in MC3T3-E1 cells, thereby achieving the same effect as SIM. Preliminary findings from in vitro and in vivo bone affinity assays indicated that the TC–PLGA NPs may display increased bone-targeting efficiency compared to PLGA NPs lacking a TC moiety. The use of SIM-loaded TC–PLGA NPs in treating osteoporosis was tested through animal pharmacodynamics analyses performed in ovariectomized rats, and the results suggested that the SIM-loaded TC–PLGA NPs can improve the curative effects of SIM on the recovery of bone mineral density compared to either SIM-loaded PLGA NPs or SIM alone. Conclusion Bone-targeting NPs, which were based on the conjugation of TC to PLGA copolymers, have the ability to target bone. These NPs may be developed as a delivery system for hydrophobic drugs, and they are expected to improve the curative effects of drugs, reduce the administered drug doses, and reduce side effects in other organs.

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Section: Alizarin Red S Assaymentioning

confidence: 99%

Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

Wang¹,

Liu²,

Tao³

et al. 2015

IJN

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“…In addition to the simple emulsion-solvent evaporation process, composites can also be prepared by multiple (w/o/w) emulsion-solvent evaporation (55). Hap powder and drug (BSA) were dispersed in phosphate-buffered saline (PBS) buffer to form the first water phase.…”

Section: Emulsion-solvent Evaporation Methodsmentioning

confidence: 99%

Organic–Inorganic Composites for Bone Drug Delivery

Soundrapandian

Datta

2009

AAPS PharmSciTech

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Abstract. This review paper attempts to provide an overview in the fabrication and application of organic-inorganic based composites in the field of local drug delivery for bone. The concept of local drug delivery exists for a few decades. However, local drug delivery in bone and specially application of composites for delivery of drugs to bone is an area for potential research interest in the recent time. The advantages attained by an organic-inorganic composite when compared to its individual components include their ability to release drug, adopting to the natural environment and supporting local area until complete bone regeneration, which make them carriers of interest for local drug delivery for bone.

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“…This would provide a scaffold allowing for ingrowth of bone and also blood vessels, while recruiting MSCs to the area to form bone [24]. Various scaffolds composed of PLGA, collagen hydroxyapatite, and β-TCP have been used to Bcarry^BMP-2 and release it over a sustained period of time [22,24,31,32,38,39]. In a study by Wang and colleagues, an improvement in healing of necrotic segments of bone with controlled release of BMP was noted [24].…”

Section: Animal Studies Investigating Bone Morphogenetic Proteins Formentioning

confidence: 99%

Osteonecrosis of the femoral head: treatment with ancillary growth factors

Houdek

Wyles

Sierra

2015

Curr Rev Musculoskelet Med

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Osteonecrosis (ON) of the femoral head, also known as avascular necrosis (AVN) of the femoral head, is a progressive disease that predominantly affects younger patients. During early stage of ON, decompression of the femoral head has been commonly used to improve pain. The decompression has been augmented with nonvascularized or vascularized bone grafts, mesenchymal stems cells, and growth factors. The use of adjuvant growth factors to supplement the core decompression has mainly been limited to animal models in an attempt to regenerate the necrotic lesion of ON. Factors utilized include bone morphogenetic proteins, vascular endothelial growth factors, hepatocyte growth factors, fibroblast growth factors, granulocyte colonystimulating factors, and stem cells factors. In animal models, the use of these factors has been shown to increase bone formation and angiogenesis. Although promising, the use of these growth factors and cell-based therapies clinically remains limited.

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Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite

Cited by 91 publications

References 23 publications

Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

Organic–Inorganic Composites for Bone Drug Delivery

Osteonecrosis of the femoral head: treatment with ancillary growth factors

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