Controlled Production of Emulsions Using a Crossflow Membrane

Williams, Richard A; Peng, S. J.; Wheeler, Damon A.; Morley, N. C.; Taylor, D. R.; Whalley, Margaret; Houldsworth, D. W.

doi:10.1205/026387698525702

Cited by 147 publications

(99 citation statements)

References 6 publications

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“…Several single-drop technologies have been developed for generating uniform droplets, such as injection of liquid through a capillary into another co-flowing immiscible fluid [3,4], penetration of dispersed phase through microfabricated parallel silicon channels [5] or interconnected channel network in microfluidic devices [6,7], and injection of dispersed phase through microporous membranes of different nature (glass, ceramic, metallic, polymeric) [8][9][10][11][12][13][14]. Production of various particulate products, such as microspheres and microcapsules, using membrane emulsification routes was recently reviewed by Vladisavljević and Williams [15].…”

Section: Introductionmentioning

confidence: 99%

“…The requirement for circulation of the continuous phase along the membrane surface can thus be totally avoided. Compared with cross membrane emulsification methods [2,14] this can be particularly advantageous to the production of coarse emulsions and fragile structured products, in which the droplets and/or particles are subject to breakage during the pump circulation. The dispersed phase passes radially through the porous membrane wall and forms droplets moving into the continuous phase.…”

Section: Introductionmentioning

confidence: 99%

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Manufacture of large uniform droplets using rotating membrane emulsification

Vladisavljević

Williams

2006

Journal of Colloid and Interface Science

119

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A new rotating membrane emulsification system using a stainless steel membrane with 100 µm laser drilled pores was used to produce oil/water emulsions consisting of 2 wt. % Tween 20 as emulsifier, paraffin wax as dispersed oil phase and 0.01-0.25 wt. % Carbomer (Carbopol ETD 2050) as stabilizer. The membrane tube, 1 cm in diameter, was rotated inside a stationary glass cylinder, diameter of 3 cm, at a constant speed in the range 50-1500 rpm. The oil phase was introduced inside the membrane tube and permeated through the porous wall moving radially into the continuous phase in the form of individual droplets. Increasing the membrane rotational speed increased the wall shear stress which resulted in a smaller average droplet diameter being produced. For a constant rotational speed, the average droplet diameter increased as the stabilizer content in the continuous phase was lowered. The optimal conditions for producing uniform emulsion droplets were a Carbomer content of 0.1-0.25 wt. % and a membrane rotational speed of 350 rpm, under which the average droplet diameter was 105-107 µm and very narrow coefficients of variation of 4.8-4.9 %. A model describing the operation is described and it is concluded that the methodology holds potential as a manufacturing protocol for both coarse and fine droplets and capsules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Manufacture of large uniform droplets using rotating membrane emulsification

Vladisavljević

Williams

2006

Journal of Colloid and Interface Science

119

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“…[4] and was initially investigated exclusively using a Shirasu porous glass (SPG) membrane developed by the same authors [5]. In the meantime, this emulsification technology has been attracting an increasing attention all over the world and as a result, other porous membranes have been also investigated as emulsifying mediums, such as ceramic -Al 2 O 3 and Zr 2 O 3 membranes [6][7][8], silica membranes [9], perforated stainless steel plates [10], polymeric membranes made of different materials such as polypropylene [11], polytetrafluoroethylene [12], and polycarbonate [13], microengineered silicon nitride microsieves [14], etc. However, there are few investigations [6,15] with the objective of comparing the characteristics of ME process using porous membranes of different structures.…”

Section: Introductionmentioning

confidence: 99%

Production of O/W emulsions using SPG membranes, ceramic α-aluminium oxide membranes, microfluidizer and a silicon microchannel plate—a comparative study

Vladisavljević

Lambrich

Nakajima

et al. 2004

Colloids and Surfaces A: Physicochemical and Engineering Aspect

113

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“…The mean droplet/channel size ratio of 2.63 was smaller than the mean droplet/pore size ratio of 3.0 found in droplet formation from Shirasu Porous Glass (SPG) membrane within the same range of SDS concentration [32], but similar to the mean droplet/pore size ratios in membrane emulsification using asymmetric aluminium oxide membranes [33,34]. The d 3,2 value of 26.3 m is significantly smaller than the average droplet diameter of 39.1 m reported in straight-through MC emulsification for the system containing 1 wt% SDS and soybean oil using a symmetric MC plate with 10  50 m channels [25].…”

Section: Effect Of Emulsifier Content In Continuous Aqueous Phasementioning

confidence: 52%

Generation of highly uniform droplets using asymmetric microchannels fabricated on a single crystal silicon plate: Effect of emulsifier and oil types

2008

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Uniform droplets of soybean oil, MCT (medium-chain fatty acid triglyceride) oil and ntetradecane with a mean diameter of 26-29 m have been generated using a silicon 24  24 mm microchip consisting of 23,489 asymmetric microchannels fabricated by photolitography and deep reactive ion etching. Each microchannel consisted of a circular 10-m diameter straight hole with a length of 70 m and a 50  10 m rectangular microslot with a depth of 30 m. At the constant oil flux of 10 Lm -2 h -1 , the percent of active channels increased with increasing the oil viscosity and ranged from 4 % for n-tetradecane to 48 % for soybean oil. The size distribution span for SDS (sodium sodium dodecyl sulphate)-and Tween 20 (polyoxyethylene (20) sorbitan monolaurate)-stabilised soybean and MCT oil droplets was 0.21-022. The ability of asymmetric microchannels to generate monodisperse soybean oil droplets at the very low SDS concentration of 0.01 wt% has been demonstrated. At the SDS concentration below the CMC, the generated droplets tend to attach to the plate surface, whereas at the higher SDS concentration they detach from the plate as soon as they are formed. The agreement between the experimental and CFD (Computational Fluid Dynamics) simulation results was excellent for soybean oil and the poorest for n-tetradecane.

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Controlled Production of Emulsions Using a Crossflow Membrane

Cited by 147 publications

References 6 publications

Manufacture of large uniform droplets using rotating membrane emulsification

Manufacture of large uniform droplets using rotating membrane emulsification

Production of O/W emulsions using SPG membranes, ceramic α-aluminium oxide membranes, microfluidizer and a silicon microchannel plate—a comparative study

Generation of highly uniform droplets using asymmetric microchannels fabricated on a single crystal silicon plate: Effect of emulsifier and oil types

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