Controlled manipulation of molecular samples with the nanoManipulator

Guthold, Martin; Falvo, M. R.; Matthews, William G.; Paulson, Scott; Washburn, S.; Erie, Dorothy A.; Superfine, R.; Brooks, Frederick P.; Taylor, Ii. R.M.

doi:10.1109/3516.847092

Cited by 205 publications

(73 citation statements)

References 39 publications

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“…Approximately 80% of nM use is in replay mode where scientists move forward and backward through the data, stopping at critical points to perform visualization and analysis. Details regarding the nM and its uses are described in (Finch, Chi, Taylor II, Falvo, et al, 1995;Taylor II & Superfine, 1999;Guthold, 2000;Guthold, Matthews & Negishi, 1999).…”

Section: Evaluation Context: the Nanomanipulator Collaboratorymentioning

confidence: 99%

“…During each scientific research lab, study participants were asked to work together, using the collaboratory system in replay mode to manipulate and analyze data recorded previously during an experiment conducted by a physicist (Guthold, 2000). As discussed above, the pre-recorded stream file contained an exact and complete record of all data collected from an AFM when the experiment was originally performed.…”

Section: Experiments Designmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a Scientific Collaboratory System: Investigating Utility before Deployment

Sonnenwald¹,

Whitton²,

Maglaughlin³

2008

Scientific Collaboration on the Internet

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Section: Evaluation Context: the Nanomanipulator Collaboratorymentioning

confidence: 99%

Section: Experiments Designmentioning

confidence: 99%

Evaluation of a Scientific Collaboratory System: Investigating Utility before Deployment

Sonnenwald¹,

Whitton²,

Maglaughlin³

2008

Scientific Collaboration on the Internet

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“…7 The NANOMANIPULATOR provides control over the motion of the AFM tip in the x, y, and z directions. For these experiments, the AFM tip was pushed down normally on the surface with a small, constant normal force and moved laterally in a user-defined path.…”

Section: Glass Fiber Bending Experimentsmentioning

confidence: 99%

“…For example, the nanoscopic, frictional forces between functionalized tips and surfaces have been determined 2,6 and the mechanical properties of viruses, DNA, carbon nanotubes, and fibrin fibers have been measured. [7][8][9] In all AFM force measurements, the AFM cantilever is used to apply forces to the sample under investigation. To extract reliable, quantitative values for material properties from these measurements, the applied forces need to be accurately known, which, in turn, critically depends on reliable and universally applicable force calibration methods for AFM instruments.…”

Section: Introductionmentioning

confidence: 99%

Easy and direct method for calibrating atomic force microscopy lateral force measurements

Liu

Bonin

Guthold

2007

Review of Scientific Instruments

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We have designed and tested a new, inexpensive, easy-to-make and easy-to-use calibration standard for atomic force microscopy (AFM) lateral force measurements. This new standard simply consists of a small glass fiber of known dimensions and Young's modulus, which is fixed at one end to a substrate and which can be bent laterally with the AFM tip at the other end. This standard has equal or less error than the commonly used method of using beam mechanics to determine a cantilever's lateral force constant. It is transferable, thus providing a universal tool for comparing the calibrations of different instruments. It does not require knowledge of the cantilever dimensions and composition or its tip height. This standard also allows direct conversion of the photodiode signal to force and, thus, circumvents the requirement for a sensor response (sensitivity) measurement.

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“…In the widely applied AFM experiments [2][3][4][5][6][7][8][9][10][11][12][13] , a large amount of frontier progresses have been achieved about nano manipulation. However, the theoretical analysis for such system is mainly focused on the static force analysis within a Newton-mechanical framework [4][5][6][7][8][9][10][11][12][13] that describes the macroscopic system. Recent experiments show that the force analysis in the nano scale is not the same as that at the macroscopic scale.…”

Section: Introductionmentioning

confidence: 99%

Suppressing nano-scale stick-slip motion by feedback

Zhang

Miao

et al. 2012

Journal of Applied Physics

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When a micro cantilever with a nano-scale tip is manipulated on a substrate with atomic-scale roughness, the periodic lateral frictional force and stochastic fluctuations may induce stick-slip motion of the cantilever tip, which greatly decreases the precision of the nano manipulation. This unwanted motion cannot be reduced by open-loop control especially when there exist parameter uncertainties in the system model, and thus needs to introduce feedback control. However, real-time feedback cannot be realized by the existing virtual reality virtual feedback techniques based on the position sensing capacity of the atomic force microscopy (AFM). To solve this problem, we propose a new method to design real-time feedback control based on the force sensing approach to compensate for the disturbances and thus reduce the stick-slip motion of the cantilever tip. Theoretical analysis and numerical simulations show that the controlled motion of the cantilever tip tracks the desired trajectory with much higher precision. Further investigation shows that our proposal is robust under various parameter uncertainties. Our study opens up new perspectives of real-time nano manipulation.

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Controlled manipulation of molecular samples with the nanoManipulator

Cited by 205 publications

References 39 publications

Evaluation of a Scientific Collaboratory System: Investigating Utility before Deployment

Evaluation of a Scientific Collaboratory System: Investigating Utility before Deployment

Easy and direct method for calibrating atomic force microscopy lateral force measurements

Suppressing nano-scale stick-slip motion by feedback

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