Controlled Hypotension With Arfonad

The Effect of Anaesthesia, Hypotension, and Epidural Analgesia on Blood Loss in Surgery for Pelvic Floor Repair

“…A striking feature of this investigation has been the wide range of results in all groups, despite the fact that a classical, common surgical procedure, performed through tissues which were essentially normal, was chosen for study. The observation that good operating conditions do not always accompany a satisfactory level of induced hypotension was made in the early days of the technique (Scurr and Wyman, 1954) and has since been made repeatedly even when tachycardia has been controlled (Hellewell and Potts, 1966), and is confirmed in the present investigation, for it proved impossible in any one case to predict reliably that a relatively dry operating field would be obtained. Equally, it was impossible to attribute, with any certainty, a dry operating field to a particular anaesthetic.…”

“…The early practice involved production of a high spinal anaesthetic (Griffiths and Gillies, 1948;Greene, 1952). This technique was modified with the introduction of ganglion blocking drugs (Enderby, 1950;Scurr and Wyman, 1954). More recently, the hypotensive effects of halothane have been used (Gusterson, 1959;Eckenhoft, 1965).…”

Antihypertensive Agents

“…Synthesis [25] Pharmacology [26] Therapy [27] Pentolium tartrate (VIII) Synthesis [24] Pharmacology [25] Therapy [28] Trimethaphan (IX) MARXER and MIESCHER [13] modified the structure of the interquarternary linking chain in an effort to achieve optimal ganglionic blocking effects. Compounds with five-or six-membered chains separating symmetricallysubstituted cationic centers [14], with the replacement of one methylene group by a hetero atom, were minimally effective in achieving ganglionic blockade.…”

The Use of Hypotension in Anaesthesia for Ear, Nose and Throat Operations

“…Of the papers published so far, few seem to have mentioned their wide field of application in these operations. Scurr and Wyman (1954) record the use of Arfonad in 20 operations upon the mouth, nose and throat, but do not mention the particular advantages obtained. Stirling (1955) described 20 fenestrations using hexamethonium bromide with excellent results.…”