Controlled Encapsulation of Hydrophobic Liquids in Hydrophilic Polymer Nanofibers by Co‐electrospinning

Diaz, Juan E.; Barrero, Antonio; Márquez, Manuel; Loscertales, Ignacio G.

doi:10.1002/adfm.200600204

Cited by 157 publications

(118 citation statements)

References 22 publications

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“…Polymer fibres have a vast scope of applications, including biofuel cell, electronics, filtration and mechanical composite material [1][2][3][4][5][6][7][8][9]. A uniform bead free structure of fibre is usually used, for example in high efficiency filtering membranes, and protective clothing due to its features of large specific surface area, narrow apertures and good mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Beads, beaded-fibres and fibres: Tailoring the morphology of poly(caprolactone) using pressurised gyration

Hong

Edirisinghe

Muthusubramanian

2016

Materials Science and Engineering: C

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This work focuses on forming bead on string poly(caprolactone) (PCL) by using gyration under pressure. The fibre morphology of bead on string is an interesting feature that falls between bead-free fibres and droplets, and it could be effectively controlled by the rheological properties of spinning dopes and the major processing parameters of the pressurised gyration system which are working pressure and rotating speed. Bead products were not always spherical in shape and tender to be more elliptical, therefore both their width and length were measured. The average bead width and length produced spanned a range 145 -660µm and 140 -1060µm, respectively. The average distance between two adjacent beads (i.e. inter-bead distance) and the bead size (width and length) are shown to be a function of processing parameters and polymer concentration. An interesting morphology i.e. beads with short fibre was observed when using a high polymer concentration. Bead on string structure agglomeration was promoted by a low polymer concentration. Formation of droplets or agglomerated bead on string is promoted below 5wt% polymer concentration, and beads with short fibre were present in the microstructure beyond a polymer concentration of 20 wt%.

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Section: Introductionmentioning

confidence: 99%

Beads, beaded-fibres and fibres: Tailoring the morphology of poly(caprolactone) using pressurised gyration

Hong

Edirisinghe

Muthusubramanian

2016

Materials Science and Engineering: C

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“…The sheath solution is critical, and the sheath polymer-solvent system selected should be electrospinnable by itself to facilitate formation of a core-sheath structure in the nanofibers. [40][41][42] Thus, although the core solution consisting of 10% (w/v) PVP and 2% (w/v) acyclovir in a mixed solvent of DMAc:ethanol (4:6, v:v) was nonelectrospinnable, the electrospinnable sheath fluid consisting of 10% (w/v) PVP, 0.5% (w/v) SDS, and 0.2% (w/v) sucralose in a mixed solvent of water:ethanol (2:8, v:v) was able to ensure a smooth coaxial electrospinning process and formation of core-sheath nanofibers.…”

Section: Coaxial Electrospinningmentioning

confidence: 99%

Solid dispersions in the form of electrospun core-sheath nanofibers

Yu¹,

Zhu²,

Branford-White³

et al. 2011

IJN

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Background:The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions. Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filamentforming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir. Results: The core-sheath nanofibers had an average diameter of 410 ± 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles. Conclusion: The study reported here provides an example of the systematic design, preparation, characterization, and application of a novel type of solid dispersion consisting of multiple components and structural characteristics.

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“…It also allows encapsulating of core liquid and the production of tubes [12,13]. The sol-gel technique has been widely studied for the preparation of different forms including monoliths, powders, coatings, and fibers [14,15].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of silica sub-microtubes mats with platinum nanoparticles for NO catalytic reduction

Ruiz-Rosas¹,

Rosas²,

Loscertales³

et al. 2014

Applied Catalysis B: Environmental

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Silica sub-microtubes loaded with platinum nanoparticles have been prepared in flexible non-woven mats using co-axial electrosppining technique. A partially gelated sol made from tetraethyl orthosilicate was used as the silica precursor, and oil was used as the sacrificial template for the hollow channel generation. Platinum has been supported on the wall of the tubes just adding the metallic precursor to the sol-gel, thus obtaining the supported catalyst by one-pot method. The silica tubes have a high aspect ratio with external/internal diameters of 400/200 nm and well-dispersed platinum nanoparticles of around 2 nm. This catalyst showed a high NO conversion with very high selectivity to N 2 at mild conditions in the presence of excess oxygen when using C 3 H 6 as reducing agent. This relevant result reveals the potential of this technique to produce nanostructured catalysts onto easy to handle conformations.Keywords: coaxial electrospinning, silica nanotubes, platinum nanoparticles, NOx SCR. Graphical AbstractHighlights  Non-woven mats of platinum-loaded silica nanotubes were obtained by co-axial electrospinning in one-pot procedure. By this technique, high dispersed Pt nanoparticles can be easily deposited on the walls of the silica nanotubes. Pt-loaded silica nanotube non-woven mats show high activity for low temperature NOx SCR with propylene in the presence of excess oxygen and outstanding N 2 selectivity, at the studied operation conditions.

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Controlled Encapsulation of Hydrophobic Liquids in Hydrophilic Polymer Nanofibers by Co‐electrospinning

Cited by 157 publications

References 22 publications

Beads, beaded-fibres and fibres: Tailoring the morphology of poly(caprolactone) using pressurised gyration

Beads, beaded-fibres and fibres: Tailoring the morphology of poly(caprolactone) using pressurised gyration

Solid dispersions in the form of electrospun core-sheath nanofibers

Electrospinning of silica sub-microtubes mats with platinum nanoparticles for NO catalytic reduction

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