Controlled drug release of levofloxacin from poly (acrylamide) hydrogel

Abstract

Hydrogels are 3D polymer networks capable to absorb and release water or biological fluids. They are stimuli-responsive materials, which can show rapid volume changes with response to small changes in environmental parameters such as ionic strength, pH, and temperature. In this work, we performed a synthesis of Poly(acrylamide) hydrogel and tested for controlled release of levofloxacin hemihydrate as a model drug. We used sodium metabisulfite and potassium persulphate as free radical initiators to prepare hydrogel with methylenebisacrylamide as a crosslinker. Characterization of hydrogel was performed by TGA, SEM, and FT-IR. Swelling study and drug release were performed at pH 1.2 and 7.4 solutions, identical to the gastrointestinal fluid at 37°C (human body temperature) to examine possible site-specific drug delivery. UV-Visible spectrophotometer was used to measure the concentration of drug release. Results exhibited the pH and temperature-dependent drug release. The amount of drug release was found to be 17% and 99% in acidic and alkaline pH of 1.2 and 7.4, respectively, after 6 hours.

Synthesis of Poly(methacrylamide‐co‐methacrylic acid) Nanogels: Effect of Synthesis Parameters on the Nanosize, Characterization and Stimuli‐Sensitive Characteristics

“…In the study of Madhusudana et al [41] . poly(acrylamide‐co‐acrylic acid) based hydrogels were synthesized and they found that a higher weight loss was occurred at 384 °C which was attributed to destruction of cross‐linked chain [41] …”

“…[40] In the study of Madhusudana et al [41] poly(acrylamide-coacrylic acid) based hydrogels were synthesized and they found that a higher weight loss was occurred at 384 °C which was attributed to destruction of cross-linked chain. [41] In our study, the weight loss between 150-250 °C can be assigned to MAAc chain degradation and the highest weight loss occurred in the range of 250-450 °C indicating the main decomposition step. The contents of the surfactant and crosslinker did not significantly affect the thermal profile and weight loss (%).…”

“…They observed weight losses between 168-208 °C and 200-450 °C due to degradation of CÀ OÀ C bonding which belong to methacrylic acid and acrylamide bond decomposition, respectively. [40] In the study of Madhusudana et al [41] poly(acrylamide-coacrylic acid) based hydrogels were synthesized and they found that a higher weight loss was occurred at 384 °C which was attributed to destruction of cross-linked chain. [41] In our study, the weight loss between 150-250 °C can be assigned to MAAc chain degradation and the highest weight loss occurred in the range of 250-450 °C indicating the main decomposition step.…”