Controlled drug release from Gelucire-based matrix pellets: Experiment and theory

Siepmann, Florence; Muschert, Susanne; Flament, Marie‐Pierre; Leterme, P.; Gayot, A.; Siepmann, Juergen

doi:10.1016/j.ijpharm.2006.03.006

Cited by 43 publications

(18 citation statements)

References 20 publications

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“…The underlying physical process of drug release from the biodegradable polymer is complex and involves Fickian diffusion through the polymer matrix, diffusion through pores in the matrix, relaxation of the matrix, and drug liberation via polymer erosion [49][50][51][52]. The diffusion of drug from the surface of the biodegradable polymer surface is dictated by the excluded volume, hydrodynamic interaction and specific interactions, including coulombic interaction and hydrogen bonding.…”

Section: Drug Release Responsementioning

confidence: 99%

On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

et al. 2008

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Section: Drug Release Responsementioning

confidence: 99%

On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

et al. 2008

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“…It may, however, be noted that the drug release behavior from a biodegradable polymer carrier is complex and involves a number of factors, including Fickian diffusion through the polymer matrix, pores in the matrix and the interface boundary layer, relaxation of the matrix and deliverance of the encapsulated substance due to hydrolytic or enzymatic degradation of the matrix [33][34][35][36][37]. For instance, recent research suggested that the diffusion of methyl red was retarded substantially more in a toluene solution of poly(vinyl acetate) than in polystyrene [38].…”

Section: Drug Release Behaviormentioning

confidence: 99%

On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: Functionalization, conjugation and drug release kinetics

et al. 2007

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“…Examples of sustained-release matrix pellet formulations are listed in Table IV. Several hydrophobic materials have been reported to achieve sustained-release matrix pellets. Waxes such as Gelucires (Montousse et al, 1999;Siepmann et al, 2006) and Compritol 888 ATO (Chi et al, 2010) were used for theophylline and ambroxol sustained-release matrix pellets. Hydrophobic polymer such as ethylcellulose (Chi et al, 2010;Kojima and Nakagami, 2002;Mayo-Pedrosa et al, 2007) and enteric-coated polymer such as Eudragit ® L 100-55 (Mehta et al, 2000(Mehta et al, , 2001 were also utilized for sustained-release matrix pellets.…”

Section: Coated Pellets For Sustained Drug Deliverymentioning

confidence: 99%

Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process

Rhee¹,

Lee²,

Lee³

et al. 2010

Journal of Pharmaceutical Investigation

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− Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.Key words − Pellets, Multiparticulates, Modified-release, Pelletization, Solubilization Pelletization process is an agglomeration process that results in agglomerates of a narrow size distribution in the range of 0.5-1.5 mm with a low intra-agglomerate porosity (about 10%) and the higher density compared to the granules. Pellets are produced by pelletization process and these agglomerates have the relatively spherical shape, low friability and free flowing properties, which facilitate the handling of pellets in the manufacturing process. Pelletization process can prevent the segregation of co-agglomerated components, resulting in an improvement of the content uniformity. Pelletization process can also avoid the dust formation resulting in an improvement of the process safety, as fine powders can cause dust explosions and respiratory health problems. Pellets are widely used in multiparticulate systems and multiparticulate systems have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. The low inter-and intra-subject variability can be achieved by multiparticulate systems because multiparticulates can pass through the pylorus immediately after administration. Moreover, less effect of food on drug absorption and rather uniform gastric emptying time than single-unit dosage systems can be attainable in multiparticulate systems. Safety concerns due to dose dumping of drugs, which have narrow therapeutic index, is minimized in multiparticulate systems, and more foreseeable drug delivery in sustained release formulation is possible because the total drug dose is divided over many units, not in a single-unit system. The small size of multiparticulates also enables them to be well dispersed along the gastrointestinal (GI) tract, enhancing drug absorption and reducing the irritant effect that single-unit systems may cause to the mucosal lining, especially if remained for an extended time at a specific site. The spherical pellets can be coated with rate-controlling polymers or compressed into tablets to achieve delayed-release, extended-release, and targeted-release profiles. Multiparticulate systems with different dose strengths can be obtained from the same batch of drug-loaded pellets without additional formulation or process modification. Pellets with different drugs or with different release profiles can be blended and formulated in a single-unit dosage form such as capsule, which promo...

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Controlled drug release from Gelucire-based matrix pellets: Experiment and theory

Cited by 43 publications

References 20 publications

On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: Functionalization, conjugation and drug release kinetics

Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process

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