On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

Zhang, Jilin; Rana, Subhasis; Srivastava, R. S.; Misra, R.D.K.

doi:10.1016/j.actbio.2007.06.006

Cited by 253 publications

(110 citation statements)

References 53 publications

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“…23 Folic acid binds to the folate receptors at cell surfaces with very high affinity and is internalized by receptor-mediated endocytosis. 24,26 More importantly, folic acid is stable, poorly immunogenic, and has the ability to target cancer cells preferentially because the folate receptor is frequently overexpressed on the surface of cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid

Saltan

Kutlu

Hür³

et al. 2011

IJN

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Background: Magnetic nanoparticles show great promise for use as tools in a wide variety of biomedical applications. The purpose of this study was to investigate the potential effects of methacrylamido-folic acid (Ma-Fol)-modified magnetic nanoparticles on 5RP7 (H- ras -transformed rat embryonic fibroblasts) and NIH/3T3 (normal mouse embryonic fibroblasts). Methods: The cytotoxicity and viability of 5RP7 and NIH/3T3 cells were detected. The percentage of cells undergoing apoptosis was analyzed by flow cytometry using Annexin V-fluorescein isothiocyanate staining. Nanoparticle internalization into 5RP7 and NIH/3T3 cells was visualized by transmission electron microscopy. Conclusion: In this study, folic acid coupled to the surface of iron oxide for selective binding to cancer cells and immobilized the surfaces of magnetic nanoparticles. This complex improves cell internalization and targeting of cancer cells. We detected increased apoptosis using flow cytometry and transmission electron microscopy. Results: Folic acid modification of magnetic nanoparticles could be used to facilitate uptake to specific cancer cells for cancer therapy and diagnosis. Our results showed that the uptake of folic-acid modified nanoparticles by 5RP7 cancer cells was also much higher than that of 3T3 cells. This modification can be used for successful targeting of cancer cells expressing the folate receptor.

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Section: Resultsmentioning

confidence: 99%

Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid

Saltan

Kutlu

Hür³

et al. 2011

IJN

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“…Hematite nanoparticles, crystallizing in the rhombohedral system and showing a weak ferromagnetic behavior at room temperature [1], have been extensively used as catalyst [2,3], pigment [4], gas sensor [5], optical devices [6], and medicine applications [7]. Magnetite and maghemite, instead, crystallizing in the cubic crystal system and with a ferromagnetic behavior at room temperature, have been widely exploited in technological applications including information storage [8], sensors [9], refrigeration [10], and coil cores [11], as well as in contrast agent for magnetic resonance imaging [12,13], and potential mediator for magnetic hyperthermia [14].…”

Section: Introductionmentioning

confidence: 99%

Ultrafine Magnetite Nanopowder: Synthesis, Characterization, and Preliminary Use as Filler of Polymethylmethacrylate Nanocomposites

Russo

Acierno

Palomba

et al. 2012

Journal of Nanotechnology

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Magnetite (Fe 3 O 4 ) nanoparticles prepared by microwave-assisted hydrothermal synthesis have been characterized in terms of morphological and structural features. Electron micrographs collected in both scanning (SEM) and transmission (TEM) modes and evaluations of X-ray powder diffraction (XRD) patterns have indicated the achievement of a monodispersed crystallite structure with particles having an average size around 15-20 nm. Structural investigations by Micro-Raman spectroscopy highlighted the obtainment of magnetite nanocrystals with a partial surface oxidation to maghemite (γ-Fe 3 O 4 ). Preliminary attention has been also paid to the use of these magnetite nanoparticles as filler for a commercial polymethylmethacrylate resin. Hybrid formulations containing up to 3 wt% of nanoparticles were prepared by melt blending and characterized by calorimetric and thermogravimetric tests. For sake of comparison, same formulations containing commercial Fe 3 O 4 nanoparticles are also reported. Calorimetric characterization indicates an increase of both glass transition temperature and thermal stability of the nanocomposite systems when loaded with the synthesized magnetite nanoparticles rather then loaded with the same amount of commercial Fe 3 O 4 . This first observation represents just one aspect of the promising potentiality offered by the novel magnetic nanoparticles when mixed with PMMA.

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“…The peaks at 1466, 1348 and 1279 cm -1 are attributed to the vibration of -CH 2 (Flesch et al, 2005a). The signal at 1240 cm -1 is attributed to the vibration of v(C-O) (Zhang et al, 2008). The band around 1105 cm -1 is due to the v(Si-O) vibration (Ma et al, 2003).…”

Section: Chemical Bonds In the Nanohybridsmentioning

confidence: 95%

Microwave synthesis of core-shell structured biocompatible magnetic nanohybrids in aqueous medium

Hu¹,

Percheron²,

Chaumont³

et al. 2011

Microwave Heating

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On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

Cited by 253 publications

References 53 publications

Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid

Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid

Ultrafine Magnetite Nanopowder: Synthesis, Characterization, and Preliminary Use as Filler of Polymethylmethacrylate Nanocomposites

Microwave synthesis of core-shell structured biocompatible magnetic nanohybrids in aqueous medium

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