Controlled drug delivery using the magnetic nanoparticles in non-Newtonian blood vessels

Abu‐Hamdeh, Nidal H.; Bantan, Rashad A. R.; Aalizadeh, Farhad; Alimoradi, Ashkan

doi:10.1016/j.aej.2020.07.010

Cited by 27 publications

(11 citation statements)

References 23 publications

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“…Targeted delivery of drugs can improve deficiencies in traditional therapies by delivering drugs to specific sites, improving the therapeutic efficacy. 3,4…”

Section: Introductionmentioning

confidence: 99%

“…Targeted delivery of drugs can improve deficiencies in traditional therapies by delivering drugs to specific sites, improving the therapeutic efficacy. 3,4 Hydrogels are considered to be ideal carriers for targeted drug delivery due to their good biocompatibility and gradual degradation in vivo. [5][6][7] A large number of studies have shown that the use of magnetic hydrogels can induce the on-demand release of drugs at the right place and time with the best concentration by precisely adjusting external stimuli, which can not only reduce the enzymolysis of drugs and toxicity to other tissues, but also extend the administration time.…”

Section: Introductionmentioning

confidence: 99%

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Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery

et al. 2023

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“…Targeted delivery of drugs can improve deficiencies in traditional therapies by delivering drugs to specific sites, improving the therapeutic efficacy. 3,4…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery

et al. 2023

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“…Using a finite difference method, Zaman et al 50 Investigated the effects of nanoparticles on unsteady blood flow through an overlapping stenosed channel and considered the appropriate boundary conditions. Assuming blood as a non-Newtonian fluid, Abu-Hamdeh et al 51 studied the effects of magnetic nanoparticles on a drug in blood vessels under the influence of magnetic fields. Using a three-dimensional finite element model, Gheflati and Naghavi 52 investigated the effects of uneven distribution of gold nanoparticles within the tumour and cooling effects of large blood vessels due to tumour temperature changes.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal analysis on non-Newtonian nanofluid flow of blood through porous vessels

Hosseinzadeh

Hasibi

2022

Proceedings of the Institution of Mechanical Engineers, Part E:

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In this paper, the flow of non-Newtonian blood fluid with nanoparticles inside a vessel with a porous wall in presence of a magnetic field have been investigated. This study aimed to investigate various parameters such as magnetic field and porosity on velocity, temperature, and concentration profiles. In this research, three different models (Vogel, Reynolds and Constant) for viscosity have been used as an innovation. The governing equations are solved by Akbari-Ganji's Method (AGM) analytical method and the Finite Element Method (FEM) is used to better represent the phenomena in the vessel. The results show that increasing the Gr number, porosity and negative pressure increase the blood velocity and increasing the magnetic field intensity decrease the blood velocity.

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“…Blood is a biomagnetic fluid that is made up of plasma, red blood cells, white blood cells and platelets (Srinivas et al , 2018). The red blood cells found there in the blood are usually made up of hemoglobin, the main component of which is iron (Abu-Hamdeh et al , 2020). The presence of iron allows blood to be magnetized in the presence of a magnetic field.…”

Section: Introductionmentioning

confidence: 99%

“…Abu-Hamdeh et al (2020) studied the controlled delivery of drugs using magnetic particles under the influence of a magnetic field. They considered blood to be non-Newtonian fluid.…”

Section: Introductionmentioning

confidence: 99%

Linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles: application to controlled drug delivery

Kapen

Ketchate

Tchuen

2021

HFF

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Purpose For this purpose, a linear stability analysis based on the Navier–Stokes and Maxwell equations is made leading to an eigenvalue differential equation of the modified Orr–Sommerfeld type which is solved numerically by the spectral collocation method based on Chebyshev polynomials. Unlike previous studies, blood is considered as a non-Newtonian fluid. The effects of various parameters such as volume fraction of nanoparticles, Casson parameter, Darcy number, Hartmann number on flow stability were examined and presented. This paper aims to investigate a linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles with an application to controlled drug delivery. Design/methodology/approach Targeted delivery of therapeutic agents such as stem cells and drugs using magnetic nanoparticles with the help of external magnetic fields is an emerging treatment modality for many diseases. To this end, controlling the movement of nanoparticles in the human body is of great importance. This study investigates controlled drug delivery by using magnetic nanoparticles in a porous artery under the influence of a magnetic field. Findings It was found the following: the Casson parameter affects the stability of the flow by amplifying the amplitude of the disturbance which reflects its destabilizing effect. It emerges from this study that the taking into account of the non-Newtonian character is essential in the modeling of such a system, and that the results can be very different from those obtained by supposing that the blood is a Newtonian fluid. The presence of iron oxide nanoparticles in the blood increases the inertia of the fluid, which dampens the disturbances. The Strouhal number has a stabilizing effect on the flow which makes it possible to say that the oscillating circulation mechanisms dampen the disturbances. The Darcy number affects the stability of the flow and has a stabilizing effect, which makes it possible to increase the contact surface between the nanoparticles and the fluid allowing very high heat transfer rates to be obtained. It also emerges from this study that the presence of the porosity prevents the sedimentation of the nanoparticles. By studying the effect of the magnetic field on the stability of the flow, it is observed that the Hartmann number keeps the flow completely stable. This allows saying that the magnetic field makes the dissipations very important because the kinetic energy of the electrically conductive ferrofluid is absorbed by the Lorentz force. Originality/value The originality of this paper resides on the application of the linear stability analysis for controlled drug delivery.

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Controlled drug delivery using the magnetic nanoparticles in non-Newtonian blood vessels

Cited by 27 publications

References 23 publications

Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery

Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery

Hydrothermal analysis on non-Newtonian nanofluid flow of blood through porous vessels

Linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles: application to controlled drug delivery

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