Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery

Qiao, Shishuai; Ouyang, Hao; Zheng, Xin-Qiang; Cheng, Qi; Ma, Li

doi:10.1039/d3tb00852e

Cited by 9 publications

(9 citation statements)

References 49 publications

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“…Other than moving through the GI tract via natural intestinal peristalsis, there are devices that utilize magnets as the actuators 32,33 . Magnetic actuation is appealing as it can penetrate the body without distorting the magnetic field.…”

Section: Novel Diagnostic Developments Of Smart Capsulesmentioning

confidence: 99%

The current and future clinical applications of capsule endoscopy

Ho,

Lui

2024

J of Gastro and Hepatol

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The current and future clinical applications of capsule endoscopyCapsule endoscopy (CE) has become an increasingly popular modality in facilitating the diagnosis of gastrointestinal tract pathologies that are beyond the reach of conventional endoscopy in the recent decades. Largely attributed to the lack of control of the capsule movement, most commercially available CEs are for diagnostic purposes at present. Yet, with the advancement in the capsule design and emerging technologies that allow for the manipulation and guidance of movement of the CE, it is anticipated that the roles of this medical device will be further expanded (Fig. 1).

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Section: Novel Diagnostic Developments Of Smart Capsulesmentioning

confidence: 99%

The current and future clinical applications of capsule endoscopy

Ho,

Lui

2024

J of Gastro and Hepatol

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“…251 As shown in Figure 12 (e), Qiao et al prepared a capsule microrobot based on hydrogel and equipped with a three-axis microfluidic chip, which is used to wrap drugs and deliver drugs in blood vessels. 252 Micro/nanorobots can also be utilized to transport biological agents for the treatment of metastatic tumors in the abdominal cavity. This technology holds great promise for targeted drug delivery and precise medical intervention in the management of such tumors.…”

Section: Medical Imagingmentioning

confidence: 99%

Review of the Applications of Micro/Nanorobots in Biomedicine

Zhang,

Tang,

Cao

et al. 2024

ACS Appl. Nano Mater.

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The advancement of precision medicine in modern biomedicine has been significantly propelled by the emergence of micro/nanorobots. The combination of micro/nanorobots and biomedicine offers unique advantages and holds attractive potential for applications. It effectively addresses the challenges encountered by traditional robots in areas such as driving, sensing, intelligence and other aspects, especially in the application of cancer and cardiovascular diseases, which is a hot field of interdisciplinary research in recent years. This review succinctly delineates and analyzes the recent advancements of micro/nanorobots. First, the research achievements of micro/nanorobots in recent years are systematically classified and introduced from four perspectives: manufacturing design, drive control, biomedical application and degradation. In particular, in-depth discussions were conducted regarding the challenges and potential solutions encountered in each stage. Second, based on the latest research results of micro/nanorobots in biomedical applications, the development direction of industrial applications and key technical aspects that need to be paid attention to are emphasized. Finally, we discuss the challenges and the potential research opportunities of the micro/nanorobots. In the future, it is expected that micro/nanorobots will become more sophisticated and capable of performing multiple medical functions and tasks. They will be implemented in vivo to assist medical doctors in diagnosing and treating diseases. This advancement shows significant potential for the field of medicine.

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“…The magnetic gel beads were a pH-and magnetic field-responsive asset in the drug delivery application. CaCO 3 /sodium alginate/Fe 3 O 4 hydrogel-based capsule microrobots were prepared by a triaxial microfluidic chip for intravascular targeted drug delivery [140]. After intravenous injection, the hydrogel-based capsule microrobots could reach the destination in blood vessels along the predetermined trajectory through an external magnetic field.…”

Section: Chitosan-based Micellar Hydrogels Minocycline and Edaravonementioning

confidence: 99%

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Zhao,

Zhou,

Zhang

et al. 2023

Pharmaceutics

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Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical applications of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing, and other biomedical fields are summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymers, novel technologies such as enzymatic and biological methods have been developed to improve their structural properties, and the development of new natural-based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels, and hydrogel microrobots have been designed to meet the advanced requirements in biomedical applications, and new strategies such as dual-cross-linking, microfluidic chip, micropatterning, and 3D/4D bioprinting have been explored to fabricate advanced hydrogel materials with designed properties for biomedical applications. Overall, natural polymeric hydrogels have attracted increasing interest in biomedical applications, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication are highly desirable and still challenging.

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Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery

Abstract: Microrobots for targeted drug delivery in blood vessels have attracted increasing interest from researchers. In this work, the hydrogel-based capsule microrobots is used to wrap drugs and deliver drugs in...

Cited by 9 publications

References 49 publications

The current and future clinical applications of capsule endoscopy

The current and future clinical applications of capsule endoscopy

Review of the Applications of Micro/Nanorobots in Biomedicine

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

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