Controlled Clinical Trials and Cross-Sectional Studies with Plasma Histamine Measurements and Histamine Receptor Antagonists: Solving the Problem of Preoperative H1- + H2- Prophylaxis by Asking New Questions?

Lorenz, W.; Sitter, H.; Stinner, B.; Duda, D.; Kapp, Bruce S.; Gstrein, B; Dietz, W.; Doenicke, A.; Dick, W.

doi:10.1007/978-3-0348-7309-3_14

Cited by 8 publications

(13 citation statements)

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“…In addition, histamine release in association with pain in a dentist's chair was demonstrated [90]. Combining these findings with the data from the literature in the first part of this article (especially KNIGGE and WARBERG [45]) made such an interpre- [75]. 6a: patients in the normal ward (in supine position).…”

Section: A Temptative Interpretationmentioning

confidence: 61%

“…Measurements and statistics They were described in detail in the protocol of the Mainz-Marburg trial [71], but also in the original paper about the second trial [75] and shortly in the short communications [98,102,103]. It is important to emphasize that all the four trials used the same rigid criteria for the fluorometricfluoroenzymatic plasma histamine assay as described by LORENZ et al [58] and modified by LORENZ and NEUGEBAUER [73] and demanded in the Consensus Conference on Histamine Assays [74].…”

Section: Methods Applied In All Four Trialsmentioning

confidence: 99%

“…Short communications were already published for all the trials in this article [14,98,102,103] as well as full papers on the definition and measurement of serial histamine release in these clinical conditions [13,71,75,96]. However, for a better understanding, details of the methods will be given in the following sections.…”

Section: Four Prospective Clinical Trials For Classification Of Histamentioning

confidence: 99%

“…Histamine release is a biochemical parameter, histamine release reaction is a clinical reaction which is diagnosed by the clinician using a set of signs and measurements [75]. According to LORENZ et al [66] histamine release reactions show 3 grades of severity: cataneous, systemic and life-threatening.…”

Section: Definition Of Histamine Release and Of A Systemic Histamine mentioning

confidence: 99%

“…No answer can be given yet_ In the definition of stress by MoRsE et al [82] this complex life and clinical scenario includes 3 components: stressors, individual make-up and the stress response. All three components guarantee a high variability in measured physical and biochemical parameters which also for stressinduced histamine release predicts non-responders, responders and superresponders as in the case of drug-induced pseudoallergic histamine release [63,66,75]. Upper gastrointestinal endoscopy with modern (small diameter) equipment, but without premedication in patients undergoing routine endoscopy (age about 50, with concomitant diseases) comprises many factors of stress in all three subgroups [82]: 1) physical and several psychological stressors, especially anxiety ; 2) make-up factors including age, personality (type As vs type Bs), traits and attitudes, emotional instability, etc.…”

Section: A Temptative Interpretationmentioning

confidence: 99%

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Perioperative nonspecific histamine release : a new classification by aetiological mechanisms and evaluation of their clinical relevance

Duda¹,

Lorenz

Menke

et al. 1993

Annales Françaises d'Anesthésie et de Réanimation

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RI~SUM#: Les auteurs ont r6alis6 quatre 6tudes prospectives dans le but d'6tudier les diff6rents facteurs responsables de la lib6ration d'histamine dans la p6riode p6dop6ratoire. Les r6actions allergiques vraies et les r6actions pseudo-allergiques ne sont pas seules en cause. De nombreux autres m6canismes d'histaminolib6ration sont sugg6r6s : m6canismes neuroendocriniens, lib6ration cons6cutive ,~ des stimuli nociceptifs, facteurs cytotoxiques cons6cutifs au traumatisme tissulaire de l'acte chirurgical et lib6ration induite par les cytokines. Ces mdcanismes ont 6t6 mis en 6vidence darts deux 6tudes prospectives 6tudiant, l'une des patients lors d'une gastroscopie r6alis6e sans pr6m6dication et l'autre, des patients b6n6ficiant d'une chol6cystectomie perccelioscopique. Darts une autre 6tude, une histaminolib6ration par mdcanisme pseudoallergique a 6t6 not6e imm6diatement apr~s l'induction anesth6sique chez un hombre important de patients op6r6s pour divers acres de chirurgie g6n6rale. Dans ces deux cas, I'histaminolib6ration est ind6sirable car elle est ~a l'origine de sympt6mes de gravit6 variable. Les signes cliniques sont surtout cardiovasculaires et respiratoires alors que les signes cutan6s sont souvent absents. Les auteurs consid~-rent que dans la pdriode p6riop6ratoire la lib6ration d'histamine est ind6sirable dans certains cas mais darts d'autres elle n'a pas de cons6quences n6fastes, pouvant m6me 6tre b6n6fique. Une r66valuation des signes cliniques d'histaminolib6ration est n6cessaire puisque les 6tudes ont montr6 que des concentrations plasmatiques de 12 ng. ml -~ d'histamine souvent ne s'accompagnaient d'aucun signe cutan6. Ainsi une histaminolib6ration non sp6cifique n'est, le plus souvent, pas reconnue comme cause d'une hypotension art6rielle p6riop6ratoire en raison du manque de sp6cificit6 de ce sympt6me. Des 6tudes ult6rieures doivent pr6ciser le r61e des m6dicaments antihistaminiques (anti-H1 et anti-H2, doses, choix des patients, moment de Fadministration) darts la pr6vention de l'histaminolib6ration p6riop6ratoire. CLASSIFICATION OF PERIOPERATIVE HISTAMINE RELEASEIn the last conference on prevention of perianaesthetic anaphylactoid reactions, Nancy, 1984 [52], a whole series of mechanisms for nonspecific histamine release was not mentioned at all [62]. Surgical trauma was included, but only one reference could be given at this time [93] and did not challenge the general opinion over 50 years that ,~ histamine does not play an important role in major injury or traumatic shock, [1, 311In this conference [54], however, a considerable increase of knowledge has to b~ reported which creates new hypotheses on functions of histamine in clinical epidemiology ( fig. 1). A new classification has to be found which does not only alter aetiology, but also pathogenesis and disease manifestations, especially in the perioperative and postoperativ e period.

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Section: A Temptative Interpretationmentioning

confidence: 61%