Controlled Cell Adhesion on PEG‐Based Switchable Surfaces

Wischerhoff, Erik; Uhlig, Katja; Lankenau, Andreas; Börner, Hans G.; Laschewsky, André; Duschl, Claus; Lutz, Jean‐François

doi:10.1002/anie.200801202

Cited by 353 publications

(335 citation statements)

References 57 publications

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“…At lower grafting densities the "mushroom regime" is defined. Termed "polymer brushes", these materials have an assortment of applications and particularly, the ability to alter surface properties including bio-adhesion [1], wettability [2], modulating interfacial electronic properties [3], and surface activity [4]. Often these properties are classified under the broader term of "responsive surfaces" [5].…”

Section: Introductionmentioning

confidence: 99%

From Self-Assembled Monolayers to Coatings: Advances in the Synthesis and Nanobio Applications of Polymer Brushes

et al. 2015

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Abstract:In this review, we describe the latest advances in synthesis, characterization, and applications of polymer brushes. Synthetic advances towards well-defined polymer brushes, which meet criteria such as: (i) Efficient and fast grafting, (ii) Applicability on a wide range of substrates; and (iii) Precise control of surface initiator concentration and hence, chain density are discussed. On the characterization end advances in methods for the determination of relevant physical parameters such as surface initiator concentration and grafting density are discussed. The impact of these advances specifically in emerging fields of nano-and bio-technology where interfacial properties such as surface energies are controlled to create nanopatterned polymer brushes and their implications in mediating with biological systems is discussed.

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Section: Introductionmentioning

confidence: 99%

From Self-Assembled Monolayers to Coatings: Advances in the Synthesis and Nanobio Applications of Polymer Brushes

et al. 2015

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“…The upcoming of oligo(ethylene oxide)-based macromonomers has allowed different macromolecular architectures that have been recognized as ''smart'' biorelevant materials. [12][13][14][15][16][17][18] The polymerization of (meth)acrylates with PEG side chains has been carried out by ATRP under different conditions showing high polymerization rates in aqueous media. 19 The limit of ATRP control has been explored through a detailed study of the solvent effects on ATRP of oligo(ethylene glycol) methacrylate.…”

mentioning

confidence: 99%

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Luzon

Corrales

Catalina

et al. 2010

J. Polym. Sci. A Polym. Chem.

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A series of amphiphilic triblock copolymers, poly [oligo(ethylene glycol) methacrylate] x -block-poly(e-caprolactone)-block-poly[oligo(ethylene glycol) methacrylate] x , POEGMA Co (x), were synthesized. Formation of hydrophobic domains as cores of the micelles was studied by fluorescence spectroscopy. The critical micelle concentrations in aqueous solution were found to be in the range of circa 10 À6 M. A novel methodology by modulated temperature differential scanning calorimetry was developed to determine critical micelle temperature. A significant concentration dependence of cmt was found. Dynamic light scattering measurements showed a bidispersed size distribution.The micelles showed reversible dispersion/aggregation in response to temperature cycles with lower critical solution temperature between 75 and 85 C. The interplay of the two hydrophobic and one thermoresponsive macromolecular chains offers the chance to more complex morphologies. V C 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: [4909][4910][4911][4912][4913][4914][4915][4916][4917][4918][4919][4920][4921] 2010

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“…18,19 Therefore, SPR sensing has been widely used in applications in different fields e.g., medical diagnostics, biopharmaceutical, environmental monitoring and food security. 20,21 However, SPR sensing has some deficiencies mainly due to strong nonspecific adsorption of the SPR chip surface, which limits this method in practical applications. 22,23 To address this drawback, surface modified SPR chips can be considered.…”

Section: Introductionmentioning

confidence: 99%

Effects of Interfacial Properties of a Surface Modified Surface Plasmon Resonance Chip on Protein Immobilization Performance

Jiang

Wang

et al. 2017

ANAL. SCI.

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In order to confirm the correlation between interfacial properties of modified surface plasmon resonance (SPR) chips and their SPR responses to immobilized anti-IgG, SPR chips were modified by mercaptoundecanoic acid, poly(ethylene glycol) diacrylate (PEG), PEG-based copolymer and cyclodextrin coupled PEG using self-assembled or radical polymerization methods. The resulting interfacial properties such as film thickness and hydrophilicity were characterized by AFM, elliptic polarization scanners and contact angle meter. Immobilization of human IgG on the modified chips was achieved by EDC/NHS activation through an amide bond. The association between fixed IgG and free anti-IgG was reflected by the variation of SPR responses and the binding ability was evaluated by Langmuir isotherms. As observed, the adsorption between IgG and anti-IgG was affected by the interfacial properties of different modifiers, such that a chip with a thinner and more hydrophilic layer may result in a higher SPR response, producing a larger adsorption equilibrium constant for protein interaction.

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Controlled Cell Adhesion on PEG‐Based Switchable Surfaces

Cited by 353 publications

References 57 publications

From Self-Assembled Monolayers to Coatings: Advances in the Synthesis and Nanobio Applications of Polymer Brushes

From Self-Assembled Monolayers to Coatings: Advances in the Synthesis and Nanobio Applications of Polymer Brushes

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Effects of Interfacial Properties of a Surface Modified Surface Plasmon Resonance Chip on Protein Immobilization Performance

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