Controlled and localized drug delivery using Titania nanotubes

Kumar, Amogh; Gopalram, Keerthiga; Mohan, L.; Dutta, Sayan Deb; Gupta, Pallavi; Lim, Ki-Taek; Santra, Tuhin Subhra

doi:10.1016/j.mtcomm.2022.103843

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Localised drug delivery using DRI has been extensively studied in temporary and permanent implants to deliver anti-microbial agents and bone growth factors [ 115 ]. Polymer coatings control the targeted drug delivery and can be extended to the surface modifications for corrosion control of Mg alloys [ 116 ].…”

Section: Advances In Polymer Coatings For Mg Alloymentioning

confidence: 99%

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

et al. 2023

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Magnesium (Mg) alloys are a very attractive material of construction for biodegradable temporary implants. However, Mg alloys suffer unacceptably rapid corrosion rates in aqueous environments, including physiological fluid, that may cause premature mechanical failure of the implant. This necessitates a biodegradable surface barrier coating that should delay the corrosion of the implant until the fractured/damaged bone has healed. This review takes a brief account of the merits and demerits of various existing coating methodologies for the mitigation of Mg alloy corrosion. Since among the different coating approaches investigated, no single coating recipe seems to address the degradation control and functionality entirely, this review argues the need for polymer-based and biodegradable composite coatings.

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Section: Advances In Polymer Coatings For Mg Alloymentioning

confidence: 99%

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

et al. 2023

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“…[17] Poly(methacrylic acid) (PMAA)-based nanogels have also emerged as promising drug carriers, offering unique advantages such as high drug loading capacity and tunable release profiles. [18][19][20] However, each drug delivery system presents its own set of advantages and limitations. For instance, while P(MAA-EGDMA) exhibits a higher drug loading capacity, its initial burst release may pose challenges.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, their strongly hydrophilic nature further enhances their utility in drug delivery applications [17] . Poly(methacrylic acid) (PMAA)‐based nanogels have also emerged as promising drug carriers, offering unique advantages such as high drug loading capacity and tunable release profiles [18–20] . However, each drug delivery system presents its own set of advantages and limitations.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Ciprofloxacin‐Loaded Nanoparticles (Titania, Silica, and P(MAA‐EGDMA)) for Controlled Drug Release and Improved Antibacterial Effectiveness

Sanattalab,

Gürdağ,

Sıgırcı

2024

ChemistrySelect

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In this study, spherical silica, titania and poly(methacrylic acid‐ethylene glycol dimethacrylate) (P(MAA‐EGDMA)) nanoparticles (NPs) were synthesized and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), dynamic light scattering (DLS), Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), and UV spectroscopy methods. Ciprofloxacin (CIP) was selected as the drug sample for this study. The loading of CIP onto NPs was accomplished through different methods based on the type of NP used. Although P(MAA‐EGDMA) has higher CIP loading capacity compared to silica and titania nanocarriers, it was observed that the total release amount was less than titania NPs and a littele bit more than silica NPs. The CIP content of NPs was found to be approximately 7 % for both titania and silica, whereas it was observed to be 40 % for P(MAA‐EGDMA). P(MAA‐EGDMA)@CIP released 60ng of CIP over 18 hours, while silica@CIP released 38 ng over the same period. Titania@CIP released 600 ng within 6 hours, showing a tenfold increase compared to the other systems. Interestingly, silica@CIP did not start releasing CIP within 1.5 hours, whereas P(MAA‐EGDMA)@CIP released up to 50 % within the same timeframe. The antibacterial activities of all CIP‐delivery systems were thoroughly examined and compared against a range of bacteria including P. aeruginosa, E. coli, S. typhimurium, K. pneumonia, S. epidermidis, S. aureus, B. subtilis, B. cereus, and E. Faecalis. Combining titania with CIP resulted in a decrease in antibacterial effect in most bacteria, except for E. coli and S. Typhimurium, where it notably increased to 10 μg/mL. However, the combination showed effectiveness against other bacteria, albeit with a significant reduction compared to individual substance use. These results highlight titania‘s potential as an antibacterial agent against P. aeruginosa, with a lower MIC value compared to CIP.

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“…The drug delivery systems based on TiO 2 nanotube arrays (TNTs) have been applied in many fields consisting of dental implants, and joint prosthesis, because of their series of advantages, such as excellent biocompatibility, chemical stability, and corrosion resistance [1][2][3]. Nevertheless, low drug availability due to the existence of sudden release of drugs at the release stage and drugs not being released on demand were proven to be disadvantages of such systems.…”

Section: Introductionmentioning

confidence: 99%

Self‐trigger and on‐demand drug delivery system based on TiO₂ nanotube arrays and its drug release behaviour

Zhang

Liu

Xiao

2023

Micro & Nano Letters

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The foundation of drug delivery systems based on titanium dioxide nanotube arrays has become an important means to increase the drug release performance of bone implantation materials. However, most of the conventional platforms have some disadvantages, such as large sudden release, uncontrollable, unintelligent, or not on‐demand drug release process. Herein, the authors develop a unique self‐triggering drug release system (SDDS), utilizing the advantages of 1‐Tetradecanol (TD), such as decent biocompatibility, a phase transition temperature of 37.8°C, and the inexistence of complex chemical reaction process. The establishment of the platform can make a large amount of the anti‐inflammatory drug (ibuprofen, IBU) released when the body or the affected area is inflamed, that is, when the temperature rises. Conversely, only a small amount or no drug is released when there is no inflammation, thereby achieving self‐trigger release and on‐demand release. The experimental results show that the system combines good self‐trigger release properties, release sensitivity, drug release cycle, and low selectivity to the loaded drugs.

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Controlled and localized drug delivery using Titania nanotubes

Cited by 3 publications

References 26 publications

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

Analysis of Ciprofloxacin‐Loaded Nanoparticles (Titania, Silica, and P(MAA‐EGDMA)) for Controlled Drug Release and Improved Antibacterial Effectiveness

Self‐trigger and on‐demand drug delivery system based on TiO₂ nanotube arrays and its drug release behaviour

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Controlled and localized drug delivery using Titania nanotubes

Cited by 3 publications

References 26 publications

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

Analysis of Ciprofloxacin‐Loaded Nanoparticles (Titania, Silica, and P(MAA‐EGDMA)) for Controlled Drug Release and Improved Antibacterial Effectiveness

Self‐trigger and on‐demand drug delivery system based on TiO2 nanotube arrays and its drug release behaviour

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Self‐trigger and on‐demand drug delivery system based on TiO₂ nanotube arrays and its drug release behaviour