Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

Keerthiga, G.; Prasad, M.J.N.V.; Vijayshankar, Dandapani; Singh, Raman Raghuvir Kumar

doi:10.3390/ma16134700

Cited by 8 publications

(4 citation statements)

References 118 publications

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“…Numerous types of biopolymer composite coatings. [85,87,88,103] the Mg substrate was satisfactory, reaching higher than 70 N bonding forces. In another investigation, Mahmoodi et al [108] used the EDP technique to produce hydroxyapatite (HA)chitosan nanocomposite coatings from alcoholic suspensions.…”

Section: Biopolymer Composite Coatingsmentioning

confidence: 90%

“…[83,84] Various coating techniques have been employed to create functional polymeric layers on Mg alloys, including PEO, anodization, hydrothermal coating, MAO, chemical CCs, PVD, radiofrequency magnetron sputtering, and others. [85,86] Examples of polymeric coatings include biodegradable polymer-based coatings, biofunctionalized anticorrosive silane coatings, and self-assembled coatings. Specific biopolymers used for coatings include polyvinylidene fluoride, chitosan, alginate, cellulose, hyaluronic acid, cellulose acetate, chitin, and heparin.…”

Section: Polymeric Coatingsmentioning

confidence: 99%

“…[103] Other types of coatings used on Mg-based implants and biomaterials include inorganic coatings like hydroxyapatite (HA), as well as metallic and synthetic polymer coatings. [85,88] Ordikhani and Simchi [104] fabricated bioactive drug-eluting chitosan-based coatings using the EPD technique on the titanium bone implant. Their produced composite biopolymer contained 23.7 wt% bioactive glass particles with different ratios of vancomycin antibiotic, resulting in long-term drug delivery ability along with favorable apatite generation and cell adhesion and growth.…”

Section: Biopolymer Composite Coatingsmentioning

confidence: 99%

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Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Li,

Kong,

Zhang

2024

Adv Eng Mater

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Multifunctional materials are propitious materials with numerous functionalities that make them an ideal option for implants and biomedical applications that should simultaneously fulfill various requirements, including satisfactory mechanical strength, biocompatibility, antibacterial property, hydrophilicity, drug delivery, etc. Magnesium, as a metallic biomaterial, fulfills the required mechanical properties, but unfortunately, in some ways alone, it cannot provide the required biological properties. For instance, Mg alloys suffer from poor corrosion resistance and high biodegradability, which should be carefully controlled. On the other hand, multifunctional materials alone are not able to provide the required properties in biomedical applications because the vast majority of them do not have the necessary strength and stability. Therefore, the use of magnesium together with multifunctional or composite coatings will be a very advantageous choice for meeting the needs of implants and biomedical materials. The current study focuses on the introduction and utilization of various multifunctional coatings and composites on Mg‐based alloys for biomedical applications. Numerous organic and inorganic materials could be utilized as composites or multifunctional materials, such as polymers, hydroxyapatites, hydrogels, calcium phosphates, alginates, hyaluronic acids, chitosan, etc. In this regard, numerous types of coating and composite materials, their production technologies, mechanisms, resultant properties, and the involved parameters are thoroughly discussed to provide a comprehensive guide for those interested in this field. It is hoped that this study will pave the way for the production of advanced and smart multifunctional materials with unique properties and play a role in the design of a new generation of Mg‐based biomedical materials.This article is protected by copyright. All rights reserved.

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Section: Biopolymer Composite Coatingsmentioning

confidence: 90%

Section: Polymeric Coatingsmentioning

confidence: 99%

Section: Biopolymer Composite Coatingsmentioning

confidence: 99%

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Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Li,

Kong,

Zhang

2024

Adv Eng Mater

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“…However, the fast corrosion rate of Mg metals may lead to mechanical integrity loss at an early stage before the completion of bone defect reconstruction, which will lead to the failure of surgery. 121 Thus, alloying with antitumor elements or coating with antitumor layers may be useful strategies to simultaneously enhance the anticorrosion and antitumor effects of Mg-based implants and facilitate the advancement of such innovative medical devices to repair bone defects caused by tumor curettage.…”

Section: Strategies To Improve the Anticorrosion And Antitumor Effect...mentioning

confidence: 99%

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

Lin,

Wei,

Yang

2024

APL Bioengineering

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As a primary malignant bone cancer, osteosarcoma (OS) poses a great threat to human health and is still a huge challenge for clinicians. At present, surgical resection is the main treatment strategy for OS. However, surgical intervention will result in a large bone defect, and some tumor cells remaining around the excised bone tissue often lead to the recurrence and metastasis of OS. Biomedical Mg-based materials have been widely employed as orthopedic implants in bone defect reconstruction, and, especially, they can eradicate the residual OS cells due to the antitumor activities of their degradation products. Nevertheless, the fast corrosion rate of Mg alloys has greatly limited their application scope in the biomedical field, and the improvement of the corrosion resistance will impair the antitumor effects, which mainly arise from their rapid corrosion. Hence, it is vital to balance the corrosion resistance and the antitumor activities of Mg alloys. The presented review systematically discussed the potential antitumor mechanisms of three corrosion products of Mg alloys. Moreover, several strategies to simultaneously enhance the anticorrosion properties and antitumor effects of Mg alloys were also proposed.

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Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges

Tang,

Fischer,

Kong

et al. 2024

BMEMat

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Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost, morbidity, and even mortality. This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials. The forms of manufacturing and synthesizing hybrid coatings were first discussed. We then categorize these coatings based on their biological functions: antibacterial coatings, which are essential for preventing difficult‐to‐treat infection; coatings designed to promote osseointegration, crucial for the mechanical stability of implants; coatings that encourage soft tissue attachment, contributing to the overall success and esthetics of implant. We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative, holistic approach for reducing implant complications. The review culminates in a discussion on future directions in the field, emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients. Together, our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.

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Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review

Cited by 8 publications

References 118 publications

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges

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