Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells

Han, Jinpeng; Cui, Yuchen; Gu, Zi; Yang, Dayong

doi:10.1016/j.biomaterials.2021.120846

Cited by 57 publications

(44 citation statements)

References 44 publications

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“…Our group has successfully developed photoresponsive DNA nanocarriers that are able to change the morphology of the containers for potential drug release in response to light irradiation in a remote-controlled manner [ 206 , 219 ]. Recently, Yang‘s group reported the use of controllable association/dissociation of DNA/polyphenol nanoassemblies for cascade-responsive and sequential drug release in cancer cells [ 220 ]. Addition of tannic acid (TA)acts as a linker to mediate self-assembly of branched DNA tiles loaded with antisense DNA and DNAzyme to form a nanocomplex.…”

Section: Discussionmentioning

confidence: 99%

Nucleic Acids and Their Analogues for Biomedical Applications

Wang

Chu

et al. 2022

Biosensors

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Nucleic acids are emerging as powerful and functional biomaterials due to their molecular recognition ability, programmability, and ease of synthesis and chemical modification. Various types of nucleic acids have been used as gene regulation tools or therapeutic agents for the treatment of human diseases with genetic disorders. Nucleic acids can also be used to develop sensing platforms for detecting ions, small molecules, proteins, and cells. Their performance can be improved through integration with other organic or inorganic nanomaterials. To further enhance their biological properties, various chemically modified nucleic acid analogues can be generated by modifying their phosphodiester backbone, sugar moiety, nucleobase, or combined sites. Alternatively, using nucleic acids as building blocks for self-assembly of highly ordered nanostructures would enhance their biological stability and cellular uptake efficiency. In this review, we will focus on the development and biomedical applications of structural and functional natural nucleic acids, as well as the chemically modified nucleic acid analogues over the past ten years. The recent progress in the development of functional nanomaterials based on self-assembled DNA-based platforms for gene regulation, biosensing, drug delivery, and therapy will also be presented. We will then summarize with a discussion on the advanced development of nucleic acid research, highlight some of the challenges faced and propose suggestions for further improvement.

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Section: Discussionmentioning

confidence: 99%

Nucleic Acids and Their Analogues for Biomedical Applications

Wang

Chu

et al. 2022

Biosensors

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“…Based on that, exquisitely designed polyphenol-DNA nanocomplex with controllable assembly/disassembly behaviors was developed for responsive gene/drug release in cancer cells (Figure 6). [26] Specifically, two therapeutic genes including antisense DNA and DNAzyme were incorporated into branched-DNA. In the presence of TA, the branched-DNA could assemble with DNA aptamer which was occupied to improve the tumortargeting capacity.…”

Section: Dna-ta Nanomaterialsmentioning

confidence: 99%

mentioning

confidence: 99%

Dynamic Transformation of DNA Nanostructures inside Living Cells

Ding

Lü

et al. 2022

ChemPlusChem

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DNA nanostructures, that show sequence programmable responsiveness to intracellular signals, have been explored as potential candidates of artificial dynamic functional structures in living cells. Recently, we developed a series of intracellular signals responding DNA nanostructures in living cells to perform a special mission. In this review, the developed DNA nanostructures and their dynamic transformation properties are summarized and discussed. The DNA nanostructures are generally categorized into DNA-inorganic nanomaterials and DNA-organic nanomaterials depending on the composition. At the end of this review, the challenges and prospects on instructing dynamic DNA nanostructures in living cells are discussed. We believe that this review will contribute to the further development of stimuli-responsive nanomaterials, which is of great potential in biomedical applications.

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“…In addition, the structural features of polyphenol also endowed strong interactions with nucleic acids to fabricate DNA-organic formulations, which demonstrated sufficient loading efficiency of gene drugs. In this regard, we employed tannic acid (TA) to mediate the assembly process of the dynamic nanocomplex system (Figure 6A; Han et al, 2021a). In the composite system, Y-shaped DNA and linear DNA assembled into branched skeleton through complementary base pairing and formed nanocomposites with TA driven by hydrogen bonding.…”

Section: Dna-organic Nanomaterialsmentioning

confidence: 99%

DNA Functional Nanomaterials for Controlled Delivery of Nucleic Acid-Based Drugs

Lü

Zhu

2021

Front. Bioeng. Biotechnol.

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Nucleic acid-based drugs exhibited great potential in cancer therapeutics. However, the biological instability of nucleic acid-based drugs seriously hampered their clinical applications. Efficient in vivo delivery is the key to the clinical application of nucleic acid-based drugs. As a natural biological macromolecule, DNA has unique properties, such as excellent biocompatibility, molecular programmability, and precise assembly controllability. With the development of DNA nanotechnology, DNA nanomaterials have demonstrated significant advantages as delivery vectors of nucleic acid-based drugs by virtue of the inherent nucleic acid properties. In this study, the recent progress in the design of DNA-based nanomaterials for nucleic acid delivery is summarized. The DNA nanomaterials are categorized according to the components including pure DNA nanomaterials, DNA-inorganic hybrid nanomaterials, and DNA-organic hybrid nanomaterials. Representative applications of DNA nanomaterials in the controlled delivery of nucleic acid-based drugs are exemplified to show how DNA nanomaterials are rationally and exquisitely designed to address application issues in cancer therapy. At the end of this study, the challenges and future development of DNA nanomaterials are discussed.

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Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells

Cited by 57 publications

References 44 publications

Nucleic Acids and Their Analogues for Biomedical Applications

Nucleic Acids and Their Analogues for Biomedical Applications

Dynamic Transformation of DNA Nanostructures inside Living Cells

DNA Functional Nanomaterials for Controlled Delivery of Nucleic Acid-Based Drugs

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