Control of β-carotene bioaccessibility using starch-based filled hydrogels

Mun, Saehun; Kim, Yong‐Ro; McClements, David Julian

doi:10.1016/j.foodchem.2014.10.053

Cited by 151 publications

(61 citation statements)

References 46 publications

(49 reference statements)

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“…15,16 These digestible lipids greatly enhance the delivery of bioactive compounds in the small intestine by increasing the number of mixed micelles, which generally enhance solubility and transport of hydrophobic bioactive compounds. [17][18][19][20][21][22][23] Many studies have focused on the health beneficial aspects of nanophytobioactive compounds to reduce oxidative stress and treat neurological disorders and PD. [24][25][26][27][28] Nanocurcumin shows a higher mean residential time in the mice brain than that of natural curcumin.…”

Section: Introductionmentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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Section: Introductionmentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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“…This was likely because of its tight binding of the β‐lactoglobulin and palm oil which protected the nanoparticles from pepsin degradation. Compared with other large (sodium casein and denatured starch) or small molecular (Tween‐20, ML750) emulsifiers, WPI is more effective to protect beta‐carotene (Mao, Yang, Xu, Yuan, & Gao, 2010; Mun, Kim, & McClements, 2015; Zhang, Zhang, Zhang, Decker, & McClements, 2015a) because of the high content of beta‐lactoglobulin (~50%) that highly resists pepsin hydrolyzation (Hur, Decker, & McClements, 2009). …”

Section: Resultsmentioning

confidence: 99%

Stability and in vitro digestibility of beta‐carotene in nanoemulsions fabricated with different carrier oils

Zhou

Wang

et al. 2018

Food Science & Nutrition

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Beta‐carotene, the main dietary source of provitamin A, is required for maintaining optimum human health. The bioaccessibility of beta‐carotene can be greatly improved when ingested with fat. Therefore, the aim of the current study was to select proper oils (palm oil, coconut oil, fish oil, and corn oil) as a carrier to form stable nanoemulsion that can effectively enhance the bioaccessibility of beta‐carotene. The nanoemulsion was formulated with 90% (v/v) aqueous solution (2% whey protein isolate, WPI, w/v) and 10% (v/v) dispersed oil. The in vitro digestion experiment of nanoemulsions showed that the bioaccessibility of beta‐carotene was as followed in order: palm oil = corn oil > fish oil > coconut oil (p < 0.05). The particle size of the nanoemulsion (initial particle size = 168–185 nm) was below 200 nm during 42 days’ storage at 25°C. The retention rates of beta‐carotene in nanoemulsions were 69.36%, 63.81%, 49.58%, and 54.91% with palm oil, coconut oil, fish oil, and corn oil, respectively. However, the particle size of the nanoemulsion increased significantly in the accelerated experiment at 55°C (p < 0.05), in which the retention rates of beta‐carotene were 48.56%, 43.41%, 29.35%, and 33.60% with palm oil, coconut oil, fish oil, and corn oil, respectively. From above, we conclude that WPI‐stabilized beta‐carotene nanoemulsion with palm oil as the carrier is the most suitable system to increase bioaccessibility and stability of lipid‐soluble bioactive compounds such as beta‐carotene.

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“…Bu durumun niflastan›n, B. Hızlar, S. Karakaya lipit damlac›klar›n›n a¤›z ve mide içerisinde agregasyonunu önlemesi ve bu yolla lipaz›n lipit faz›na erifliminin artmas›ndan ileri geldi¤i düflünülmektedir. Ayn› zamanda niflastan›n ortamda bulunmas›, gastrointestinal s›v›da β-karoten içeren misellerde yer alan proteinin çökelmesini engellemifltir (39,40). Pektin gibi çözünebilir liflerin diyetteki ya¤lar›n sindirimi süresince gerçekleflen fizikokimyasal olaylar› ve karotenoidler gibi lipofilik mikro besin ögeleri emilimini etkiledi¤i bilinmektedir.…”

Section: B Hızlar S Karakayaunclassified

Eksi̇pi̇yan Gida Ve Emülsi̇yonlarin Karotenoi̇d Bi̇yoeri̇şi̇lebi̇li̇rli̇ği̇ Üzeri̇ne Etki̇si̇

Hızlar¹,

Karakaya²

2017

GIDA

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ÖzSon y›llarda beslenme alan›ndaki araflt›rmalar karotenoidlerin biyoeriflilebilirli¤i ve biyoyaray›fll›l›¤› üzerine yo¤unlaflm›flt›r. Karotenoidlerin lipofilik yap›s› ve bitkisel g›dalardaki spesifik lokalizasyonunun bir sonucu olarak, genellikle çi¤ meyve ve sebzelerdeki biyoeriflilebilirlikleri ve biyoyaray›fll›l›klar› düflüktür. Çünkü karotenoidlerin emilimlerinden önce hücre matriksinden aç›¤a ç›kmalar› ve sindirim s›ras›nda lipit faz›na geçmeleri gerekmektedir. Karotenoidler gibi lipofilik karakterdeki biyoaktif bilefliklerin ço¤unun biyoyaray›fll›l›¤› suda çözünürlü¤ün düflük olmas›, yüksek erime s›cakl›¤› ve kimyasal stabilitenin zay›f olmas› gibi nedenlerle düflüktür. Bu sorunu çözmeye yönelik günümüz yaklafl›m›, g›da matriksinin dizayn edilmesidir. Bu kapsamda araflt›rmalar halen devam etmektedir. Ancak en yeni yaklafl›m faydal› etkinin eksipiyan g›dalarla art›r›lmas›d›r. Buradaki temel fikir g›dan›n, kompozisyonu ve/veya yap›s› sa¤l›k faydas›n› art›racak flekilde özel olarak dizayn edilmifl di¤er bir g›da ile (eksipiyan g›da) birlikte tüketilmesidir. Bu makalede g›da matriksinin ve yap›s›n›n karotenoid biyoeriflilebilirli¤i üzerine etkisi ve bu bilgiler ›fl›¤›nda dizayn edilen eksipiyan g›da ve emülsiyonlarla ilgili yap›lan çal›flmalar derlenmifltir.Anahtar kelimeler: Eksipiyan g›da, eksipiyan emülsiyon, karotenoidler, biyoeriflilebilirlik, biyoyaray›fll›l›k THE EFFECTS OF EXCIPIENT FOODS AND EMULSIONS ON CAROTENOID BIOACCESSIBILITY AbstractRecently, increasing attention has been given to carotenoid bioaccessibility and bioavailability in the field of nutrition research. As a consequence of their lipophilic nature and their specific localization in plant-based tissues, carotenoid bioaccessibility and bioavailability is generally quite low in raw fruits and vegetables, since carotenoids need to be released from the cellular matrix and incorporated in the lipid fraction during digestion before being absorbed. However, the poor water-solubility, high melting point, and low oral bioavailability of lipophilic bioactive agents like carotenoids make them difficult to incorporate into many aqueous-based food products and may reduce their bioaccessibility within the gastrointestinal tract. Today's approach related to improve bioaccessibility is to design of food matrix. Recently, the newest approach, excipient food, has been introduced to improve the bioavailability of orally administered bioactive compounds. The main idea is combining food and another food (the excipient food) whose composition and/or structure is specifically designed to improve health benefits. This article reviews studies related to the impact of food matrix and structure on the bioaccessibility of carotenoids, and excipient foods and emulsions designed in the light of this knowledge.

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Control of β-carotene bioaccessibility using starch-based filled hydrogels

Cited by 151 publications

References 46 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Stability and in vitro digestibility of beta‐carotene in nanoemulsions fabricated with different carrier oils

Eksi̇pi̇yan Gida Ve Emülsi̇yonlarin Karotenoi̇d Bi̇yoeri̇şi̇lebi̇li̇rli̇ği̇ Üzeri̇ne Etki̇si̇

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Control of β-carotene bioaccessibility using starch-based filled hydrogels

Cited by 151 publications

References 46 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Stability and in vitro digestibility of beta‐carotene in nanoemulsions fabricated with different carrier oils

Eksi̇pi̇yan Gida Ve Emülsi̇yonlarin Karotenoi̇d Bi̇yoeri̇şi̇lebi̇li̇rli̇ği̇ Üzeri̇ne Etki̇si̇

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Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models