Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial

Wawer, Maria J.; Sewankambo, Nelson; Serwadda, David; Quinn, Thomas C.; Kiwanuka, Noah; Li, Chuanjun; Lutalo, Thomas; Nalugoda, Fred; Gaydos, Charlotte A.; Moulton, Lawrence H.; Ahmed, Saifuddin; Gray, Ronald H.; Paxton, Lynn A.; Wâbwire-Mângen, Fred; Meehan, Mary

doi:10.1016/s0140-6736(98)06439-3

Cited by 680 publications

(433 citation statements)

References 27 publications

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“…The 6-month rate of STDs was 2.29/person-year (95% CI 1.95, 2.63) in the observational group compared to a 6-month STD rate of 1.58/person-year (95% CI 1.29, 1.87) in the metronidazole group which was significantly lower. A comparison of STD rates for the 6-month period following the end of the intervention (months [7][8][9][10][11][12] found no significant differences between the groups. The overall STD rates for the entire 12-month period was 1.64 (95 % CI 1.20, 2.08) in the observational group and 1.31 (95% CI 0.90, 1.72) in the treatment group.…”

Section: Time To Development Of Std and Std Ratesmentioning

confidence: 99%

A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases

Schwebke

Desmond

2007

American Journal of Obstetrics and Gynecology

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Objective-To determine if treatment of BV decrease the incidence of sexually transmitted diseases.Study Design-Women with asymptomatic BV were studied prospectively to determine the effect of treatment of BV for the prevention of STD. Women were randomized to observation or treatment and prophylaxis with intravaginal metronidazole gel. Women were screened monthly for STDs.Results-Women randomized to metronidazole gel had a significantly longer time to development of STD compared to women in the observation group (p=0.02). The 6-month STD rate was 1.58/ person-year (95% CI 1.29, 1.87) for women in the metronidazole gel group versus 2.29/person-year (95% CI 1.95, 2.63) for women in the observational group. The difference in STD rates was driven by a significant difference in the number of chlamydial infections (0.013).Conclusion-Treatment and twice-weekly prophylactic use of intravaginal metronidazole gel resulted in significantly fewer cases of chlamydia.

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Section: Time To Development Of Std and Std Ratesmentioning

confidence: 99%

A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases

Schwebke

Desmond

2007

American Journal of Obstetrics and Gynecology

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“…Prevalenca bakterijske vaginoze, kod žena u reproduktivnom periodu, u SAD je 29% [16], dok je prevalence bakterijske vaginoze u selima Ugande i preko 50% [17]. Naši rezultati su u skladu sa rezultatima onih istraživača koji su upisali učestalost bakterijske vaginoze kod 8-23% žena u reproduktivnom periodu [18][19][20].…”

Section: Diskusijaunclassified

Učestalost i simptomatologija izmijenjene vaginalne flore kod žena na području opštine Foča

Stanković¹,

Mrgud²,

Lukic³

et al. 2017

Biomedicinska istraž.

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Kratak sadržajUvod. Bakterijska vaginoza predstavlja poremećaj u sastavu vaginalne flore u smislu smanjenja broja laktobacila, a predominacije anaerobnih bakterija Gardnerella vaginalis, Atopobium vaginae i Mobiluncus spp. Najčešći simptom udružen sa bakterijskom vaginozom je rijedak, homogen, mliječno bijeli ili sivkast vaginalni sekret, neprijatnog mirisa. Cilj rada je određivanje učestalosti i simptomatologije izmijenjene vaginalne flore kod žena u reproduktivnom periodu iz područja opštine Foča, Republika Srpska. Metode.Ispitivanje je obuhvatilo 100 žena u reproduktivnom periodu, pri čemu trudnice nisu uključene u ovu studiju. Na direktnom preparatu obojenom po Gram-u, koristeći sistem bodovanja po Nugent-u, dijagnostikovana je izmijenjena vaginalna flora. Na osnovu anamnestičkih podataka utvrđivali smo da li se pojedini simptomi češće javljaju u grupi ispitanica sa izmijenjenom vaginalnom florom (bakterijska vaginoza i intermedijerna flora) u odnosu na žene sa normalnom vaginalnom florom.Rezultati. Koristeći sistem bodovanja po Nugent-u bakterijska vaginoza je dijagnostikovana kod 22% ispitanica, intermedijerna flora je nađena kod 18% ispitanica, dok je njih 60% imalo normalnu vaginalnu floru. Kod ispitanica sa dijagnostikovanom bakterijskom vaginozom najčešći simptom je bio pojačan sekret. Obradom podataka utvrđeno je da nema statistički značajne razlike u učestalosti ispitivanih simptoma (pojačan sekret, peckanje, svrab) kod ispitanica sa izmijenjenom vaginalnom florom u odnosu na ispitanice sa normalnom vaginalnom florom. Asimptomatska bakterijska vaginoza je dijagnostikovana kod 4 (18,2%) ispitanice.Zaključak. Izmijenjena vaginalna flora, u vidu bakterijske vaginoze ili intermedijerne flore dijagnostikovana je kod 40% ispitanica. Među ispitanicama sa dijagnostikovanom bakterijskom vaginozom najčešći simptom je bio pojačan sekret ali nisu uočene značajne razlike u učestalosti simptomatoma kod žena sa izmijenjenom vaginalnom florom u odnosu na žene sa normalnom vaginalnom florom.Ključne riječi: bakterijska vaginoza, vaginalni sekret, vaginalna mikroflora

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“…Research conducted with core group populations has helped document the fact that STIs are potent biological cofactors in the sexual transmission of HIV. 34,36,43 However, HIV-preventive interventions targeted at STI control in generalized epidemics 34,44,45 have had dramatically different results, suggesting the need for further specification of the phase of the epidemic to improve understanding of transmission dynamics and the timing of specific interventions. 46 These data suggest that STI control may be only one component of multimethod and multilevel approaches to preventing HIV infection.…”

Section: Understanding Hiv Sexual Transmission In the Context Of Devementioning

confidence: 99%

The Dynamics of Substance Use and Sex Networks in HIV Transmission

Miller

2003

Journal of Urban Health: Bulletin of the New York Academy of Me

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Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial

Cited by 680 publications

References 27 publications

A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases

A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases

Učestalost i simptomatologija izmijenjene vaginalne flore kod žena na području opštine Foča

The Dynamics of Substance Use and Sex Networks in HIV Transmission

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