This article presents the possibility of using of multiple regression analysis (MRA) and dynamic neural network (DNN) for prediction of stability of Hydrocortisone 100 mg (in a form of hydrocortisone sodium succinate) freeze-dried powder for injection packed into a dual chamber container. Degradation products of hydrocortisone sodium succinate: free hydrocortisone and related substances (impurities A, B, C, D and E; unspecified impurities and total impurities) were followed during stress and formal stability studies. All data obtained during stability studies were used for in silico modeling; multiple regression models and dynamic neural networks as well, in order to compare predicted and observed results. High values of coefficient of determination (0.950.99) were gained using MRA and DNN, so both methods are powerful tools for in silico stability studies, but superiority of DNN over mathematical modeling of degradation was also confirmed
SU M M A RYMedical simulation is an artificial and a faithful representation of real clinical situations with the help of static and interactive doll simulators, standardized patients/actors, models for the exercise, simulation on a computer screen and a "serious" performance of a real clinical situation. That is a modern way of learning that helps students and health workers to achieve a higher level of expertise and provide a safer health care. Medical simulation is one of the greatest and most important innovations in medical education for the past 20 years. The goal of the simulation is to provide an optimal relationship between education and patient's safety. It is used both in undergraduate and postgraduate studies, as well as in continuing medical education. Simulators used in medical education can be divided into six groups, ranging from the use of paper and pencils to the most modern computerized interactive simulator. Depending on the economic development level and the organization of health care, rigorous high medical simulation can be performed in three ways: in the center for medical simulation, in the form of "in situ" simulation, and as remote simulations.
Kratak sadržajUvod. Bakterijska vaginoza predstavlja poremećaj u sastavu vaginalne flore u smislu smanjenja broja laktobacila, a predominacije anaerobnih bakterija Gardnerella vaginalis, Atopobium vaginae i Mobiluncus spp. Najčešći simptom udružen sa bakterijskom vaginozom je rijedak, homogen, mliječno bijeli ili sivkast vaginalni sekret, neprijatnog mirisa. Cilj rada je određivanje učestalosti i simptomatologije izmijenjene vaginalne flore kod žena u reproduktivnom periodu iz područja opštine Foča, Republika Srpska. Metode.Ispitivanje je obuhvatilo 100 žena u reproduktivnom periodu, pri čemu trudnice nisu uključene u ovu studiju. Na direktnom preparatu obojenom po Gram-u, koristeći sistem bodovanja po Nugent-u, dijagnostikovana je izmijenjena vaginalna flora. Na osnovu anamnestičkih podataka utvrđivali smo da li se pojedini simptomi češće javljaju u grupi ispitanica sa izmijenjenom vaginalnom florom (bakterijska vaginoza i intermedijerna flora) u odnosu na žene sa normalnom vaginalnom florom.Rezultati. Koristeći sistem bodovanja po Nugent-u bakterijska vaginoza je dijagnostikovana kod 22% ispitanica, intermedijerna flora je nađena kod 18% ispitanica, dok je njih 60% imalo normalnu vaginalnu floru. Kod ispitanica sa dijagnostikovanom bakterijskom vaginozom najčešći simptom je bio pojačan sekret. Obradom podataka utvrđeno je da nema statistički značajne razlike u učestalosti ispitivanih simptoma (pojačan sekret, peckanje, svrab) kod ispitanica sa izmijenjenom vaginalnom florom u odnosu na ispitanice sa normalnom vaginalnom florom. Asimptomatska bakterijska vaginoza je dijagnostikovana kod 4 (18,2%) ispitanice.Zaključak. Izmijenjena vaginalna flora, u vidu bakterijske vaginoze ili intermedijerne flore dijagnostikovana je kod 40% ispitanica. Među ispitanicama sa dijagnostikovanom bakterijskom vaginozom najčešći simptom je bio pojačan sekret ali nisu uočene značajne razlike u učestalosti simptomatoma kod žena sa izmijenjenom vaginalnom florom u odnosu na žene sa normalnom vaginalnom florom.Ključne riječi: bakterijska vaginoza, vaginalni sekret, vaginalna mikroflora
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