Control of Reflex Detrusor Activity in Normal and Spinal Injured Non-human Primates

McGuire, Edward J.; Morrissey, Susan G.; Zhang, Schichun; Horwinski, Elwood R.

doi:10.1016/s0022-5347(17)51982-5

Cited by 43 publications

(26 citation statements)

References 5 publications

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“…These studies (15,25) showed that stimulation frequencies of 0.5-10 Hz acutely suppressed reflex bladder activity. However, the prolonged poststimulation inhibitory effect detected following 20-Hz stimulation in clinical studies (1, 2, 4, 9, 10, 12-14, 16, 18 -20, 23, 28 -31) has not been confirmed in animal studies.…”

mentioning

confidence: 96%

Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats

Tai¹,

Shen

Chen³

et al. 2011

American Journal of Physiology-Renal Physiology

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Inhibition of bladder activity by tibial nerve stimulation was investigated in α-chloralose-anesthetized cats with an intact spinal cord. Short-duration (3-5 min) tibial nerve stimulation at both low (5 Hz) and high (30 Hz) frequencies applied repeatedly during rhythmic isovolumetric bladder contractions was effective in inhibiting reflex bladder activity. Both frequencies of stimulation were also effective in inducing inhibition that persisted after the termination of the stimulation. The poststimulation inhibitory effect induced by the short-duration stimulation significantly increased bladder capacity to 181.6 ± 24.36% of the control capacity measured before applying the stimulation. Thirty-minute continuous stimulation induced prolonged poststimulation inhibition of bladder activity, which lasted for more than 2 h and significantly increased bladder capacity to 161.1 ± 2.9% of the control capacity. During the poststimulation periods, 5-Hz stimulation applied during the cystometrogram elicited a further increase (~30% on average) in bladder capacity, but 30-Hz stimulation was ineffective. These results in cats support the clinical observation that tibial nerve neuromodulation induces a long-lasting poststimulation inhibitory effect that is useful in treating overactive bladder symptoms.

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mentioning

confidence: 96%

Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats

Tai¹,

Shen

Chen³

et al. 2011

American Journal of Physiology-Renal Physiology

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“…Percutaneous tibial nerve stimulation (PTNS) had its beginnings more than 25 years ago, as described by McGuire and colleagues [16]. Capitanucci et al [17•] described their experience with PTNS in pediatric patients with different lower urinary tract dysfunction, including seven with neurogenic bladder resistant to conventional therapy.…”

Section: Electrical Bladder Stimulationmentioning

confidence: 99%

Conservative Nonsurgical Management of Spina Bifida

Carr

2010

Curr Urol Rep

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The nonsurgical management of patients with spina bifida is predicated on maintaining a compliant bladder of adequate size or correcting detrusor sphincter dyssynergy that can lead to progressive bladder damage and ultimately upper tract changes. Pharmacologic management, targeted at the detrusor and/or external sphincter, can be done. Neuromodulation using transcutaneous approaches with interferential electrostimulation, sacral (S2-S3) via digital transcutaneous electrical nerve stimulation, and percutaneous tibial nerve stimulation all have shown varied successes.

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“…Stimulation of the tibial nerve has first been described as a neuromodulatory treatment option by McGuire et al [28] in 1983. By stimulating the tibial nerve at the site of the medial malleolus of the ankle, detrusor activity could be suppressed in normal and spinal injured non-human primates.…”

Section: Tibial Nerve Stimulationmentioning

confidence: 99%

“…Animal studies have shown that stimulation of the external urethral sphincter, through peripheral nerves (i.e. pudendal nerve and tibial nerve), results in inhibition of detrusor activity [1] .…”

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confidence: 99%

Applications of Neurostimulation for Urinary Storage and Voiding Dysfunction in Neurological Patients

Rey

Heesakkers²

2008

Urol Int

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The application of various forms of electrical stimulation is considered a therapeutic option to manage different types of lower urinary tract dysfunction. However, even though lower urinary tract dysfunction is common in patients with neurological disease, apart from patients with spinal cord injury, electrostimulation is still not widely applied in a neurological patient population. Urologists frequently encounter patients with neurogenic lower urinary tract dysfunction in their daily practice. Often, the conservative treatment modalities do not offer adequate relief of symptoms in these patients. In most cases, surgical options including transurethral stents, augmentation cystoplasty stoma or derivation surgery are considered a last resort. With this in mind, it is essential that healthcare professionals are informed about the possibilities of nerve stimulation in neurogenic patients. We review the utilization and the results of electrical stimulation by means of pudendal nerve stimulation, stimulation of the sacral nerve roots and lower limb stimulation in patients with neurogenic detrusor overactivity.

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Control of Reflex Detrusor Activity in Normal and Spinal Injured Non-human Primates

Cited by 43 publications

References 5 publications

Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats

Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats

Conservative Nonsurgical Management of Spina Bifida

Applications of Neurostimulation for Urinary Storage and Voiding Dysfunction in Neurological Patients

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