Control of programmed cell death by neurotransmitters and neuropeptides in the developing mammalian retina

Linden, Rafael; Martins, Rodrigo A. P.; Silveira, Mariana S.

doi:10.1016/j.preteyeres.2004.10.001

Cited by 43 publications

(27 citation statements)

References 528 publications

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“…The role of apoptosis in remodelling processes of the retina until day P14 is a well established mechanism (Smith et al 2002;Linden et al 2005;Marigo 2007). It is important, however, that only overexpression of the full-length protein harboring a mitochondrial targeting sequence is capable of inducing apoptosis (Lv et al 2006).…”

Section: Retinal Developmentmentioning

confidence: 99%

Expression of PTPIP51 during mouse eye development

Maerker

Schreiner

Tag

et al. 2007

Histochem Cell Biol

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The expression pattern of the novel tyrosine phosphatase interacting protein 51 (PTPIP51) was studied during the organogenesis of mouse eye on a transcriptional (RT-PCR and in situ hybridization) and translational level (immunohistochemistry and immunoblotting). Timed developmental stages from day E12 to day E18 were analyzed regarding the distribution of PTPIP51 and compared to the expression patterns observed during postnatal developmental stages and adult eye. PTPIP51 was found to be expressed in all investigated developmental stages in derivatives of mesoderm and ectoderm, such as developing cornea, lens, neuroretina and extraocular muscles. Conjuctiva and corneal epithelia were PTPIP51 reactive during all investigated developmental stages including the mature eye. Embryonic differentiation led to reactive keratocytes of the corneal stroma and remained so in post partal stages, as well as in the adult eye. On day E12, all cells comprising the developing lens body showed PTPIP51 expression. Further development unto the adult eye resulted in a restriction of PTPIP51 expression to the anterior lens epithelium and finally to the equatorial region of the lens epithelium. The developing neuroretina showed a strong PTPIP51 expression in the inner neuroblastic layer and the future receptor cell layer. In the adult eye, the retinal ganglion cells and the inner nuclear layer remained PTPIP51 reactive. The data presented here suggests PTPIP51 to be integrated in signaling cascades regulating differentiation and apoptosis during eye development.

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Section: Retinal Developmentmentioning

confidence: 99%

Expression of PTPIP51 during mouse eye development

Maerker

Schreiner

Tag

et al. 2007

Histochem Cell Biol

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“…In the mouse retina, apoptotic cells are found prenatally in the early neuroblastic layer and within the developing nuclear layers as these emerge postnatally (Péquignot et al, 2003; Young, 1984). The latter wave of programmed cell death has been associated with the period of synaptogenesis as the various types of retinal neurons establish their connectivity with afferents and targets, and may indicate an intercellular dependency with those synaptic partners (Linden, 2000; Linden et al, 2005). This programmed cell death is modulated by the Bcl-2 family of regulatory proteins controlling apoptosis, for when the pro-apoptotic gene, Bax , is knocked out, the frequency of dying cells during development is decreased (Mosinger-Ogilvie et al, 1998; Péquignot et al, 2003), and in maturity, the retinal architecture is conspicuously altered.…”

Section: Introductionmentioning

confidence: 99%

Programmed cell death of retinal cone bipolar cells is independent of afferent or target control

Keeley

Madsen

John

et al. 2014

Developmental Biology

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Programmed cell death contributes to the histogenesis of the nervous system, and is believed to be modulated through the sustaining effects of afferents and targets during the period of synaptogenesis. Cone bipolar cells undergo programmed cell death during development, and we confirm that the numbers of three different types are increased when the pro-apoptotic Bax gene is knocked out. When their cone afferents are selectively eliminated, or when the population of retinal ganglion cells is increased, however, cone bipolar cell number remains unchanged. Programmed cell death of the cone bipolar cell populations, therefore, may be modulated cell-intrinsically rather than via interactions with these synaptic partners.

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“…On the other hand, light of mild intensity, such as that used in our study, probably does not lead to any substantial retinal damage. It is possible that the narrow developmental window of cfos and Per1 sensitivity within the RPE is related to programmed cell death during normal neurogenesis (Linden et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Expression and light sensitivity of clock genes Per1 and Per2 and immediate‐early gene c‐fos within the retina of early postnatal Wistar rats

Matějů

Sumová

Bendová

2010

J of Comparative Neurology

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Mammalian retina contains a circadian clock that is composed of components similar to those of the master circadian clock within the suprachiasmatic nuclei of the hypothalamus. The aim of the present study was to elucidate whether, when, and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn rat retina. At postnatal day 1 (P1), P3, P5, and P10, Wistar rat pups were released into constant darkness, and a 30-minute light pulse was administered during the subjective day or during the first or second part of subjective night. Gene expression was determined 30 minutes, 1 hour, 2 hours, and 4 hours after the light pulse by in situ hybridization followed by emulsion autoradiography. Endogenous expression of Per1 was detected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from P1. Until P5, the cells were localized in the dorsal part of the retina, but, at P10, they were already distributed across the entire retinal circumference. Light pulses also induced the expression of c-fos and Per1 in the retinal pigment epithelium until P3, but not afterward. Expression of the Per2 gene was not photoresponsive until P10. These data demonstrate that the rat retina is light-sensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually.

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Control of programmed cell death by neurotransmitters and neuropeptides in the developing mammalian retina

Cited by 43 publications

References 528 publications

Expression of PTPIP51 during mouse eye development

Expression of PTPIP51 during mouse eye development

Programmed cell death of retinal cone bipolar cells is independent of afferent or target control

Expression and light sensitivity of clock genes Per1 and Per2 and immediate‐early gene c‐fos within the retina of early postnatal Wistar rats

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