Control of Maintenance and Regeneration of Planarian Eyes by<i>ovo</i>

Cross, Samuel D.; Johnson, Adiv A.; Gilles, Benjamin; Bachman, Lori A.; Inoue, Takeshi; Agata, Kiyokazu; Marmorstein, Lihua Y.; Marmorstein, Alan D.

doi:10.1167/iovs.15-17458

Cited by 11 publications

(7 citation statements)

References 24 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Reprinted with permission from: Smed-th and NPF (Ref function of conserved transcription factors eyes absent, sine oculis, ovo and six-1/2. 72,[124][125][126][127] Given that dozens of different neuronal cell types have been identified, much remains to be learned about the mechanisms regulating neurogenesis in planarians. Application of single cell sequencing technology has expanded our ability to identify neoblast subclasses and to begin resolving stem cell lineages.…”

Section: Signaling Factors Involved In Brain Inductionmentioning

confidence: 99%

Nervous system development and regeneration in freshwater planarians

Ross

Currie

Pearson

et al. 2017

WIREs Developmental Biology

View full text Add to dashboard Cite

Planarians have a long history in the fields of developmental and regenerative biology. These animals have also sparked interest in neuroscience due to their neuroanatomy, spectrum of simple behaviors, and especially, their almost unparalleled ability to generate new neurons after any type of injury. Research in adult planarians has revealed that neuronal subtypes homologous to those found in vertebrates are generated from stem cells throughout their lives. This feat is recapitulated after head amputation, wherein animals are capable of regenerating whole brains and regaining complete neural function. In this review, we summarize early studies on the anatomy and function of the planarian nervous system and discuss our present knowledge of the molecular mechanisms governing neurogenesis in planarians. Modern studies demonstrate that the transcriptional programs underlying neuronal specification are conserved in these remarkable organisms. Thus, planarians are outstanding models to investigate questions about how stem cells can replace neurons in vivo. WIREs Dev Biol 2017, 6:e266. doi: 10.1002/wdev.266 For further resources related to this article, please visit the WIREs website.

show abstract

Section: Signaling Factors Involved In Brain Inductionmentioning

confidence: 99%

Nervous system development and regeneration in freshwater planarians

Ross

Currie

Pearson

et al. 2017

WIREs Developmental Biology

View full text Add to dashboard Cite

show abstract

“…Because β-arrestin is enriched in the optic nerve as well as in the retina (Figs 3A, 4C;Cross et al, 2015), we exploited the immunoreactivity of β-arrestin to visualize and trace the visual input pathway in L. valentianus. Neurobiotin, a tracer molecule, was incorporated afferently from the cut end of the optic nerve, and the brain sections were stained with anti-β-arrestin antibody to see whether the commissural fiber that incorporated neurobiotin (Matsuo et al, 2014b) is a branch of the optic nerve.…”

Section: Co-localization Of β-Arrestin and Rhodopsin In The Rhabdomermentioning

confidence: 99%

“…β-Arrestin is a good candidate to serve this role. Indeed, the optic nerves have previously been visualized by immunohistochemical staining of this protein in planaria because β-arrestin protein is enriched in the photoreceptor cells and optic nerves in this species (Cross et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Expression and light-dependent translocation of β-arrestin in the visual system of the terrestrial slug Limax valentianus

Matsuo

Takatori

Hamada

et al. 2017

Journal of Experimental Biology

View full text Add to dashboard Cite

Vertebrates, cephalopods and arthropods are equipped with eyes that have the highest spatiotemporal resolution among the animal phyla. In parallel, only animals in these three phyla have visual arrestin specialized for the termination of visual signaling triggered by opsin, in addition to ubiquitously expressed β-arrestin that serves in terminating general G protein-coupled receptor signaling. Indeed, visual arrestin in and rodents translocates to the opsin-rich subcellular region in response to light to reduce the overall sensitivity of photoreceptors in an illuminated environment (i.e. light adaptation). We thus hypothesized that, during evolution, visual arrestin has taken over the role of β-arrestin in those animals with eyes of high spatiotemporal resolution. If this is true, it is expected that β-arrestin plays a role similar to visual arrestin in those animals with low-resolution eyes. In the present study, we focused on the terrestrial mollusk, a species related to cephalopods but that has only β-arrestin, and generated antibodies against β-arrestin. We found that β-arrestin is highly expressed in photosensory neurons, and translocates into the microvilli of the rhabdomere within 30 min in response to short wavelength light (400 nm), to which the eye exhibits a robust response. These observations suggest that β-arrestin functions in the visual system of those animals that do not have visual arrestin. We also exploited anti-β-arrestin antibody to visualize the optic nerve projecting to the brain, and demonstrated its usefulness for tracing a visual ascending pathway.

show abstract

“…They are found throughout the animal kingdom and have been identified in virtually every organism studied (Hartzell et al, 2008; Milenkovic et al, 2008). These diverse bestrophin-containing organisms range in complexity from simple bacteria (Yang et al, 2014), to eye-regenerating planarian flatworms (Cross et al, 2015; Lapan and Reddien, 2012), and finally to complex mammals (Bakall et al, 2003; Marmorstein et al, 2000). Although each bestrophin possesses unique physiological functions, they are invariably ion channels (Hartzell et al, 2008; Xiao et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Bestrophin 1 and retinal disease

Johnson

Guziewicz

Lee

et al. 2017

Progress in Retinal and Eye Research

Self Cite

192

177

View full text Add to dashboard Cite

Mutations in the gene BEST1 are causally associated with as many as five clinically distinct retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies”. These five associated diseases are: Best vitelliform macular dystrophy, autosomal recessive bestrophinopathy, adult-onset vitelliform macular dystrophy, autosomal dominant vitreoretinochoroidopathy, and retinitis pigmentosa. The most common of these is Best vitelliform macular dystrophy. Bestrophin 1 (Best1), the protein encoded by the gene BEST1, has been the subject of a great deal of research since it was first identified nearly two decades ago. Today we know that Best1 functions as both a pentameric anion channel and a regulator of intracellular Ca2+ signaling. Best1 is an integral membrane protein which, within the eye, is uniquely expressed in the retinal pigment epithelium where it predominantly localizes to the basolateral plasma membrane. Within the brain, Best1 expression has been documented in both glial cells and astrocytes where it functions in both tonic GABA release and glutamate transport. The crystal structure of Best1 has revealed critical information about how Best1 functions as an ion channel and how Ca2+ regulates that function. Studies using animal models have led to critical insights into the physiological roles of Best1 and advances in stem cell technology have allowed for the development of patient-derived, “disease in a dish” models. In this article we review our knowledge of Best1 and discuss prospects for near-term clinical trials to test therapies for the bestrophinopathies, a currently incurable and untreatable set of diseases.

show abstract

Control of Maintenance and Regeneration of Planarian Eyes byovo

Abstract: S. mediterranea have the ability to generate functional eyes in the absence of a wound healing response. This ability requires the expression of ovo.

Cited by 11 publications

References 24 publications

Nervous system development and regeneration in freshwater planarians

Nervous system development and regeneration in freshwater planarians

Expression and light-dependent translocation of β-arrestin in the visual system of the terrestrial slug Limax valentianus

Bestrophin 1 and retinal disease

Contact Info

Product

Resources

About