Control of Hemorrhagic Condition in Chickens with Menadione Sodium Bisulfite

Relative Vitamin K Potency of Two Water-Soluble Menadione Analogues

“…used as a source of vitamin K in poultry feeds. This form differs in its vitamin K activity from the fat-soluble menadione (Frost and Spruth, 1955). The data presented in this report indicate that this difference is not necessarily a function, or, at least, not only a function of the change in solubility status, since another watersoluble form of menadione, namely, menadione dimethyl pyrimidinol bisulfite, 2 differs in its activity from menadione sodium bisulfite.…”

On the Vitamin K Requirement of Turkey Poults ,

“…diet by the National Research Council (1954). Frost and Spruth (1955) also believe that 0.09 mg. of MSB per pound of feed will support normal clotting time, while 0.18 mg. of menadione failed to give normal prothrombin levels in chicks (Frost et al, 1956). for menadione sodium bisulfite (MSB).…”

Factors Affecting the Vitamin K Requirement of the Chick

“…Vitamin Ki and synthetic analogues of vitamin K reduced the blood clotting time of these chicks to normal but no reduction in the incidence of lesions occurred. Frost and Spruth (1955) obtained evidence that 0.1% sulfaquinoxaline increased the vitamin K requirement of the chick many times, whereas 0.03% sulfaquinoxaline had little effect. Griminger et al (1953) obtained evidence that oxytetracycline (terramycin) and 3-nitro-4-hydroxyphenyl arsonic acid (arsonic acid) significantly prolonged the blood clotting time of chicks and the effect of p-aminophenylarsonic acid (arsanilic acid) was almost significant.…”