Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis

Hu, Bing; Lefort, Karine; Qiu, Wenying; Nguyen, Bach Cuc; Rajaram, R; Castillo, Einar; He, Fenglei; Chen, Yiping; Angel, Peter; Brisken, Cathrin; Dotto, G. Paolo

doi:10.1101/gad.1886910

Cited by 94 publications

(105 citation statements)

References 53 publications

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“…Consistent with this notion, Notch3 and Notch4 are expressed in the pancreatic mesenchyme during pancreas budding (Lammert et al, 2000;Jensen et al, 2000b). Such distinct epithelium/mesenchyme Notch functions were recently reported to control hair follicle differentiation (Hu et al, 2010).…”

Section: Notch Signaling In Early Pancreatic Progenitor Developmentsupporting

confidence: 57%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

524

594

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Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell-types in vivo, and to the optimization of the forward-directed-differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature b-cells. Developmental Dynamics 240:530-565,

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Section: Notch Signaling In Early Pancreatic Progenitor Developmentsupporting

confidence: 57%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

524

594

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“…Elimination of dermal Wnt ligand secretion did not alter Wnt responsiveness or Col1a1 mRNA expression in the upper dermis, innervation, vasculature formation, epidermis stratification or embryonic hair follicle development. Dermal Wnt5a-deficient mouse skin shows hair follicle differentiation defects starting 1 week after grafting on nude mice (Hu et al, 2010). However, mutant mice do not survive postnatally, which prevents further investigation of late stage hair follicle differentiation and renewal.…”

Section: Discussionmentioning

confidence: 99%

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

et al. 2012

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SUMMARYDermal fibroblasts are required for structural integrity of the skin and for hair follicle development. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. We show in mice that epidermal Wnt ligands are required for uniform dermal Wnt signaling/-catenin activity and regulate fibroblast cell proliferation and initiation of hair follicle placodes. In the absence of dermal Wnt signaling/-catenin activity, patterned upregulation of epidermal -catenin activity and Edar expression are absent. Conversely, forced activation of -catenin signaling leads to the formation of thickened dermis, enlarged epidermal placodes and dermal condensates that result in prematurely differentiated enlarged hair follicles. These data reveal functional roles for dermal Wnt signaling/-catenin in fibroblast proliferation and in the epidermal hair follicle initiation program.

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“…Notch signalling is known to play a unique function in the control of hair follicle differentiation by modulation of Foxn1 (Hu et al, 2010). Although hair is an epidermal appendage that arose after the last shared common ancestor between mammals and birds, embryonic chicken feathers and nails also express Foxn1, demonstrating the conservation of these developmental processes during evolution (Darnell et al, 2014).…”

Section: Thymic Rudimentmentioning

confidence: 99%

Notch and Hedgehog in the thymus/parathyroid common primordium: Crosstalk in organ formation

Figueiredo

Silva

Santos

et al. 2016

Developmental Biology

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Neves, Notch and Hedgehog in the thymus/parathyroid common primordium: Crosstalk in organ f o r m a t i o n , Developmental Biology, http://dx.doi.org/10. 1016/j.ydbio.2016.08.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThe avian thymus and parathyroids (T/PT) common primordium derives from the endoderm of the third and fourth pharyngeal pouches (3/4PP). The molecular mechanisms that govern T/PT development are not fully understood. Here we study the effects of Notch and Hedgehog (Hh) signalling modulation during common primordium development using in vitro, in vivo and in ovo approaches. The impairment of Notch activity reduced Foxn1/thymus-fated and Gcm2/Pth/parathyroid-fated domains in the 3/4PP and further compromised the development of the parathyroid glands. When Hh signalling was abolished, we observed a reduction in the Gata3/Gcm2-and Lfng-expression domains at the median/anterior and median/posterior territories of the pouches, respectively. In contrast, the Foxn1 expression- This study offers novel evidence on the role of Notch signalling in T/PT common primordium development, in an Hh-dependent manner.

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Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis

Cited by 94 publications

References 53 publications

Pancreas organogenesis: From bud to plexus to gland

Pancreas organogenesis: From bud to plexus to gland

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

Notch and Hedgehog in the thymus/parathyroid common primordium: Crosstalk in organ formation

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