Control of Gastric Acidity in Peptic Ulcer

Nicol, B. M.

doi:10.1016/s0140-6736(00)62961-6

Cited by 22 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3). These results confirm Nicol's (1939) observation that oral atropine 0-6 mg every four hours does not decrease intragastric acidity and they are compatible with those of Kirsner and Palmer (1940) who found no effect on intragastric acidity when they gave atropine 1-0 mg four times during the day. The results of this study do not support the report of Mitchell et al (1962) that a mean single oral dose of atropine 0-8 mg can decrease postprandial intragastric acidity by approximately 40%.…”

Section: Discussionsupporting

confidence: 91%

24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

Pounder¹,

Hunt²,

Vincent³

et al. 1977

Gut

View full text Add to dashboard Cite

SUMMARY Cimetidine markedly inhibits gastric acid secretion, but from the therapeutic point of view it is important to know whether concurrent treatment with an anticholinergic increases its effect. This possibility has been investigated by measuring the 24 h intragastric acidity and nocturnal output of acid in four duodenal ulcer patients, each receiving on separate occasions cimetidine 1 g/day and placebo, atropine 2-4 mg/day and placebo, cimetidine and atropine, or two placebos.Cimetidine alone decreased mean hourly hydrogen ion activity by 63 % of control values, decreased mean hourly hydrogen ion concentration (total acid) by 41 %, inhibited nocturnal acid secretion by 830% and resulted in half the nocturnal samples being anacidic. Atropine alone had no effect when compared with control and combined treatment with both drugs was not superior to cimetidine alone. Atropine did not affect the absorption or urinary excretion of cimetidine. Fasting serum gastrin concentrations were not changed by any of the treatments.At the doses studied, the combination of cimetidine with an anticholinergic appears to offer no advantages over treatment with the H2-antagonist alone. Cimetidine is the only potent anti-secretory drug that does not cause acute side-effects and this important advantage would be lost if it were given with a maximal dose of an anticholinergic.There is experimental and clinical evidence to suggest that the actions of a histamine H2-receptor antagonist and an anticholinergic might be additive or even synergistic (Thjodleifsson and Wormsley, 1974;Richardson et al., 1975;Thompson et al., 1975;Richardson and Walsh, 1976).The object of the present study was to determine whether combined treatment with cimetidine and an anticholinergic is likely to be more effective than either drug alone. MethodsFour male patients, weighing 62-3, 85-5, 85-9 and 85 9 kg and aged 33, 19, 21 and 24 years respectively, were studied for 24 h periods on the same days of 'Reprint requests:

show abstract

Section: Discussionsupporting

confidence: 91%

24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

Pounder¹,

Hunt²,

Vincent³

et al. 1977

Gut

View full text Add to dashboard Cite

show abstract

“…Both drugs used in this study causc reduction in gastric acid secretion in n case of glycopyrronium, this has been basal (Moeller, 1962;Posey, 1962;Abbo Krieger, and Levey, 1962;Sun, 1962), (Barman and Larson, 1963) (Nicol, 1939;Lennard-Jones, 1961;Hogan, 1964). In this study, basal secretion was co 30 minutes.…”

Section: Discussionmentioning

confidence: 88%

Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs

Kaye¹,

Beck²,

Rhodes³

et al. 1969

Gut

View full text Add to dashboard Cite

SUMMARY Ninety patients with duodenal ulcer, divided randomly into three groups, were treated continuously for one year with either glycopyrronium, 1-hyoscyamine (as a sustained-release preparation) or inert tablets. Dosage with active tablets was so adjusted that the patient experienced definite but tolerable side-effects. Basal and maximal gastric acid secretion were measured immediately before and one week after cessation of treatment. There was no significant change in the means of these measurements in patients who received placebo or 1-hyoscyamine. In Wales, 1966) it was stated that reduced levels of acid secretion persisted for up to 30 months after the drug had been stopped. This maintained reduction was thought to reflect the course of the underlying disorder rather than a direct effect of the anticholinergic drug.In this report, we describe our findings in a group of 90 patients with duodenal ulcer who were treated continuously for one year with anticholinergic drugs. PATIENTS AND METHODSAll patients were male, had a duodenal ulcer recently demonstrated by radiograph, and had had symptoms within six months of the first examination. They were taking part in a trial of long-term anticholinergic therapy, full details of which will be published shortly, and were allocated randomly to one of three groups.

show abstract

“…Wosika and Emery (1935) elaborated this work and demonstrated that the acidity was lower when patients took six feeds daily, with hourly milk and cream, than when they took milk-cream alone at the beginning of treatment, or three feeds daily later in treatment. Nicol (1939), in an excellent study, found similar results in that the mean acidity of gastric samples was greater when patients took an 'hourly' diet (5 oz. milk + 1 oz.…”

Section: Difference Between Corresponding Ph Valuesmentioning

confidence: 65%

“…Several previous authors have shown that the acidity of the gastric contents tends to be lower when patients take food than when they take repeated drinks of a milk-cream mixture (Nicol, 1939;Kirsner and Palmer, 1940;Bingle and Lennard-Jones, 1960). These findings must be interpreted cautiously because there is a transitory fall in acidity after each drink which is not detected if gastric samples are withdrawn one hour later (Levy, 1950;Bingle and Lennard-Jones, 1960).…”

Section: Difference Between Corresponding Ph Valuesmentioning

confidence: 96%

Effect of different foods on the acidity of the gastric contents in patients with duodenal ulcer: Part I A comparison between two `therapeutic' diets and freely-chosen meals

Lennard-Jones¹,

Babouris²

1965

Gut

View full text Add to dashboard Cite

Control of Gastric Acidity in Peptic Ulcer

Cited by 22 publications

References 0 publications

24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs

Effect of different foods on the acidity of the gastric contents in patients with duodenal ulcer: Part I A comparison between two `therapeutic' diets and freely-chosen meals

Contact Info

Product

Resources

About