Control of expired CO2 level and minute-ventilation during a hyperventilation challenge for asthmatics

Mussell, M. J.

doi:10.1016/0141-5425(86)90086-5

Journal of Biomedical Engineering

1986

DOI: 10.1016/0141-5425(86)90086-5

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Control of expired CO2 level and minute-ventilation during a hyperventilation challenge for asthmatics

M. J. Mussell

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1988

1989

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Cited by 2 publications

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“…However, there is a time delay between changing the inspired air Pco2, and a change being registered in PETco2, which makes the system potentially unstable. Previous workers (WARD et al, 1974;MUSSELL, 1986) demonstrated that a proportional-integral (PI) controller (Fig. 1 b) is sufficient to stabilize such a system-the integrator holds the set point between breaths and reduces steady-state errors, while the proportional gain is responsible for a sharp initial transient.…”

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confidence: 99%

A new CO2 inhalation system for studying regulation of breathing.

1989

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Summary This paper describes the development of a computercontrolled system that controls inspired C02 or end-tidal Pco2 (PETco2) to follow preprogrammed functions such as step, sinusoid, and pulse, under normoxic, hyperoxic, and hypoxic conditions. The system uses a proportional-integral (PI) controller that was optimized by adjusting the PI parameters so as to minimize the integral-time of absolute error (ITAE) performance parameter.

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confidence: 99%

A new CO2 inhalation system for studying regulation of breathing.

1989

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Trachea-noise biofeedback in asthma: A comparison of the effect of trachea-noise biofeedback, a bronchodilator, and no treatment on the rate of recovery from exercise- and eucapnic hyperventilation-induced asthma

Mussell

Hartley

1988

Biofeedback and Self-Regulation

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We review some of the evidence that supports the existence of psychosomatic triggers to bronchospasm in asthmatics, and hypothesize that it may also be possible to consciously reverse bronchospasm using trachea-noise biofeedback. We precipitated significant levels of bronchospasm in 16 asthmatics using exercise or eucapnic-hyperventilation challenges on five occasions, and administered four different treatments and a no-treatment control. The treatments were trachea-noise biofeedback (TNBF), wrong-information TNBF, an inhaled adrenergic bronchodilator, and a placebo inhaler, all given double blind. Half of the subjects had 3 training days in the use of the TNBF device before study. Our results show that TNBF, in the trained subjects only, is associated with a detectable, but not statistically significant, increase in the rate of recovery from bronchospasm over that found with no treatment. We conclude that, although asthmatics seem to have a strong ability to consciously induce bronchospasm, conscious reversal of a full asthma attack using TNBF is limited. Despite contrary conclusions by other investigators, we believe that this study demonstrated little TNBF-assisted recovery from bronchospasm. We suggest that this is because its effect may be inhibited by humoral mechanisms that sustain the attack, but we believe further work is required to support this.

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Control of expired CO2 level and minute-ventilation during a hyperventilation challenge for asthmatics

Cited by 2 publications

References 13 publications

A new CO2 inhalation system for studying regulation of breathing.

A new CO2 inhalation system for studying regulation of breathing.

Trachea-noise biofeedback in asthma: A comparison of the effect of trachea-noise biofeedback, a bronchodilator, and no treatment on the rate of recovery from exercise- and eucapnic hyperventilation-induced asthma

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