A new CO2 inhalation system for studying regulation of breathing.

Abstract

Summary This paper describes the development of a computercontrolled system that controls inspired C02 or end-tidal Pco2 (PETco2) to follow preprogrammed functions such as step, sinusoid, and pulse, under normoxic, hyperoxic, and hypoxic conditions. The system uses a proportional-integral (PI) controller that was optimized by adjusting the PI parameters so as to minimize the integral-time of absolute error (ITAE) performance parameter.