Control of epileptic seizures by electrical stimulation: a model-based study

Abstract

High frequency electrical stimulation of brain is commonly used in research experiments and clinical trials as a modern tool for control of epileptic seizures. However, the mechanistic basis by which periodic external stimuli alter the brain state is not well understood. This study provides a computational insight into the mechanism of seizure suppression by high frequency stimulation (HFS). In particular, a modified version of the Jansen-Rit neural mass model is employed, in which EEG signals can be considered as the input. The proposed model reproduces seizure-like activity in the output during the ictal period of the input signal. By applying a control signal to the model, a wide range of stimulation amplitudes and frequencies are systematically explored. Simulation results reveal that HFS can effectively suppress the seizure-like activity. Our results suggest that HFS has the ability of shifting the operating state of neural populations away from a critical condition. Furthermore, a closed-loop control strategy is proposed in this paper. The main objective has been to considerably reduce the control effort needed for blocking abnormal activity of the brain. Such an energy reduction could be of practical importance, to reduce possible side effects and increase battery life for implanted neurostimulators.

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“…Electrical stimulation applied at the sensory or motor threshold is suggested to modulate neuronal activity. This has shown potential clinical applications such as pain relief control of epileptic seizures [ 1 ], muscle activation [ 2 , 3 ], relief of symptoms of Parkinson’s disease [ 4 ], improvement of motor function after a stroke [ 5 , 6 ], and spasticity control [ 7 ], as well as the diagnosis of neural injuries [ 8 ].…”