Regulating absence seizures by tri-phase delay stimulation applied to globus pallidus internal

Abstract

In this paper, a reduced globus pallidus internal (GPI)-corticothalamic (GCT) model is developed, and a tri-phase delay stimulation (TPDS) with sequentially applying three pulses on the GPI representing the inputs from the striatal D 1 neurons, subthalamic nucleus (STN), and globus pallidus external (GPE), respectively, is proposed. The GPI is evidenced to control absence seizures characterized by 2 Hz-4 Hz spike and wave discharge (SWD). Hence, based on the basal ganglia-thalamocortical (BGCT) model, we firstly explore the triple effects of D l -GPI, GPE-GPI, and STN-GPI pathways on seizure patterns. Then, using the GCT model, we apply the TPDS on the GPI to potentially investigate the alternative and improved approach if these pathways to the GPI are blocked. The results show that the striatum D 1 , GPE, and STN can indeed jointly and significantly affect seizure patterns. In particular, the TPDS can effectively reproduce the seizure pattern if the D 1 -GPI, GPE-GPI, and STN-GPI pathways are cut off. In addition, the seizure abatement can be obtained by well tuning the TPDS stimulation parameters. This implies that the TPDS can play the surrogate role similar to the modulation of basal ganglia, which hopefully can be helpful for the development of the brain-computer interface in the clinical application of epilepsy.

Improved control effect of pathological oscillations by using delayed feedback stimulation in neural mass model with pedunculopontine nucleus

“…Many researchers suggested that stimulation targeting subthalamic nucleus (STN) and globus pallidus interna (GPi) (Hou et al., 2022) can improve the motor symptoms of patients. However, they usually ignore the role of globus pallidus (GPe) in the central brain region of the basal ganglia, and stimulating GPe may have a similar effect.…”

Dynamic modeling of neuromodulation techniques: Towards elaboration and individual specificity

“…Based on the mean-field model, DBS is simulated as the applied electric field generated by the stimulation electrode (fig. 1(a)) [19][20][21][22][23]. The specific modeling method is shown in the following two equations:…”

“…φ DBS is the input pulse that stimulates an electric field generated by an electrode. This modeling method is used to explore the effect of DBS on absence epilepsy, focusing on the modulation effect of external stimulation on spike and slow-wave discharges [21][22][23]. Wang et al investigated the impact of coordinated reset stimulation (CRS), which involves intermittent pulsed currents applied to the cortex, specific relay nucleus (SRN), and thalamic reticular nucleus (TRN), on the control of absence seizures using a cortical-thalamic mean-field model [21].…”