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Cited by 6 publications
(4 citation statements)
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“…Of course, there must be a limit to this homeostatic mechanism, which is related to the maximal lymph flow rate and the minimal interstitial COP. This was illustrated in experi ments where dogs were progressively protein depleted by plasmapheresis [78]. While plasma protein concentration was reduced from 7.0 to 4.5 g/1, BV was preserved, and a decrease of BV was seen (together with sodium retention) when protein was further lowered to 2.5 g/l.…”
Section: Regulation Of the Bv During Hypoproteinemiamentioning
confidence: 96%
See 1 more Smart Citation
“…Of course, there must be a limit to this homeostatic mechanism, which is related to the maximal lymph flow rate and the minimal interstitial COP. This was illustrated in experi ments where dogs were progressively protein depleted by plasmapheresis [78]. While plasma protein concentration was reduced from 7.0 to 4.5 g/1, BV was preserved, and a decrease of BV was seen (together with sodium retention) when protein was further lowered to 2.5 g/l.…”
Section: Regulation Of the Bv During Hypoproteinemiamentioning
confidence: 96%
“…For a more general discussion, the reader is referred to recent excellent reviews [48,49,77,78,111], Acute reduction of plasma proteins leads to decreased colloid osmotic pressure (COP) of the plasma and loss of fluid from the vascular compartment. The resulting de crease in circulating volume will, by mechanisms as yet incompletely understood [100], induce the kidney to retain sodium and water.…”
Section: Regulation Of the Bv During Hypoproteinemiamentioning
confidence: 99%
“…77 The kidney primarily modifies sodium balance in response to ECBV derangements. 78-80 While the kidney's set point focuses on the vascular compartment, its homeostatic response affects the entire ECF as sodium distributes throughout this compartment. Thus, only the vascular compartment is actively regulated, while homeostasis of the significantly larger extravascular ECF, particularly the interstitium, depends primarily on local autoregulation.…”
Section: Extracellular Fluid Dynamicsmentioning
confidence: 99%
“…Thus, only the vascular compartment is actively regulated, while homeostasis of the significantly larger extravascular ECF, particularly the interstitium, depends primarily on local autoregulation. 81, 80 …”
Section: Extracellular Fluid Dynamicsmentioning
confidence: 99%