Control of Aspirin Effect in Chronic Cardiovascular Patients Using two Whole Blood Platelet Function Assays: PFA-100 and Multiple Electrode Aggregometry

Assessment of platelet function by whole blood impedance aggregometry in coronary artery bypass grafting patients on acetylsalicylic acid treatment may prompt a switch to dual antiplatelet therapy

“…Similar results, although with different anticoagulant used for blood sampling for MEA were also described [15,16]. …”

Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry

“…15 To date, MEA has proven sensitive for platelet inhibition induced by aspirin and clopidogrel, as well as for the effects of cardiopulmonary bypass (CPB) and of hypothermia on platelet aggregation. 14,[16][17][18] MEA usefulness in identifying groups of patients at a high risk of transfusion of platelet concentrates (PC) has not been investigated so far. Therefore, we performed a pilot study evaluating the predictive value of perioperative MEA measurements for PC transfusion in cardiac surgery.…”

Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study

“…The AUC reference ranges for the ASPI test (cyclooxygenase dependent aggregation using arachidonic acid sensitive to ASA and other inhibitors of platelet cyclooxygenase) and ADP test (ADP-induced platelet activation sensitive to clopidogrel and other ADP receptor antagonists) were 71-115 U and 57-113 U, respectively, in accordance with the manufacturer's recommendations. Based on the literature data, it was accepted that in patients who take ASA, an AUC of 30 U indicates aspirin sensitivity (ASA responders) 23) and an AUC of 40 U indicates aspirin resistance (ASA non-responders) 24) . In patients who take clopidogrel, an AUC of 31 U indicates clopidogrel sensitivity (clopidogrel responders) 25) and an AUC of 46 U indicates clopidogrel resistance (clopidogrel non-responders) 26) .…”