Control of an outbreak of group C meningococcal meningitis with a polysaccharide vaccine

Masterton, R G; Youngs, E R; Wardle, Jane; Croft, K.F.; Jones, D. M.

doi:10.1016/s0163-4453(88)91907-x

Cited by 23 publications

(13 citation statements)

References 8 publications

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“…These unconjugated polysaccharide vaccines confer protection to persons older than 2 years even when they are complement deficient (411). Vaccination has been highly effective in the control of community outbreaks and epidemics in military centers (285,304,396). Similarly, these polysaccharide vaccines are able to control large epidemics in African countries in the meningitis belt, provided that surveillance is adequate and the vaccination is started before the epidemic threshold is passed (505).…”

Section: Primary Preventionmentioning

confidence: 99%

“…Similarly, these polysaccharide vaccines are able to control large epidemics in African countries in the meningitis belt, provided that surveillance is adequate and the vaccination is started before the epidemic threshold is passed (505). Vaccination does not reduce the transfer of bacteria to nonvaccinated persons, and carrier status is unaffected (304,316).…”

Section: Primary Preventionmentioning

confidence: 99%

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Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

Deuren¹,

Brandtzæg²,

Meer³

2000

Clinical Microbiology Reviews

398

236

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Section: Primary Preventionmentioning

confidence: 99%

Section: Primary Preventionmentioning

confidence: 99%

Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

Deuren¹,

Brandtzæg²,

Meer³

2000

Clinical Microbiology Reviews

398

236

View full text Add to dashboard Cite

“…The effectiveness of chemoprophylaxis in outbreak control has been questioned in previous meningococcal disease outbreaks in Canada and the United Kingdom (9,10). One problem with chemoprophylaxis is that it is effective for a limited period of time.…”

Section: Discussionmentioning

confidence: 99%

“…However, the available evidence does not always indicate who else should receive chemoprophylaxis (6,18,21–28). Twenty-five percent of those who received chemoprophylaxis in this outbreak were not close contacts according to the ACIP definition (7); however, chemoprophylaxis, especially in highly publicized cases, is often given to people who do not fit the definition of a close contact (9,18,19). …”

Section: Discussionmentioning

confidence: 99%

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Mass Vaccination Campaign Following Community Outbreak of Meningococcal Disease

Krause

Blackmore

Wiersma

et al. 2002

Emerg. Infect. Dis.

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During December 12–29, 1998, seven patients ages 2–18 years were diagnosed with serogroup C meningococcal disease in two neighboring Florida towns with 33,000 residents. We evaluated a mass vaccination campaign implemented to control the outbreak. We maintained vaccination logs and recorded the resources used in the campaign that targeted 2- to 22-year-old residents of the two towns. A total of 13,148 persons received the vaccinations in 3 days. Vaccination coverage in the target population was estimated to be 86% to 99%. Five additional cases of serogroup C meningococcal disease occurred in the community during the year after the campaign began, four in patients who had not received the vaccine. The cost of control efforts was approximately $370,000. Although cases continued to occur, the vaccination campaign appeared to control the outbreak. Rapid implementation, a targeted approach, and high coverage were important to the campaign's success.

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