Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution

Jensen, Jørgen Steen; Jensen, Elsebeth Tvenstrup; Larsen, Anders Rhod; Meyer, Mechthild; Junker, L.; Rønne, T; Skov, Robert; Jepsen, Otto; Andersen, LP

doi:10.1016/j.jhin.2005.10.016

Cited by 22 publications

(18 citation statements)

References 39 publications

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“…CA-MRSA infections have been demonstrated to be more common in children, especially children less than 2 years of age (12). Outbreaks of MRSA have been noted in CCCs (18), and CCC attendance has been identified as a risk factor for CA-MRSA infections in the United States (9). Only limited information is available regarding the prevalence of colonization of healthy children attending CCCs in the United States.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factor Analysis for Methicillin-Resistant Staphylococcus aureus Nasal Colonization in Children Attending Child Care Centers

et al. 2011

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Children attending child care centers (CCCs) are at increased risk for infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). Nasal colonization often precedes infection, and MRSA colonization has been associated with increased infection risk. Community-associated MRSA (CA-MRSA) has caused increased MRSA infections in the general population, including children. Little is known about the frequency of MRSA nasal colonization in young children, particularly in those attending CCCs where disease transmission is common. We sampled the nares of 1,163 children in 200 classrooms from 24 CCCs in North Carolina and Virginia to assess S. aureus colonization. MRSA strains were molecularly analyzed for staphylococcal cassette chromosome mec (SCCmec) type, Panton-Valentine leukocidin status, and multilocus sequence type. A case-control study was performed to identify risk factors for MRSA colonization. We found that 18.1% children were colonized with S. aureus and 1.3% with MRSA. Molecular analysis of the MRSA strains identified 47% as CA-MRSA and 53% as health care-associated MRSA (HA-MRSA). Although two centers had multiple children colonized with MRSA, genotyping indicated that no transmission had occurred within classrooms. The case-control study did not detect statistically significant risk factors for MRSA colonization. However, MRSA-colonized children were more likely to be nonwhite and to have increased exposure to antibiotics and skin infections in the home. Both CA-MRSA and HA-MRSA strains were found colonizing the nares of children attending CCCs. The low frequency of colonization observed highlights the need for a large multicenter study to determine risk factors for MRSA colonization and subsequent infection in this highly susceptible population.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factor Analysis for Methicillin-Resistant Staphylococcus aureus Nasal Colonization in Children Attending Child Care Centers

et al. 2011

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“…In a low-prevalence country such as Denmark, a rigorously applied community 'search and destroy' policy may be successful in eradicating outbreaks initiated by the importation or emergence of the organism in defined populations of inhabitants. Both community and day-care institution interventions have been described [34,79]. Successful decolonisation in North Jutland, Denmark, was recently presented at the International Conference on Prevention & Infection Control (ICPIC) meeting [80].…”

Section: Decolonisationmentioning

confidence: 99%

Update on the prevention and control of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA)

Skov¹,

Christiansen²,

Dancer³

et al. 2012

International Journal of Antimicrobial Agents

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“…Nasal irrigation with mupirocin has been used in conjunction with infection control measures to successfully control an MRSA outbreak in an institution for the handicapped. 57 Although intranasal mupirocin is effective in eradicating colonisation, it is only marginally successful in eliminating MRSA colonisation of multiple body sites. 58,59 One major shortcoming of mupirocin is a growing, worldwide resistance.…”

Section: Discussionmentioning

confidence: 99%

Role of methicillin-resistant Staphylococcus aureus in head and neck infections

Brook

2009

J. Laryngol. Otol.

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The prevalence of infection with methicillin-resistant Staphylococcus aureus is increasing. Methicillin-resistant Staphylococcus aureus is also being recognised as an important pathogen in head and neck infections. This review summarises studies published over the past two decades which illustrate the growing prevalence of methicillin-resistant Staphylococcus aureus, and the current therapeutic approaches to head and neck infections caused by this bacterium. These infections include sinusitis, otitis, periorbital cellulitis, cervical lymphadenitis, tonsillitis, thyroiditis, retropharyngeal abscess, and abscesses and wounds of the neck. Treatment of head and neck infections associated with methicillin-resistant Staphylococcus aureus includes drainage and debridement, as well as administration of local and systemic antimicrobials that provide coverage against these organisms and against potential aerobic and anaerobic pathogens that may be present if the infection is polymicrobial.

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Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution

Cited by 22 publications

References 39 publications

Prevalence and Risk Factor Analysis for Methicillin-Resistant Staphylococcus aureus Nasal Colonization in Children Attending Child Care Centers

Prevalence and Risk Factor Analysis for Methicillin-Resistant Staphylococcus aureus Nasal Colonization in Children Attending Child Care Centers

Update on the prevention and control of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA)

Role of methicillin-resistant Staphylococcus aureus in head and neck infections

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