Control by Irradiation Alone of Nonfixed Clinically Positive Lymph Nodes From Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Supraglottic Larynx, and Hypopharynx

Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high‐dose clinical target volume in intensity‐modulated radiotherapy plan of nasopharyngeal carcinoma

“…The optimal dose required to control subclinical involvement remains unclear. Previous studies suggest that subclinical involvement should receive doses of 60–65 Gy administered in 6–7 weeks for epithelial tumors 23,33,34 . The present study showed that the 5 mm subclinical involvement in the China treatment plan for NPC received a dose of approximately 65 Gy (D95 = 66.06 ± 0.74, D98 = 64.05 ± 1.28 Gy; Figure 1C).…”

“…Previous studies suggest that subclinical involvement should receive doses of 60-65 Gy administered in 6-7 weeks for epithelial tumors. 23,33,34 The present study showed that the 5 mm subclinical involvement in the China treatment plan for NPC received a dose of approximately 65 Gy (D95 = 66.06 ± 0.74, D98 = 64.05 ± 1.28 Gy; Figure 1C). Previous studies reported that the 3-5-year local control for the Chinese NPC protocol is more than 95%.…”

Markers of neck failure in oral cavity and oropharyngeal carcinomas treated with radiotherapy

“…In the literature, neck control for N0 is greater than 95% , and it is 90% for N1, 78% for N2, and 70% for N3. [11][12][13][14] Besides nodal size, other factors determine the response to radiotherapy. Node fixation, T stage, and radiation doses are associated with neck control.…”

Tratamiento y profilaxis de las metástasis ganglionares de los carcinomas de cavidad oral

“…10 estiman que 5.000 cGys (rads) sólo controlan un 50 % de las adenopatías menores de 3 cm, elevándose esta cifra a un 90 % en caso de administrar 6.500 cGys (rads). Si la adenopatía es mayor de 3 cm o está fija, las posibilidades de fracaso son importantes, aún con 8.000 cGys (rads) 14 • Por estas razones, se obtiene una significativa mejora de los resultados, al asociar la irradiación y la cirugía en el manejo de las adenopatías cervi-cales 14 • 18 • En este sentido, la actitud que mantenemos es la realización de una irradiación terapéutica de las áreas ganglionares afectas, unida a una irradiación profiláctica del resto del cuello, seguida de una disección. En el caso de contraindicación sistémica o irresecabilidad local, se realiza una irradiación intersticial con Ir-192.…”