Markers of neck failure in oral cavity and oropharyngeal carcinomas treated with radiotherapy

Fortin, A.; Raybaud‐Diogène, Hèléne; Têtu, Bernard; Huot, Jacques; Blondeau, Lucie; Landry, Jacques

doi:10.1002/1097-0347(200102)23:2<87::aid-hed1003>3.0.co;2-u

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…The dysregulation of Hsp27 has also been suggested to contribute to invasion and metastasis [33]. More importantly, Hsp27 expression is associated with resistance to cytostatic anticancer drugs (e.g., cisplatin, vincristine and colchicine) and radiation therapy [34-37]. It is striking that Hsp27 is associated with poor prognosis in several tumor types (gastric [12,13], liver [14] and prostate carcinoma [15]), but good prognosis in others (endometrial adenocarcinomas [16,17] and oesophageal cancer [18,19]).…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma

et al. 2009

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BackgroundRecent proteomic studies identified Hsp27 as a highly over-expressed protein in oral squamous cell carcinoma (OSCC). Clinical studies that attempted to evaluate the prognostic values of Hsp27 yielded inconsistent results, which may be due to inclusion of OSCC cases from multiple anatomic sites. In this study, to determine the utility of Hsp27 for prognosis, we focused on oral tongue SCC (OTSCC), one of the most aggressive forms of OSCC.MethodsArchival clinical samples of 15 normal oral tongue mucosa, 31 dysplastic lesions, 80 primary OTSCC, and 32 lymph node metastases were examined for Hsp27 expression by immunohistochemistry (IHC). Statistical analyses were carried out to assess the prognostic value of Hsp27 expression for patients with this disease.ResultsDysregulation of Hsp27 expression was observed in dysplastic lesions, primary OTSCC, and lymph node metastases, and appears to be associated with disease progression. Statistical analysis revealed that the reduced Hsp27 expression in primary tumor tissue was associated with poor differentiation. Furthermore, the higher expression of Hsp27 was correlated with better overall survival.ConclusionOur study confirmed that the dysregulation of Hsp27 expression is a frequent event during the progression of OTSCC. The expression of Hsp27 appears to be an independent prognostic marker for patients with this disease.

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Section: Discussionmentioning

confidence: 99%

Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma

et al. 2009

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“…In head and neck cancer 25 and in breast cancer, 26 HSP27 was not found to predict survival but HSP27 predicted neck cancer failure after radiation therapy. 27 A few studies investigated the role of HSPs in ovarian cancer. HSP27 was not found to predict response to chemotherapy 5 but HSP Figure 1 Distribution of patients according to their response to chemotherapy and evolution.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas

et al. 2008

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Using the DNA microarray technology, we have identified genes that are differentially expressed in chemosensitive and chemoresistant ovarian serous papillary carcinomas and could potentially distinguish ovarian cancer patients based on their response to chemotherapy. The present study aims to evaluate the clinical usefulness of overexpression of selected genes by immunohistochemistry. Our cohort included 158 women who were operated on and received chemotherapy for an advanced serous papillary ovarian carcinoma (FIGO stages III and IV). The end point used in this study was progression-free survival. Immunohistochemistry was performed on microarray blocks containing all 158 cases. Twelve commercially available antibodies were selected. Of them, 10 corresponded to differentially expressed genes in our micro-array study and p53 and Ki67 were included. Antibodies were obtained for the following selected genes: GSTA1, MMP1, FOSB, CTSL2, HSP10, CD36, CXCL2, RBBP7, Siva, and PTGDS. Cox proportional hazards models, adjusted for standard risk factors, were used to estimate the associations between the markers and progression-free survival. No association was found between mRNA level and protein expression by immunohistochemistry. In multivariate analyses, patients whose tumors overexpressed HSP10 had a lower risk of progression than those with low expression (HR: 0.6; CI: 0.42-0.87; P ¼ 0.007). High level of proliferation (Ki67) tended to be associated with a lower risk of progression (HR: 0.72; CI: 0.51-1.03; P ¼ 0.07) whereas MMP1 overexpression tended to be associated with a higher risk of progression (HR: 1.61; CI: 0.94-2.79; P ¼ 0.08). Our study shows that gene expression analysis coupled with immunohistochemistry allowed the identification of HSP10 as an independent factor of progression-free survival. Modern Pathology (2008Pathology ( ) 21, 1002Pathology ( -1010 doi:10.1038/modpathol.2008 published online 23 May 2008 Keywords: serous ovarian carcinoma; chemoresistance; HSP10; DNA microarray; immunohistochemistry Ovarian cancer is responsible for more cancer deaths among women in the Western world than any other gynecologic malignancy. 1 An initial surgical approach is essential for aggressive cytoreduction and proper staging of the disease, since minimal residual tumor after surgery is a major factor of better response to chemotherapy and survival. 2 Intravenous combinated chemotherapy with taxol plus carboplatin is the current regimen of choice for the treatment of advanced ovarian cancer and is followed by a 50% complete pathologic remission rate. 3 Resistance to chemotherapy is, however, a major concern. Indeed, although significant proportions of women respond to chemotherapy, the majority of responders (approximately 60-75%) eventually relapses and dies from recurrent disease while 20-30% of patients never experience a clinical remission. 4 Chemotherapy resistance in ovarian

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“…Frequently, the data on oropharyngeal and oral cavity SCCA are combined to achieve a sufficient number of cases to reach valid conclusions. In addition, the boundaries of the oropharynx are arbitrarily defined and do not represent anatomical barriers to the extension of malignant disease; therefore, these cases are often incorporated into studies that involve the oral cavity, the larynx, the nasopharynx, and the hypopharynx 1–4 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, the boundaries of the oropharynx are arbitrarily defined and do not represent anatomical barriers to the extension of malignant disease; therefore, these cases are often incorporated into studies that involve the oral cavity, the larynx, the nasopharynx, and the hypopharynx. [1][2][3][4] According to the sixth edition of the staging manual of the American Joint Committee on Cancer (AJCC), 5 "the oropharynx is the portion of the continuity of the pharynx extending from the plane of the superior surface of the soft palate, to the superior surface of the hyoid bone [or floor of the vallecula]. It includes the base of the tongue, the inferior [anterior] surface of the soft palate and the uvula, the anterior and posterior tonsillar pillars, the glossotonsillar sulci, the pharyngeal tonsils, and the lateral and posterior pharyngeal walls."…”

Section: Introductionmentioning

confidence: 99%

Carcinoma of the Oropharynx: Factors Affecting Outcome

Sundaram¹,

Schwartz²,

Har‐El³

et al. 2005

The Laryngoscope

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Markers of neck failure in oral cavity and oropharyngeal carcinomas treated with radiotherapy

Cited by 15 publications

References 28 publications

Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma

Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma

Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas

Carcinoma of the Oropharynx: Factors Affecting Outcome

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