Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders

Lucerne, Kelsey E.; Osman, Aya; Meckel, Katherine; Kiraly, Drew D.

doi:10.1016/j.neuropharm.2021.108598

Cited by 23 publications

(9 citation statements)

References 207 publications

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“…One such study identified a relationship between gut bacterial content and behavioral features of impulsivity and attention ( Peterson et al, 2020 ). Thus, individualized peripheral systems such as the microbiome can impinge on central brain systems, including DA circuits, in ways that could produce unique SUD vulnerabilities ( Lucerne et al, 2021 ).…”

Section: Other Considerations For Animal Models Of Substance Use Disordermentioning

confidence: 99%

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Poisson

Engel

Saunders

2021

Front. Neural Circuits

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Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction is formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated substance use, social or lifestyle impairment, and risky substance use. Considerable efforts have been made to model features of these criteria in non-human animal research subjects, for insight into the underlying neurobiological mechanisms. Here we review evidence from rodent models of SUD-inspired criteria, focusing on the role of the striatal dopamine system. We identify distinct mesostriatal and nigrostriatal dopamine circuit functions in behavioral outcomes that are relevant to addictions and SUDs. This work suggests that striatal dopamine is essential for not only positive symptom features of SUDs, such as elevated intake and craving, but also for impairments in decision making that underlie compulsive behavior, reduced sociality, and risk taking. Understanding the functional heterogeneity of the dopamine system and related networks can offer insight into this complex symptomatology and may lead to more targeted treatments.

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Section: Other Considerations For Animal Models Of Substance Use Disordermentioning

confidence: 99%

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Poisson

Engel

Saunders

2021

Front. Neural Circuits

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“…The frequent use of addictive drugs intensifies their influence on GM, which will have lasting effects on users’ psychological and physiological functions. In addition, the gut sends signals to the brain through the production of neuroactive metabolites, signaling via the vagus nerve, and interactions with the immune system ( 56 , 57 ). This is a new way to understand the relationship between the GM and DUDs.…”

Section: Gut Microbiota and Drug Takingmentioning

confidence: 99%

Potential roles of the gut microbiota in the manifestations of drug use disorders

et al. 2022

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Drug use disorders (DUDs) not only cause serious harm to users but also cause huge economic, security, and public health burdens to families and society. Recently, several studies have shown that gut microbiota (GM) can affect the central nervous system and brain functions. In this review, we focus on the potential role of the GM in the different stages of DUDs. First, the GM may induce individuals to seek novel substances. Second, the gut microbiota is involved in the decomposition and absorption of drugs. Symptoms of individuals who suffer from DUDs are also related to intestinal microorganisms. Third, the effects of the GM and its metabolites on drug relapse are mainly reflected in the reward effect and drug memory. In conclusion, recent studies have preliminarily explored the relationship between GM and DUDs. This review deepens our understanding of the mechanisms of DUDs and provides important information for the future development of clinical treatment for DUDs.

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“…The microbiome can impact virtually any addiction where the microbiota can: (1) metabolize the addictive food, drug or chemical, or (2) affect the brain chemistry connected to the behavior. Lucern et al [ 136 ] recently examined the contributions of the gut microbiome–peripheral immune–central nervous system interactions in determining precisely who is likely to develop SUD.…”

Section: Who Behavior Modifications #2 and #3: Consume Less Alcohol And Stop Using Tobacco (In Spite Of The Microbiome’s Role In Addictiomentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

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Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders

Cited by 23 publications

References 207 publications

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Potential roles of the gut microbiota in the manifestations of drug use disorders

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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