Contribution to the Evaluation of Antibacterial Activity of Allium Sativum L. (Garlic) Essential Oil and Fresh Juice

Chekroud, Zohra; Silini, Hanene; Khalf, Sara; Redjem, Youcef

doi:10.20469/ijaps.5.50002-2

Cited by 2 publications

(1 citation statement)

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“…Based on the most frequent definition of multi-drug resistance proposed by Magiorakos et al 48 for Gram-positive and Gram-negative bacteria are "resistant to three or more classes of antimicrobials", all strains used in this study were considered multi-resistant, namely: Aerococcus viridans; Staphylococcus epidermidis and Staphylococcus xylosus. Several studies report a higher activity of Allium sativum L. essential oils against Staphylococcus aureus with a ranging inhibition diameter from 18 to 20mm 29,49 . Nevertheless, the study conducted by Zouari Chekki et al 50 reports a low activity of Allium sativum L. essential oils against Staphylococcus aureus (12 mm).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Chemical Composition and Biological Activity of Allium Sativum L. Essential Oil Against MDR Bacteria Isolated From Buccal Cavity Affected by Caries

Imane,

Selles,

Hocine

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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Natural remedies have proven to be very effective and have fewer side effects than commercial antibiotics. The objectives of this work were to determine the chemical compounds and biological (antibacterial and antioxidant) activities of Allium sativum L. essential oil against three multi-drug strains of bacteria isolated from buccal cavity affected by caries namely Aerococcus viridans, Staphylococcus epidermidis, and S. xylosus. The essential oil was extracted by hydrodistillation, chemical compounds were quantified by gas chromatography-mass spectrometry and gas chromatography with flame ionization detection. 2,2-diphenyl-1picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing power were used to study antioxidant activity. Antibacterial activity was carried out by the disk diffusion method. The average yield of the essential oil was 0.173±0.009% (w/w). All tested strains were resistant to three different classes of antibiotics. Diallyl disulfide (39.22%) and diallyl trisulfide (34.85%) were the main components of Allium sativum L. essential oils. DPPH radical scavenging assay showed the median inhibitory concentration (IC50) value of 51.12±11.77 mg/ml, while the ferric reducing power assay recorded the median effective concentration (EC50) value of 6.54 ± 0.63 mg/ml. The results showed that all multidrug-resistant bacteria strains tested are sensitive to essential oils. The results indicate that Allium sativum L. essential oil exercises good in-vitro antibacterial and weak to moderate in-vitro antioxidant activities.

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