Contribution to the coincidence of malignant tumours and some allergic manifestations.

Abstract

95The OBJECTIVE of this presentation has been to summarize some preliminary results concerning malignancies of patients with regard to their medical history of allergic manifestations (ALL).The SAMPLE: Patients followed at St. Mary's Hospital (SMH). The study consisted of adult patients (15 years and over) admitted at SMH with all kinds of diagnoses. During the 32 year period , a total of 470,462 patients have been admitted at SMH, which represents a yearly admittance average of 14,702 patients. Our sample concerned the subtotal of 12,206 patients with malignant tumors, admitted at SMH during the 32 year period (yearly average of 381 patients), with or without a history of ALL. Patients followed at SMH in several out-patient clinics as well as those treated at home under SMH supervision, or in other SMH-connected facilities have been excluded from this survey. Repeated admissions of the same patient with malignant tumor have been considered as separate cases. From the subtotal of 12,206 admitted malignancies, 366 have been identified with both tumors and ALL, which represents 3.0% during the 32 year period . The remaining 11,840 patients with tumors but no recorded ALL amounted thus to 97.0% of the hospital admitted malignancies. The latest decimal WHO-classification of diseases has been used for diagnosing of both tumors and ALL. 4 For the exhaustive summarization see Table 1.From our target population of 366 patients with both tumors and ALL, we have been able to study in more details the earlier period than the more recent one (1990)(1991)(1992)(1993)(1994)(1995)(1996). The 366 patients represent an incidence of 11.4 cases per year. Calculations of chi-square as well as the expected and observed frequencies have been performed. The shortcomings and biases of our approach have been taken into consideration. 5 The respective chi-square testing is equivalent with the comparison of the relative frequencies of the occurrence of ALL in tumorous and non-tumorous groups.Some RESULTS from the first period : there were 187 patients with both tumors and ALL (51.1% from the total of 366 patients . The sex distribution among them was quite uniform: 49.2% of men and 50.8% of women. The average age amounted to 66.4 years; it was higher among men (68.3 years) than among women (64.5 years). The distribution of age groups formed a typical bell-shaped curve, with a peak in the 60-69 age group. Smoking was not a determinant; this information was available among 72.7% of patients. Neither was the type of occupation a discriminating factor. Patients with a history of ALL concerned the following categories of tumors (in decreasing order): malignancies of the digestive system (26%), urogenital tumors (16%), respiratory tumors (13%), gynecologic tumors, breast cancers, malignant hemopathies (about 10% in each category) and about 15% of other malignancies. 3 Some COMMENTS for the total 32 year period :The observed value of 366 patients admitted at SMH with a confirmed malignancy, having had a recorded history of ALL, is relatively lo...

A systematic review of the safety of topical therapies for atopic dermatitis

“…An additional seven publications were reviewed based on a review of the reference sections of those publications that were fully reviewed. As a result, 45 publications were evaluated more fully 101–144 …”

Monoclonal gammopathies and malignancies in patients with chronic urticaria

“…A number of patients presenting with CU at an older age have an underlying monoclonal gammopathy of undetermined significance (MGUS) or malignancy. Studies of atopic patients suggest a higher frequency of malignancy compared with the general population 12–14 . Furthermore, individuals with urticaria were more likely to develop a hematologic malignancy 14 …”